A Computational Study of Famciclovir Derivatives Against Thymidine
Kinase as a Molecular Target for the Development of Novel Anticancer
Drugs via Suicide Gene Therapy Concepts
Abstract:Background:
The viral thymidine kinase (TK) phosphorylates the antiviral medication famciclovir (FCV), which treats herpes simplex virus (HSV-TK). The phosphorylated FCV destroys the infected cells by preventing cellular DNA synthesis.
Objective:
We hypothesize that FCV impurity, which is a related substance to FCV, should be efficient in killing cells independent of HSV-TK and is currently the most widely used suicide agent for gene therapy of cancer.
Method:
This study proposes the binding affinity of th… Show more
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