A computational modelling study of transcranial direct current stimulation montages used in depression

Bai, Shuxiong; Dokos, Socrates; Ho, Kerrie-Anne; Loo, Colleen

doi:10.1016/j.neuroimage.2013.11.015

Cited by 143 publications

(125 citation statements)

References 65 publications

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“…For depression, DLPFC is a rational target and results seem promising. A computed modeling study suggests fronto-extracephalic or fronto-occipital montages may be more efficient to stimulate DLPFC than montages used in the majority of the current studies (Bai et al 2014), which needs further verifications. Besides, daily stimulation is probably preferable because one investigation suggested it can induce significantly greater cortical excitability than tDCS every other day .…”

Section: Conclusion and Recommendationsmentioning

confidence: 83%

“…Only 259 individuals in seven RCTs were evaluated in the meta-analysis; therefore it may be underpowered for statistical comparison in terms of methodological optimality, such as number of sessions, duration of one session, electrode placement, patient characteristics predicting good response, and so forth. In terms of electrode placement, a computational modeling study of tDCS for depression (Bai et al 2014) suggests montages with the anodal electrode on frontal areas and the cathodal on occipital or extracellular areas may result in greater stimulation of deep structures, including anterior cingulate cortex. These authors suggest tDCS may be effective for melancholic depression, which deserves evaluations with RCTs.…”

Section: Depressionmentioning

confidence: 99%

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Application of transcranial direct current stimulation to psychiatric disorders: trends and perspectives

Yokoi

Sumiyoshi

2015

Neuropsychiatr Electrophysiol

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Background: Growing attention is paid to transcranial direct current stimulation (tDCS) as a novel neuromodulation method in the treatment of psychiatric illnesses. In spite of its simple procedure, electrophysiological influence of tDCS is complex and not fully understood. Therefore, its procedure and clinical application is yet to be established. To address this issue, we reviewed and summarized reports currently available, and proposed future directions. Methods: We searched PubMed for the literature of tDCS, targeting depression, cognitive enhancement or schizophrenia, sham-controlled, and repeated stimulation sessions. Results: Among psychiatric conditions, depression is most associated with positive effects of tDCS, based on the recent systematic review, due to homogeneity in methodology adopted in randomized sham-controlled trials. For cognitive enhancement and/or treatment of schizophrenia, results are less consistent, and the methods are more heterogeneous. Conclusion: Large-scale well-designed trials are needed to more accurately evaluate the efficacy of tDCS. In this article, considerations of optimal stimulation conditions are also provided.

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Section: Conclusion and Recommendationsmentioning

confidence: 83%

Section: Depressionmentioning

confidence: 99%

Application of transcranial direct current stimulation to psychiatric disorders: trends and perspectives

Yokoi

Sumiyoshi

2015

Neuropsychiatr Electrophysiol

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“…Along the same lines, future studies in dementia should also account for the amount of brain atrophy in their analysis of performance [89]. Computational models of the charge density are being used and integrated in tDCS studies [82,90]. In addition, the use of neurostimulation, functional imaging, and connectivity analysis may also improve our ability to predict how subjects may benefit from this treatment [6•, 91].…”

Section: Discussionmentioning

confidence: 99%

Transcranial Direct Current Stimulation (tDCS): Modulation of Executive Function in Health and Disease

Sarkis

Kaur

Camprodon

2014

Curr Behav Neurosci Rep

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Transcranial direct current stimulation (tDCS) is a noninvasive method of neuromodulation used in human basic and clinical neuroscience. In this article we review its use in the cognitive neurosciences to study executive function, and current preliminary explorations of its therapeutic value as a cognitive enhancer for patients with compromised dysexecutive symptoms. We discuss published studies analyzing their methodology and results. A number of experiments describe improvement in experimental measures of inhibitory control, working memory, and verbal fluency with anodal stimulation over the dorsolateral prefrontal cortex. Positive findings are also described in different clinical populations. Despite the growing promise and interest in tDCS given its safety, simplicity, and low cost, findings are not always consistent across studies due to a host of variables we discuss (study design, stimulation parameters, neuroanatomy, genetics, etc.), highlighting the need for a better mechanistic understanding of the effects of tDCS.

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“…Direct current stimulation was applied by a pair of surface sponge rubber electrodes (25 cm 2 ) soaked in saline and was administered by a DC-stimulator (Neuroconn, Ilmenau, Germany). The decision on the size of the electrodes was informed by the study of Bai et al (2014) in which they found that the use of a smaller electrode at F3 increased the E-field at the left DLPFC. The DLPFC was stimulated by placing the anode electrode centered over F3 according to the 10-20 international system for electroencephalogram electrode placement.…”

Section: Transcranial Direct Current Stimulationmentioning

confidence: 99%

Combining tDCS and Working Memory Training to Down Regulate State Rumination: A Single-Session Double Blind Sham-Controlled Trial

et al. 2015

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Rumination has been associated with reduced working memory and dorsolateral prefrontal cortex activity. This study explored whether single session anodal transcranial direct current stimulation (tDCS) applied to the dorsolateral prefrontal cortex and/or working memory training can transiently ameliorate working memory and down regulate state rumination. Sixty-six participants were randomly allocated to three conditions: (1) control training ? tDCS, (2) working memory training ? sham tDCS and (3) working memory training ? tDCS. Before and after manipulation participants performed working memory tasks and state rumination was measured with self-report and heart rate variability. Participants who received real tDCS were significantly faster in switching between information in working memory than participants who received sham tDCS. No effects on self-reported state rumination were found. However, both groups receiving working memory training showed a higher increase in heart rate variability than the control training group, indicating more adaptive self-regulation.

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A computational modelling study of transcranial direct current stimulation montages used in depression

Cited by 143 publications

References 65 publications

Application of transcranial direct current stimulation to psychiatric disorders: trends and perspectives

Application of transcranial direct current stimulation to psychiatric disorders: trends and perspectives

Transcranial Direct Current Stimulation (tDCS): Modulation of Executive Function in Health and Disease

Combining tDCS and Working Memory Training to Down Regulate State Rumination: A Single-Session Double Blind Sham-Controlled Trial

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