A Concurrence of Adenocarcinoma with Micropapillary Features and Composite Glandular-Endocrine Cell Carcinoma in the Stomach

Kim, Ji Hoon; Eom, Dae-Woon; Park, Cheon Soo; Kwak, Jae Young; Park, Eun Hwa; Kwak, Jin Ho; Jang, Hyuk Jae; Choi, Kyu Sun; Han, Myung Sik

doi:10.5230/jgc.2016.16.4.266

Cited by 4 publications

(2 citation statements)

References 10 publications

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“…Because the majority of reports on GCA have been collected from patients with appendiceal origin, the data on GCA in the stomach is extremely scarce. To our knowledge, there have been just five cases (in four reports) describing GCA of the stomach in the English literature [ 3 - 6 ]. The summary of the reported cases, including ours, is shown in Table 1 .…”

Section: Discussionmentioning

confidence: 99%

Goblet Cell Adenocarcinoma in the Stomach: A Case Report

Enomoto,

Arai,

Meguro

et al. 2024

Cureus

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Goblet cell adenocarcinoma (GCA) is known as an amphicrine tumor often seen in the appendix. Here, we report a rare case of GCA in the stomach. An 80-year-old man underwent gastroscopy due to epigastric pain and was diagnosed with gastric cancer. He received total gastrectomy and histology showed a mixture of a moderately-differentiated tubular adenocarcinoma, a mucinous adenocarcinoma, and a tumor composed of goblet-like mucinous cells with neuroendocrine differentiation. The tumor volume ratio was about 4:1:5, respectively, and a final diagnosis of GCA was made. The metastasis of the regional lymph node was occupied by only the component of goblet-like cells. GCA should be recognized as a rare histologic subtype of gastric cancer.

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Section: Discussionmentioning

confidence: 99%

Goblet Cell Adenocarcinoma in the Stomach: A Case Report

Enomoto,

Arai,

Meguro

et al. 2024

Cureus

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“…However, few reports have described amphicrine differentiation in gastric cancer. 3-5 Therefore, the pathobiological and clinicopathological features of amphicrine gastric cancer remain unclear. Here, we report a case of amphicrine gastric cancer.…”

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confidence: 99%

A Case of Gastric Amphicrine Signet-Ring Cell Carcinoma

Yuki

Saigo

Asano³

et al. 2019

Clin Med�Insights�Pathol

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“Amphicrine” (in Greek, amphi- means “both” or “double”) refers to cells that synchronously exhibit the endocrine and exocrine phenotypes. Gastric amphicrine carcinoma is very rare, and only a few case reports are found in the English literature; thus, its pathobiological features remain unclear. Here, we report a case of amphicrine gastric carcinoma. A woman in her sixth decade of life presented with anemia and underwent upper endoscopy, followed by histopathological examination of biopsy specimens. She appeared to have gastric cancer with a tumor measuring 5.0 cm × 4.0 cm in size. Subsequently, the patient underwent total gastrectomy with lymph node dissection. Histopathological examination revealed a poorly cohesive carcinoma that sparsely coexisted with signet-ring cell carcinoma cells with regional lymph node metastasis. Interestingly, synaptophysin immunoreactivity with the coexistence of Alcian blue was found in individual signet-ring cell carcinoma cells. Furthermore, the present amphicrine carcinoma cells immunohistochemically expressed CD44 variant 9, a functional cancer stem cell marker. We believe that the present case findings may support the idea of multipotent stem cells being an origin of amphicrine gastric cancers.

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Micropapillary early gastric carcinoma with distinct clinicopathological features, high risk for lymph node metastasis, and dismal prognosis: a multicenter clinicopathological study of 29 cases identified in 1890 early gastric carcinoma radical gastrectomies

Cheng

Wang

et al. 2019

Human Pathology

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A Concurrence of Adenocarcinoma with Micropapillary Features and Composite Glandular-Endocrine Cell Carcinoma in the Stomach

Cited by 4 publications

References 10 publications

Goblet Cell Adenocarcinoma in the Stomach: A Case Report

Goblet Cell Adenocarcinoma in the Stomach: A Case Report

A Case of Gastric Amphicrine Signet-Ring Cell Carcinoma

Micropapillary early gastric carcinoma with distinct clinicopathological features, high risk for lymph node metastasis, and dismal prognosis: a multicenter clinicopathological study of 29 cases identified in 1890 early gastric carcinoma radical gastrectomies

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