A construction of novel iron-foam-based calcium phosphate/chitosan coating biodegradable scaffold material

Wen, Zhixun; Zhang, Liming; Chen, Chao; Liu, Yibo; Wu, Changjun; Dai, Changsong

doi:10.1016/j.msec.2012.10.009

Cited by 42 publications

(36 citation statements)

References 45 publications

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“…Different biocompatible porous metals have been studied to serve as scaffolds for orthopedic applications: tantalum, magnesium and its alloys, titanium and its alloys, and iron-foam based materials [5,6]. Magnesium, iron and zinc are considered as biodegradable metals.…”

Section: Introductionmentioning

confidence: 99%

“…However, a major challenge of using iron as a biodegradable implant is its slow rate of degradation [7,14]. Different approaches have been proposed to improve the corrosion rate of iron such as alloying elements modification, poly(lactic-co-glycolic acid) infiltration, and coating [6,[15][16][17]. The objective of this study is to investigate the mechanical behavior of iron-foams as a function of their structural geometry where several iron foam specimens with different structural properties underwent uniaxial compression tests.…”

Section: Introductionmentioning

confidence: 99%

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Investigation on Mechanical Behavior of Biodegradable Iron Foams under Different Compression Test Conditions

Alavi

Trenggono

Champagne

et al. 2017

Metals

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Biodegradable metal foams have been studied as potential materials for bone scaffolds. Their mechanical properties largely depend on the relative density and micro-structural geometry. In this work, mechanical behavior of iron foams with different cell sizes was investigated under various compression tests in dry and wet conditions and after subjected to degradation in Hanks' solution. Statistical analysis was performed using hypothesis and non-parametric tests. The deformation behavior of the foams under compression was also evaluated. Results show that the mechanical properties of the foams under dry compression tests had a "V-type" variation, which is explained as a function of different geometrical properties by using a simple tabular method. The wet environment did not change the compression behavior of the iron foams significantly while degradation decreased the elastic modulus, yield and compression strengths and the energy absorbability of the specimens. The deformation of open cell iron foams under compression is viewed as a complex phenomenon which could be the product of multiple mechanism such as bending, buckling and torsion.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Investigation on Mechanical Behavior of Biodegradable Iron Foams under Different Compression Test Conditions

Alavi

Trenggono

Champagne

et al. 2017

Metals

View full text Add to dashboard Cite

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“…Coating of bioceramics to biodegradable metals or developing composites of both materials are two envisioned directions. A CaP/chitosan composite was coated on porous Fe via electrophoretic deposition as a promising new way to control degradation and bioactivity but further process optimization was needed . Other work has coated pure‐Fe with CaZn 2 (PO 4 ) 2 ·2H 2 O via chemical reaction method and was found to improve antihemolysis property and cell compatibility .…”

Section: Introductionmentioning

confidence: 99%

Evidences ofin vivobioactivity of Fe‐bioceramic composites for temporary bone implants

et al. 2014

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Iron-bioceramic composites have been developed as biodegradable implant materials with tailored degradation behavior and bioactive features. In the current work, in vivo bioactivity of the composites was comprehensively studied by using sheep animal model. Five groups of specimens (Fe-HA, Fe-TCP, Fe-BCP composites, and pure-Fe and SS316L as controls) were surgically implanted into medio proximal region of the radial bones. Real-time ultrasound analysis showed a decreased echo pattern at the peri-implant biodegradation site of the composites indicating minimal tissue response during the wound healing process. Peripheral whole blood biomarkers monitoring showed a normal dynamic change of blood cellular responses and no stress effect was observed. Meanwhile, the released Fe ion concentration was increasing along the implantation period. Histological analysis showed that the composites corresponded with a lower inflammatory giant cell count than that of SS316L. Analysis of the retrieved implants showed a thicker degradation layer on the composites compared with pure-Fe. It can be concluded that the iron-bioceramic composites are bioactive and induce a preferable wound healing process.

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“…After measuring the area of the foams using a digital micrometer (IP65, Mitutoyo Co., Ltd, Kanagawa, Japan), each specimen was crashed vertically with a load cell at a crosshead speed of 1 mm/min [6,8,[17][18][19][20][21] using a table-mount universal testing machine (Autograph AGS-J, Shimadzu Corp., Kyoto, Japan). For each group, 8 specimens were tested to determine the average compressive strength value.…”

Section: Characterizationmentioning

confidence: 99%

Effects of PLGA reinforcement methods on the mechanical property of carbonate apatite foam

Munar

Tsuru

et al. 2014

Bio-Medical Materials and Engineering

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The purpose of this study was to improve the mechanical property of brittle carbonate apatite (CO 3 Ap) foam aimed as bone substitute material by reinforcement with poly(DL-lactide-co-glycolide) (PLGA). The CO 3 Ap foam was reinforced with PLGA by immersion and vacuum infiltration methods. Compressive strength of CO 3 Ap foam (12.0 ± 4.9 kPa) increased after PLGA reinforcement by immersion (187.6 ± 57.6 kPa) or vacuum infiltration (407.0 ± 111.4 kPa). Scanning electron microscopic (SEM) observation showed a gapless PLGA and CO 3 Ap foam interface and larger amount of PLGA inside the hollow space of the strut when vacuum infiltration method was employed. In contrast a gap was observed at the PLGA and CO 3 Ap foam interface and less amount of PLGA inside the hollow space of the strut when immersion method was employed. Strong PLGA-CO 3 Ap foam interface and larger amount of PLGA inside the hollow space of the strut is therefore the key to higher mechanical property obtained for CO 3 Ap foam when vacuum infiltration was employed for PLGA reinforcement.

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A construction of novel iron-foam-based calcium phosphate/chitosan coating biodegradable scaffold material

Cited by 42 publications

References 45 publications

Investigation on Mechanical Behavior of Biodegradable Iron Foams under Different Compression Test Conditions

Investigation on Mechanical Behavior of Biodegradable Iron Foams under Different Compression Test Conditions

Evidences ofin vivobioactivity of Fe‐bioceramic composites for temporary bone implants

Effects of PLGA reinforcement methods on the mechanical property of carbonate apatite foam

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