A comprehensive review on synthetic approach for antimalarial agents

Kumar, Ajay; Paliwal, Deepika; Saini, Deepika; Thakur, Aman; Aggarwal, Sanjeev; Kaushik, Dhirender

doi:10.1016/j.ejmech.2014.07.084

Cited by 53 publications

(14 citation statements)

References 166 publications

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“…Synthetic methodologies should be carefully selected, and conditions should be optimized to favor regioselective processes. The literature continuously furnishes updates in synthetic methodologies involving pyrazoles and this topic has been covered in depth by several authors [8,19,[25][26][27]108], including the meticulous and extensive review written by Fustero et al [33].…”

Section: Pyrazoles In Organic Synthesismentioning

confidence: 99%

Revisiting the Structure and Chemistry of 3(5)-Substituted Pyrazoles

2019

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Pyrazoles are known as versatile scaffolds in organic synthesis and medicinal chemistry, often used as starting materials for the preparation of more complex heterocyclic systems with relevance in the pharmaceutical field. Pyrazoles are also interesting compounds from a structural viewpoint, mainly because they exhibit tautomerism. This phenomenon may influence their reactivity, with possible impact on the synthetic strategies where pyrazoles take part, as well as on the biological activities of targets bearing a pyrazole moiety, since a change in structure translates into changes in properties. Investigations of the structure of pyrazoles that unravel the tautomeric and conformational preferences are therefore of upmost relevance. 3(5)-Aminopyrazoles are largely explored as precursors in the synthesis of condensed heterocyclic systems, namely pyrazolo[1,5-a]pyrimidines. However, the information available in the literature concerning the structure and chemistry of 3(5)-aminopyrazoles is scarce and disperse. We provide a revision of data on the present subject, based on investigations using theoretical and experimental methods, together with the applications of the compounds in synthesis. It is expected that the combined information will contribute to a deeper understanding of structure/reactivity relationships in this class of heterocycles, with a positive impact in the design of synthetic methods, where they take part.

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Section: Pyrazoles In Organic Synthesismentioning

confidence: 99%

Revisiting the Structure and Chemistry of 3(5)-Substituted Pyrazoles

2019

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“…Substituted quinolones derivatives are considered as remarkable tools for the eradication of malaria. In order to overcome the challenge of resistance, various heterocycles have also been explored to develop new anti-malarial regents, pyrazolopyridines being one of them (Kumar et al, 2014[ 9 ]). Hybridization concept has been proved as a lead for developing new anti-malarial active agents (Menezes et al, 2002[ 10 ]; Silva et al, 2016[ 14 ]).…”

Section: Introductionmentioning

confidence: 99%

Synthesis and antimalarial potential of some novel quinoline-pyrazolopyridine derivatives

Saini

Jain

Kumar

et al. 2016

EXCLI Journal; 15:Doc730; ISSN 1611-2156

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“…However, children below 5 years of age and pregnant females are at a significantly higher risk of getting affected by this deadly disease [215,216]. In the present era, chemotherapy continues to be the mainstay for the treatment of malaria [217].…”

Section: Antimalarial Activitymentioning

confidence: 99%