This study examined the patterns of psychosocial adaptation to chronic illness and disability in a sample of 121 individuals with various physical, sensory, psychiatric, learning, and cognitive disabilities. Indicators of psychosocial adaptation were selected from four broad domains including: (a) disability-associated psychosocial experiences that targetted reactions of anxiety, depression, anger, denial, and adjustment; (b) coping strategies adopted by the individual to mitigate stress engendered by the onset or existence of disabling conditions; (c) perceptions of control over healthrelated issues; and (d) perceived quality of life and overall life satisfaction. Cluster analysis revealed three distinct clusters of respondents that suggested a varying degree of psychosocial adaptation. Accordingly, these clusters were labelled Adaptive (n = 59), Nonadaptive (n = 22), and Intermediately Adaptive (n = 39). Most notably, findings indicated that the Adaptive and Nonadaptive groups differed markedly, and consistently, across all four domains. Those in the Adaptive cluster, as compared to the Nonadaptive cluster, demonstrated lower overall psychological distress, greater reliance on problem-focused coping strategies, more frequent perceptions of personal control over health outcomes, and higher perceived quality of life and overall life satisfaction, as well as lower perceived levels of functional limitations and higher perceived levels of spiritual well-being.