A comprehensive study of extraction of hyperoside from <i>Hypericum perforatum</i> L. using CTAB reverse micelles

Zhou, Xiaohua; Dong, Lichun; Li, Duanhua

doi:10.1002/jctb.1963

Cited by 10 publications

(7 citation statements)

References 19 publications

(8 reference statements)

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“…At the optimum operating conditions, the extraction efficiency can reach 69 to 78% of propolis crude material, been significantly more effective than the conventional methods for propolis extraction. This result was coherent with the work developed by Zhou et al (2008) in which a bioactive flavonol was extracted (in great amount) using reverse micelles (W/O system).…”

Section: Discussionsupporting

confidence: 90%

“…Extraction process using water-in-oil (W/O) microemulsion systems, commonly referred as reverse micelles, has been widely used in purification of biological macromolecules. According to Zhou et al (2008), theoretically, this method can also be used to extract small molecules from natural sources. In fact, using cetyl trimethylammonium bromide (CTAB) reverse micelles it was possible to extract the biological natural product quercetin-3-O-β-galactosidepyranose a kind of flavonoid commonly called hyperoside, that has many biomedical functions, from the natural source Hypericum perforatum L. .…”

Section: Resultsmentioning

confidence: 99%

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Development of a new propolis microemulsion system for topical applications

Dantas¹,

Silva²,

Neto³

et al. 2010

Rev. bras. farmacogn.

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RESUMO: "Desenvolvimento de um novo sistema microemulsionado de própolis para aplicação tópica". Sistemas microemulsionados (MES) oferecem inúmeras vantagens como liberadores de fármacos já que favorecem a absorção do princípio ativo e são, em muitos casos, mais eficientes do que outros métodos de liberação de substâncias bioativas. Neste trabalho, um MES foi obtido visando uma formulação para uso tópico, contendo extrato etanólico de própolis (PEE). Neste estudo, Diagramas de fase pseudoternários foram utilizados para caracterização das regiões de microemulsão, bem como para definição da região de Winsor IV do sistema PEE-MES (Tween 80 como tensoativo e álcool etílico como co-tensoativo, em baixo percentual). Os resultados obtidos indicaram que o melhor sistema microemulsionado contém C/S (cotensoativo/tensoativo) na razão 1,0, fornecendo uma microemulsão do tipo O/A com ampla região de Winsor IV. A formulação PEE-MES poderá vir a ser utilizada comercialmente para uso tópico no combate a inflamações de boca e garganta. Considerando o amplo uso de própolis em formulações convencionais, onde sua solubilidade representa um dos maiores problemas, o sistema PEE-MES disponibiliza este produto natural para aplicações farmacológicas, com boa solubilidade em um sistema microemulsionado do tipo O/A. Adicionalmente, o efeito bactericida do sistema PEE-MES foi comprovado e uma nova metodologia de extração de própolis é apresentada.Unitermos: Própolis, sistema microemulsionado, formulação tópica.ABSTRACT: Microemulsion systems (MES) offer advantages as drug delivery systems, among them favour drug absorption, being in most case more efficient than other methods in delivering of drug. In this work a new MES was obtained in order to be applied as a pressurized aerosol formulation containing bee propolis ethanolic extract (PEE). For that, pseudoternary phase diagrams were used to characterize the microemulsions boundaries and also to define the Winsor IV microemulsion region of the PEE-MES system containing Tween 80 as surfactant and the cosurfactant ethyl alcohol in small percentage. The obtained results indicated that the best MES was composed by Tween 80 and ethyl alcohol with C/S (cosurfactant/surfactant) ratio equal to 1.0, since it provided a large boundaries in the obtained O/W microemulsion region. This PEE-MES formulation, in which bee propolis consisting as oil phase, is herein designed for topical uses (PEE-MES spraying) in order to treat mouth and throat inflammatory infections. Considering the very large uses of bee propolis in conventional vehicles, MES type of delivery system has to be compatible with achieving the highest drug aim loadings, determined substantially by the specific MES application (drug solubilization in water systems) improving in this case, propolis farmacological aplications. Additionally, PEE-MES antibacterial effect was evidenced and the microemulsion system PEE-MES was also used as newest chemical approach for extraction of bee propolis material from resinous hive.

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Section: Discussionsupporting

confidence: 90%

Section: Resultsmentioning

confidence: 99%

Development of a new propolis microemulsion system for topical applications

Dantas¹,

Silva²,

Neto³

et al. 2010

Rev. bras. farmacogn.

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“…In the extraction using ionic reverse micelles with electrostatic interactions as the driving force, the existence of ions in the system always affects the extraction significantly because ions can influence the electrostatic interaction between surfactants and solutes in several ways: salting out effect, screening effect, etc (Huang and Gu, 1996;Zhou et al, 2008). However, in this study, TRPO is a kind of non-ionic surfactant and the driving force of the extraction is the coordination forces.…”

Section: C) Effect Of Ions On Matrine Extractionmentioning

confidence: 88%

Liquid - liquid extraction of matrine using TRPO/cyclohexane reverse micelles

Dong

Zhou

Kang

et al. 2009

Braz. J. Chem. Eng.

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-Reverse micellar extraction has been widely used in the purification of biomolecules. However, reverse micelles formed by ionic surfactants can only be employed for the extraction of biomolecules that are charged in the extraction system with the electrostatic interaction between surfactants and solutes as the driving force. In this study, the extraction of matrine by using reverse micelles formed by non-ionic TRPO surfactants was studied. Theoretical analysis and experimental results demonstrated that the driving force of the extraction is the coordination forces between matrines and TRPOs. Using this coordination-based reverse micellar extraction, matrine can be efficiently separated from oxymatrine and other components in the raw matrine materials. Experimental studies showed that the factors affecting matrine extraction include pH value and TRPO concentration. The existence of ions in the system does not affect the partition coefficient significantly and the addition of a small amount of chloroform in the solution of reverse micelles was found to improve the extraction significantly.

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“…We have known that reverse micelles are nano-scale, transparent, thermodynamically stable assemblies comprising of a surfactant dispersed in a continuous organic phase (14). The centers of the nano-structured surfactant assemblies are described as water pools with a structure similar to that of biological cells.…”

Section: Please Scroll Down For Articlementioning

confidence: 99%

Extraction of L-synephrine by Bis(2-ethylhexyl)phosphoric acid/n-octanol Reversed Micelles

Chen¹,

Li²,

Xu³

et al. 2012

Separation Science and Technology

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In this study, reversed micelles of Bis(2-ethylhexyl)phosphoric acid/n-octanol was prepared to investigate the purification of L-synephrine in Citrus aurantium fruit crude extract. The reverse micellar system formed was confirmed with atomic force microscopy and the effect of important factors on extraction efficiency, such as the pH of the aqueous phase, molar ratio of water to surfactant, surfactant concentration, cationic ion concentration, and extraction time, was studied. Under the optimal operational conditions, the purity of L-synephrine was improved to be >85% and the total yield >98%. Mathematic analysis and experimental results exhibited that the extraction process in this system was effectuated mainly via electrostatic interactions between L-synephrine and the surfactant.

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A comprehensive study of extraction of hyperoside from Hypericum perforatum L. using CTAB reverse micelles

Cited by 10 publications

References 19 publications

Development of a new propolis microemulsion system for topical applications

Development of a new propolis microemulsion system for topical applications

Liquid - liquid extraction of matrine using TRPO/cyclohexane reverse micelles

Extraction of L-synephrine by Bis(2-ethylhexyl)phosphoric acid/n-octanol Reversed Micelles

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