A continuous flow process for biaryls based on sequential Suzuki–Miyaura coupling and supercritical carbon dioxide extraction

Abstract

We report a continuous flow process for biaryls consisting of a packed-bed reactor and a rapid extraction system. Continuous extraction with supercritical carbon dioxide (scCO2) was applied to a Suzuki–Miyaura...

Solvent selection based on a conceptual process design by combining cost evaluation and life cycle assessments for developing new reaction pathways

“…The Suzuki-Miyaura coupling is one of the most useful synthetic routes to form carbon-carbon and carbon-heteroatom bonds, [28][29][30] in which solvent mixtures are commonly used for the reaction. An organic solvent, such as ether, or an amide, is often used, and water is often a common cosolvent since both the reactant and the carbonates need to be dissolved.…”