A computer program to make linkage analysis with liped and linkage easier to perform and less prone to input errors

Phenotype of a British North Carolina macular dystrophy family linked to chromosome 6q

“…Genotyping was performed with six microsatellite marker loci as described previously 4. Data were collected using linksys 3.1,34 and two point linkage analysis was performed using the mlink subprogram of the linkage package 5.10 35. Allele frequencies were calculated from the five spouses in the family.…”

Three keratin gene mutations account for the majority of dominant simplex epidermolysis bullosa cases within the population of Ireland

“…Linkage analysis was carried out using the LIPED program in conjunction with LODSCORE and the data management package LINKSYS, version 3.1 (Ott, 1974;Lathrop et al, 1984;Attwood and Bryant, 1988).…”

Genetic mapping of a cone and rod dysfunction (Aland Island eye disease) to the proximal short arm of the human X chromosome.

“…The family that we have studied has provided the opportunity to examine their visual function from infancy to late adulthood (2 to 49 years) which differs from the essentially adult age group available to Elenius et al2 and Rosenberg et al3 but is closely comparable to the age range studied in CSNB2.5 The records of previous ophthalmological assessments on IV 8 over some 20 years suggest that the condition shows progression throughout childhood until early adult life consistent with the retrospective information available to Rosenberg et al 3 It is possible that the decline in visual function seen in IV 8 could be attributed to the increasing myopia alone as the result of normal growth in the first two decades of life but this seems less likely since the myopia in AIED is unaccompanied by signs of myopic degeneration of the fundus. 23 The essentially stationary nature of the condition is consistent with AIED235 and CSNB2.' All our affected subjects have significant myopia (ranging from -30 D to -3 D) accompanied by astigmatism consistent with the findings in the original family.25 However, Rosenberg et al3 found one affected male with near normal refraction and suggested that an age dependent transition from hyperopia to myopia may occur.…”