Application of transcranial direct current stimulation to psychiatric disorders: trends and perspectives

Yokoi, Yuma; Sumiyoshi, Tomiki

doi:10.1186/s40810-015-0012-x

Cited by 12 publications

(10 citation statements)

References 65 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…), to evaluate the efficacy of tDCS in the augmentation of various ADs, as well as to find a way to optimize treatment outcomes in resistant patients. The promising step might be the application of the high-definition tDCS (HD-tDCS), using an array of small electrodes (as small as those for electroencephalogram), which has been investigated in the context of better spatial resolution, increasing the focality 39…”

Section: Discussionmentioning

confidence: 99%

<p>Transcranial Direct-Current Stimulation (tDCS) Versus Venlafaxine ER In The Treatment Of Depression: A Randomized, Double-Blind, Single-Center Study With Open-Label, Follow-Up</p>

Bares

Brunovský

Stopková

et al. 2019

NDT

View full text Add to dashboard Cite

ObjectiveTranscranial direct-current stimulation (tDCS), a relatively new neuromodulation approach, provides some evidence of an antidepressant effect. This randomized, 4-week, double-blind study with 8-week, open-label, follow-up compared the efficacy and tolerability of left anodal tDCS with venlafaxine ER (VNF) in the treatment of depression and prevention of early relapse.MethodsSubjects (n = 57) received tDCS (2 mA, 20 sessions, 30 mins) plus placebo (n = 29) or VNF plus sham tDCS (n = 28). Responders to both interventions entered the open-label follow-up. The primary outcome was score change in the Montgomery–Åsberg Depression Rating Scale (MADRS) at week 4 of the study. Secondary outcomes were response, remission, dropout rates and relapse rates within the follow-up.The mean change in the MADRS score from baseline to week for patients treated with tDCS was 7.69 (95% CI, 5.09–10.29) points and 9.64 (95% CI, 6.20–13.09) points for patients from the VNF group, a nonsignificant difference (1.95, 95% CI −2.25–6.16; t (55) = 0.93, p= 0.36, Cohen´s d = 0.24). There were no significant between-group differences in the MADRS scores from baseline to endpoint (intention-to-treat analysis). The response/remission rate for tDCS (24%/17%) and VNF (43%/32%) as well as the dropout rate (tDCS/VNF; 6/6) did not differ significantly between groups. In the follow-up, relapse (tDCS/VNF; 1/2) and dropout (tDCS/VNF; 2/3) rates were low and comparable. LimitationsA relatively small sample size and short duration of the antidepressant treatment; no placebo arm.ConclusionOverall, this study found a similar efficacy of tDCS and VNF in the acute treatment of depression and prevention of early relapse. The real clinical usefulness of tDCS and its optimal parameters in the treatment of depression should be further validated.

show abstract

Section: Discussionmentioning

confidence: 99%

<p>Transcranial Direct-Current Stimulation (tDCS) Versus Venlafaxine ER In The Treatment Of Depression: A Randomized, Double-Blind, Single-Center Study With Open-Label, Follow-Up</p>

Bares

Brunovský

Stopková

et al. 2019

NDT

View full text Add to dashboard Cite

show abstract

“…The dorsolateral prefrontal cortex (DLPFC) is reported to be related to these circuits, and shows functional changes of cognitive function in schizophrenia ( 13 , 14 ). Transcranial direct current stimulation (tDCS) is a feasible and safe method, using weak and direct electrical current to the brain through electrodes ( 15 , 16 ). tDCS changes cortical excitability, modulated by glutamatergic activity via actions on catecholamine, acetylcholine and serotonin receptors ( 17 – 19 ).…”

Section: Introductionmentioning

confidence: 99%

Possible Facilitative Effects of Repeated Anodal Transcranial Direct Current Stimulation on Functional Outcome 1 Month Later in Schizophrenia: An Open Trial

et al. 2017

Self Cite

View full text Add to dashboard Cite

Recent research on neuromodulation techniques, such as transcranial direct current stimulation (tDCS), for the treatment of schizophrenia has mainly focused on psychotic symptoms. We aimed to determine whether repetitive tDCS is efficacious in improving determinants of outcome, such as cognitive function, daily living skills, and depressive mood in patients with schizophrenia. Twenty-eight patients underwent tDCS (2 mA × 20 min) two times per day for 5 consecutive days. The anodal electrode was placed over the left dorsolateral prefrontal cortex while the cathodal electrode was placed over the right supraorbital region. One month after the last stimulation, there was a significant improvement on cognitive function, measured by the brief assessment of cognition in schizophrenia (d = 0.49). Significant effects were also shown on daily living skills (functional capacity), measured by the UCSD performance-based skills assessment-brief (d = 0.70). Depressive symptoms, measured by the Calgary depression rating scale, as well as psychotic symptoms measured by on the positive and negative syndrome scale positive and general psychopathology subscales also responded to the treatment (d = 0.38, d = 0.48, and d = 0.50, respectively). This is the first study to suggest that tDCS with the anodal electrode on the left prefrontal cortex improves functional capacity and depressive symptoms in patients with schizophrenia. These results may add to the concept that tDCS provides a strategy to enhance functional outcomes in patients with schizophrenia.Trial Registration, UMIN000015953.

show abstract

“…Despite these lines of obscurity, the reported ability of tDCS to ameliorate psychiatric conditions still encourages further investigations. 7 Moreover, tDCS has several advantages over other modalities of neuromodulations, such as transcranial magnetic stimulation and electroconvulsive therapy. Compared with the latter 2 methods, tDCS is simple, inexpensive, and portable, providing a strong potential to further clinical use.…”

Section: Introductionmentioning

confidence: 99%

Transcranial Direct Current Stimulation in Depression and Psychosis: A Systematic Review

2017

Self Cite

View full text Add to dashboard Cite

Transcranial direct current stimulation, one of the neuromodulation paradigms, is attracting interest as a novel method to treat various central nervous system disorders. It is safe, portable, and cost-effective, and has been applied experimentally for patients with various neuropsychiatric conditions. For the clinical importance and preliminary positive results, growing number of randomized controlled trials to patients with depression or schizophrenia are reported, followed by systematic reviews and meta-analyses. However, former research specifically focuses on depression or psychosis in psychiatric disorders. Therefore, we provide a systematic review of studies reporting the effectiveness of transcranial direct current stimulation in ameliorating these symptoms not limited to psychiatric patients or objective scales by examining double-blind sham-controlled trials.

show abstract

Application of transcranial direct current stimulation to psychiatric disorders: trends and perspectives

Cited by 12 publications

References 65 publications

<p>Transcranial Direct-Current Stimulation (tDCS) Versus Venlafaxine ER In The Treatment Of Depression: A Randomized, Double-Blind, Single-Center Study With Open-Label, Follow-Up</p>

<p>Transcranial Direct-Current Stimulation (tDCS) Versus Venlafaxine ER In The Treatment Of Depression: A Randomized, Double-Blind, Single-Center Study With Open-Label, Follow-Up</p>

Possible Facilitative Effects of Repeated Anodal Transcranial Direct Current Stimulation on Functional Outcome 1 Month Later in Schizophrenia: An Open Trial

Transcranial Direct Current Stimulation in Depression and Psychosis: A Systematic Review

Contact Info

Product

Resources

About