A Computer-aided Study on the Tissue Changes in Oral Keratoses and Lichen Planus, and an Analysis of Case Groupings by Subjective and Objective Criteria

Kramer, I.R.H.; Lucas, R. B.; El‐Labban, N.G.; Lister, Leonard M.

doi:10.1038/bjc.1970.49

Cited by 74 publications

(46 citation statements)

References 10 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…The material used for the previous studies, and for part of the work described here, consisted of 235 consecutive biopsies of oral lesions on which the final clinicopathological diagnosis was leukoplakia, keratosis or lichen planus (the definitions of the first two of these terms were given in Kramer et al, 1970a). This was a retrospective survey, so that follow-up was available on almost all of the patients.…”

Section: Methods and Resultsmentioning

confidence: 99%

“…The definitions of the histological criteria were summarized previously (Kramer et al, 1970a). The observer was trained to record each feature independently, and without any attempt at interpretation.…”

Section: Methods and Resultsmentioning

confidence: 99%

“…Thus, a feature would be given a low value if it was consistently found in both diagnostic groups; if it is a typical feature of both groups, it is of little value in distinguishing between them. Kramer et al, 1970a) shows the separation of the original 60 cases of leukoplakia from the original 48 cases of lichen planus. As previously noted, all leukoplakias had scored below 300, and all lichen planus cases had scored above 300.…”

Section: Methods and Resultsmentioning

confidence: 99%

“…Various aspects of these computeraided studies have been reported (Kramer, 1969;Kramer et al, 1969Kramer et al, , 1970aKramer et al, , 1970b and it will be necessary to give here only a brief summary of the basic approach and methods.…”

mentioning

confidence: 99%

See 3 more Smart Citations

Further Studies on Lesions of the Oral Mucosa Using Computer-Aided Analyses of Histological Features

Kramer¹,

El‐Labban²,

Sonkodi³

1974

Br J Cancer

Self Cite

View full text Add to dashboard Cite

Summary-The histological feature of various "white lesions" of the oral mucosa have been subjected to computer-aided analyses, with the objectives of improving the accuracy of diagnosis, and the more reliable identification of the lesions most likely to progress to carcinoma.Previous reports on these studies have shown the potential usefulness of cluster and discriminant analyses, both for the classification of cpes into their diagnostic groups, and for the identification of the tissue changes most useful in discriminating between one disease and another.The present report describes two extensions of this work. The first was the application of a scoring technique, based on discriminant analysis, to a new series of cases. In this series, the computer " correctly " identified 36 out of 41 that had been diagnosed as lichen planus by conventional methods. The second part of the study involved the calculation of the importance of each histological variable in defining the characteristics of groups of cases placed into different diagnostic groups or clusters by the computer. From these calculations, it was possible to depict the histological characteristics of each group in diagrammatic form.

show abstract

Section: Methods and Resultsmentioning

confidence: 99%

Section: Methods and Resultsmentioning

confidence: 99%

Section: Methods and Resultsmentioning

confidence: 99%

mentioning

confidence: 99%

See 2 more Smart Citations

Further Studies on Lesions of the Oral Mucosa Using Computer-Aided Analyses of Histological Features

Kramer¹,

El‐Labban²,

Sonkodi³

1974

Br J Cancer

Self Cite

View full text Add to dashboard Cite

show abstract

“…Leukoplakia undergoes carcinomatous transformation in about 5 % of patients (Kramer et al, 1970), and it is the precancerous nature of some of these lesions that makes it an important condition for investigation. An immunopathological investigation of this disease revealed that saline homogenates of leukoplakic tissue induce slight stimulation of autologous lymphocytes (Lehner, 1970a (Lehner, 1971 .…”

mentioning

confidence: 99%

Cell-mediated Immunity and Antibodies to Herpesvirus hominis Type 1 in Oral Leukoplakia and Carcinoma

Lehner¹,

Wilton²,

Shillitoe³

et al. 1973

Br J Cancer

View full text Add to dashboard Cite

Summary.-Cell-mediated and humoral immune responses to Herpesvirus hominis type 1 (HVH1) and Candida albicans were studied in patients with leukoplakia, showing a histological spectrum of changes from epithelial keratosis to acanthosis and atypia, and in patients with carcinoma. The results were ranked according to increasing values of stimulation indices of lymphocyte transformation to HVH1, and the corresponding macrophage migration inhibition indices, and complement fixing antibody titres of each patient were correlated. This revealed that most patients with epithelial atypia were clustered to that end of the spectrum which had the highest stimulation and migration indices to HVH1; this relationship was not evident with C. albicans. In patients with keratosis and acanthosis there was a significant lack of correlation between lymphocyte transformation and migration inhibition to both HVH1 and C. albicans. In carcinoma the indices of lymphocyte transformation and migration inhibition to HVH1 and C. albicans were depressed. Furthermore, a significant negative correlation was found between lymphocyte transformation and migration inhibition to HVH1, unlike the positive correlation in control subjects. Complement fixing antibodies to HVH1, HVH2, cytomegalovirus and adenovirus, and fluorescent antibodies to C. albicans failed to show a significant change in titre in any one group of subjects tested. The results suggest a cellmediated immune defect in leukoplakia, with a dissociation between lymphocyte transformation and macrophage migration inhibition to HVH1 and C. albicans in cases of keratosis or acanthosis. A specific increase in cell-mediated immunity to HVH1 in leukoplakia with epithelial atypia and the sequential changes argue in favour of a possible participation of HVHl in carcinomatous transformation of some leukoplakias.

show abstract

How Important Is Tumour Shape? Quantification of the Epithelial-Connective Tissue Interface in Oral Lesions Using Local Connected Fractal Dimension Analysis

Landini

Rippin

1996

J. Pathol.

View full text Add to dashboard Cite

Quantification of the local complexity of the epithelial–connective tissue interface (ECTI) in normal mucosa, epithelial dysplasia, and squamous cell carcinoma of the floor of the mouth was investigated by estimating the local connected fractal dimension in tissue profiles from histological sections. The use of certain parameters of the distribution of the local connected fractal dimensions of the ECTI classifies the cases belonging to these three histopathological diagnoses with 85 per cent accuracy by means of linear discriminant analysis. The values of the local fractal dimension were also used to produce colour‐coded dimensional images of the ECTI, to highlight locations with higher irregularity that may correlate with locally invasive ‘higher‐risk’ areas.

show abstract

A Computer-aided Study on the Tissue Changes in Oral Keratoses and Lichen Planus, and an Analysis of Case Groupings by Subjective and Objective Criteria

Cited by 74 publications

References 10 publications

Further Studies on Lesions of the Oral Mucosa Using Computer-Aided Analyses of Histological Features

Further Studies on Lesions of the Oral Mucosa Using Computer-Aided Analyses of Histological Features

Cell-mediated Immunity and Antibodies to Herpesvirus hominis Type 1 in Oral Leukoplakia and Carcinoma

How Important Is Tumour Shape? Quantification of the Epithelial-Connective Tissue Interface in Oral Lesions Using Local Connected Fractal Dimension Analysis

Contact Info

Product

Resources

About