A Computational Method for Predicting Inferior Vena Cava Filter Performance on a Patient-Specific Basis

Aycock, Kenneth I.; Campbell, Robert L.; Manning, Keefe B.; Sastry, Shankar Prasad; Shontz, Suzanne M.; Lynch, Frank C.; Craven, Brent A.

doi:10.1115/1.4027612

Cited by 33 publications

(41 citation statements)

References 48 publications

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“…1,7 The veins were modelled as anisotropic, hyperelastic material using the Holzapfel-Gasser-Ogden (HGO) formulation. 2,9,13 Local material directions were assigned to the veins using a cylindrical coordinate system. Since the actual material properties were unknown, average values were obtained on the tensile properties of human IVCs from a published work 26 and fitted to the HGO model to obtain the stressstretch curves.…”

Section: Materials Propertiesmentioning

confidence: 99%

An Experimental and Computational Study on the Effect of Caval Valved Stent Oversizing

Ismail

Kumar

Kabinejadian

et al. 2016

Cardiovasc Eng Tech

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Heterotopic implantation of transcatheter tricuspid valve is a new treatment option for tricuspid regurgitation. Transcatheter tricuspid valves are implanted onto the cavoatrial junction in order to avoid the challenging task of anchoring the valve onto the complex tricuspid valve annulus. However, little is known about optimum extent of oversizing of the valved stent in a vena cava. In this study, we implanted valves of the same diameter onto the larger sized inferior vena cava (IVC) and a smaller sized superior vena cava (SVC). The valve in the IVC was oversized by 10.7% while the valve in the SVC was oversized by 21.6%. Finite element analysis was performed (i) to assess the strain on the nitinol stent during manufacturing and deployment; (ii) the stents were deployed in a patient-specific vena cava model and the intramural stress of the vena cava was calculated computationally. These valves were fabricated and placed in a silicone model of a patient-specific right atrium which was part of a mock circulatory system that emulated the patho-physiological flow rate and pressure of a patient with tricuspid regurgitation. Flow measurements were conducted by particle image velocimetry (PIV). It was found that the maximum crimping strain on the nitinol stent was 6.85% which was lower than the critical threshold of 10%. The maximum stress on the vena cava was located at the spot where the hooks met the wall. The maximum stress on the IVC was 0.5098 MPa while the maximum stress on the SVC was 0.7 MPa. The maximum Reynolds shear stress (mRSS) in the vena cava was found to be higher in the IVC than SVC with the highest mRSS being 1741 dynes/cm(2) found in the region of high flow during the peak flow phase. The overtly oversized valve in the SVC did not cause flow disturbances and exhibited mostly laminar flows. The mRSS at the downstream of the vena cava valve and the middle of the atrium remained at low magnitudes. However, velocity fluctuations were high in the IVC in all the time points measured. In conclusion, oversizing the valve may assist anchorage; yet, careful consideration should be taken in choosing the extent of oversizing as it may lead to adverse effects.

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Section: Materials Propertiesmentioning

confidence: 99%

An Experimental and Computational Study on the Effect of Caval Valved Stent Oversizing

Ismail

Kumar

Kabinejadian

et al. 2016

Cardiovasc Eng Tech

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“…Though blood is a non-Newtonian fluid, (1) showed that the Newtonian approximation introduces less than 10% error in velocities when simulating flow in a simplified IVC geometry (5). The density of the fluid was 1.07g/cm 3 and its viscosity was 0.041g/cms.…”

Section: Fsi Model Properties and Boundary Conditionsmentioning

confidence: 99%

“…Previous experimental and computational studies have investigated the hemodynamic effects of IVC filter placement and embulus capture rate in simplified IVC geometries (5). Many in vitro studies have been performed using optical methods such as particle imagine velocimetry (6; 7; 8; 9; 10).…”

Section: Introductionmentioning

confidence: 99%

Numerical and experimental study of the fluid flow through a medical device

Nicolás

Palero

Peña

et al. 2015

International Communications in Heat and Mass Transfer

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The purpose of this paper is to verify a commercial software based fluid-structure interaction scheme for the inferior vena cava. Vena cava deep thrombosis (TVP) is a potentially deathly disease consequent to pulmonary thromboembolism (TEP).TEP consist in the obstruction of the pulmonary artery due to a blood clot traveling in the cardiovascular system and is treated with anticoagulants and inferior vena cava filters. Flow fields along the vena cava and an antithrombus filter were studied and compared with a Particle Image Velocimetry (PIV) based model to validate the numerical model. The results show that the Fluid Structure Interaction (FSI) models are valid and can be used to study the deformations in the inferior vena cava wall using patient-specific geometries.

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“…Furthermore, most of these works are related only to clinical results or fluid analyses, without addressing the improvement of filter design. While there have been several hemodynamic studies of IVC filters, fewer have been published on the mechanical interaction between the vena cava and metallic filter …”

Section: Introductionmentioning

confidence: 99%

“…While there have been several hemodynamic studies of IVC filters, 4,[19][20][21][22][23][24][25][26][27] fewer have been published on the mechanical interaction between the vena cava and metallic filter. [28][29][30] Analysis of other aspects of filter design such as strut perforation or filter migration are needed to evaluate the effectiveness of filters and develop new device models. In a previous study, García et al 28 evaluated the extraction forces and stress at the end of the struts by an experimental setup and a finite element (FE) simulation without an analysis of the interaction forces between the metallic strut and vena cava tissue.…”

Section: Introductionmentioning

confidence: 99%

Calibration of interface properties and application to a finite element model for predicting vena cava filter–induced vein wall failure

Pérez-Andrés

Peña

2018

Numer Methods Biomed Eng

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We present a computational framework that integrates experimental techniques and finite element modeling to calibrate material fracture parameters of the vena cava and the interaction properties between a retrievable filter (Günther Tulip) and the vena cava wall. The fitted parameters were then used to analyze the interaction of the inferior vena cava filter with the vena cava during the deployment process. An idealized cava finite element model was then developed including residual stresses and physiological pressure conditions. Filter deployment was simulated, and a comprehensive study of tissue-filter interaction was performed by cohesive surface modeling. Simulations predict that there are no fracture areas for either model, so we can conclude that there is no penetration of the anchor into the vena cava. This suggests there are other physiological situations, such as the Valsalva maneuver, which could produce this penetration observed on some patients.

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A Computational Method for Predicting Inferior Vena Cava Filter Performance on a Patient-Specific Basis

Abstract: A computational methodology for simulating virtual inferior vena cava (IVC) filter placement and IVC hemodynamics was developed and demonstrated in two patient

Cited by 33 publications

References 48 publications

An Experimental and Computational Study on the Effect of Caval Valved Stent Oversizing

An Experimental and Computational Study on the Effect of Caval Valved Stent Oversizing

Numerical and experimental study of the fluid flow through a medical device

Calibration of interface properties and application to a finite element model for predicting vena cava filter–induced vein wall failure

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