A Comprehensive Review on Selenium and Its Effects on Human Health and Distribution in Middle Eastern Countries

Kieliszek, Marek; Bano, Iqra; Zare, Hamed

doi:10.1007/s12011-021-02716-z

Cited by 81 publications

(44 citation statements)

References 179 publications

(217 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Recent geological studies indicated that the nutritional status of selenium depends on the selenium content of soil. Regarding the uneven distribution on Earth, large differences in selenium content are observed between different regions [34][35][36].…”

Section: Discussionmentioning

confidence: 99%

COVID-19 and Selenium Deficiency: a Systematic Review

Fakhrolmobasheri

Mazaheri‐Tehrani

Kieliszek

et al. 2021

Biol Trace Elem Res

Self Cite

View full text Add to dashboard Cite

Several studies have indicated that selenium deficiency may be detrimental in the context of various viral disorders, and in the case of COVID-19, several studies have reported heterogeneous results concerning the association of selenium deficiency with the severity of disease. To summarize the available data surrounding the association of body selenium levels with the outcomes of COVID-19, a systematic search was performed in the Medline database (PubMed), Scopus, Cochrane Library, Embase, and Web of Science using keywords including “SARS-CoV-2,” “COVID-19,” and “selenium,” Studies evaluating the association of COVID-19 with body selenium levels were included. Among 1,862 articles viewed in the database search, 10 articles were included after title, abstract, and full-text review. One study was further included after searching the literature again for any newly published articles. Out of 11 included studies, 10 studies measured serum selenium level, and one study investigated urinary selenium level. Three of 10 studies measured serum SELENOP level as well as selenium level. Glutathione peroxidase-3 level in serum was also assessed in one study. The reported outcomes were severity, mortality, and risk of COVID-19. Nine studies indicated that a lower serum selenium level is associated with worse outcomes. Two studies reported no significant association between serum selenium level and COVID-19. In one study, urinary selenium level was reported to be higher in severe and fatal cases compared to non-severe and recovered patients, respectively. In most cases, selenium deficiency was associated with worse outcomes, and selenium levels in COVID-19 patients were lower than in healthy individuals. Thus, it could be concluded that cautious selenium supplementation in COVID-19 patients may be helpful to prevent disease progression. However, randomized clinical trials are needed to confirm this.

show abstract

Section: Discussionmentioning

confidence: 99%

COVID-19 and Selenium Deficiency: a Systematic Review

Fakhrolmobasheri

Mazaheri‐Tehrani

Kieliszek

et al. 2021

Biol Trace Elem Res

Self Cite

View full text Add to dashboard Cite

show abstract

“…Forages contain Se in concentrations ranging from 0.2 to 0.6 ppm, putting livestock at threat of Se poisoning. Se in wheat plants' seeds is normally stored as selenomethionine (SeMet), with varying levels of Se stored depending on the environment [20]. Compared to other minerals, plants mostly absorb selenite in higher concentrations.…”

Section: Selenium In Plantsmentioning

confidence: 99%

Uses of Selenium Nanoparticles in the Plant Production

et al. 2021

Self Cite

View full text Add to dashboard Cite

Plant production today depends on the ability of agriculturists to transport and recycle minerals, particularly those minerals which are nutritionally important to animals and human beings, through various agriculture products. It is important to note that the attenuation of these mineral deposits by green plants, as well as their subsequent role in the production of organic compounds, is fundamental to almost all known forms of life. Selenium (Se) is among those trace mineral which are crucial for the maintenance of plant physiology. The significance, production, and biological effects of this element, as well as its application in sustainable development, are remaining an interesting topic of discussion. Moreover, there has been a huge rise in the potential applications of nanotechnology in the food and agriculture industries. Several studies have been conducted on the various biological activities of selenium nanoparticles (SeNPs) and their biosynthesis. There is plenty of research performed on the effects of Se in plant nutrition and physiology, but there is a lack of information about the effects of SeNPs in SeNPs toxicity, and other aspects of using SeNPs in agriculture. The current review is focused on recent information related to the effects and fate of SeNPs in agronomy. We also aimed attention at the primary sources and behavior of Se in different environments, such as soil, water, air, and plants. All the data provides an extremely fertile domain for future investigation and research.

show abstract

“…Selenium and its derivatives have pronounced antioxidant properties, even if they are a part of complex compounds. Feeding healthy rats with chlorella algae, which contains a significant amount of selenium, has lowered the levels of lipid peroxidation indicators in the organs and plasma of animals, such as malondialdehyde and diene conjugates, while increasing the levels of indicators of antioxidant protection, such as the activity of superoxide dismutase, succinate dehydrogenase, catalase, and cytochrome-C-oxidase (Krelszek et al 2021).…”

Section: The Important Role Of Selenium and Its Derivativesmentioning

confidence: 99%

“…Selenocysteine and selenomethionine are key forms of selenoproteins and are found in various tissues of the body. Selenocysteine is found in animal tissues, while selenomethionine is obtained from yeast, algae, and some plants (Krelszek et al 2021).…”

Section: The Important Role Of Selenium and Its Derivativesmentioning

confidence: 99%

“…Selenium is one of the most important trace elements in the human body, nutritionally essential as a component of more than two dozen enzymes and other selenoproteins that play critical roles in reproduction, DNA synthesis, thyroid hormone metabolism, and protection from oxidative damage and infection (Rakov and Muz 2019). The human body absorbs more than 90% of selenium from plant and animal food, and about 10% -with drinking water (Krelszek et al 2021). Dietary selenium deficiency can lead to the development of severe and dangerous diseases, such as cardiomyopathy, arrhythmias, and increased susceptibility to infection (Yovanovich and Ermakov 2020).…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Pharmacological properties of selenium and its preparations: from antioxidant to neuroprotector

Бєленічев¹,

Gorchakov²,

Samura³

et al. 2021

RRP

View full text Add to dashboard Cite

Selenium is an essential component of more than two dozen enzymes and other selenoproteins that play critical roles in reproduction, DNA synthesis, thyroid hormone metabolism, and protection from oxidative damage and infection. Selenium has a protective action against some forms of cancer and cardiovascular diseases, modulates levels of inflammatory mediators, promotes to maintain bone homeostasis and protects against bone loss. Selenium significance as a cardioprotective agent may be associated not only with its antioxidant properties, but also with its ability to prevent inflammation, autophagy, as well as the intrinsic and extrinsic apoptosis pathways. Signaling pathways, such as p-AMPK, PARP, Nrf2, STAT, are involved in the protective effects of selenium. Selenium protects against cardiovascular damage by increasing the survival rate of cardiomyocytes, including a mitochondria-dependent pathway and autophagy through peroxisome proliferator-activated receptors. Research demonstrating neuroprotective and cardioprotective effects of selenium preparations – selenoline, selenocysteine and selenomethionine – is growing at a rapid rate. It has been established that these compounds are able to normalize the levels of heat shock proteins (HSP70), which limit the cytotoxic effects of free radicals, produce energotropic action, prevent a decrease in the membrane mitochondria charge, and the opening of the mitochondrial pore. Also regulate the expression of transmembrane factors NF-kB, c-fos, which is associated with their main biological function of chaperone proteins, providing protection of neurons from damage. In this review, we want to emphasize pharmacological role of Selenium and its derivatives on human health is very complex and has yet to be fully understood.

show abstract

A Comprehensive Review on Selenium and Its Effects on Human Health and Distribution in Middle Eastern Countries

Cited by 81 publications

References 179 publications

COVID-19 and Selenium Deficiency: a Systematic Review

COVID-19 and Selenium Deficiency: a Systematic Review

Uses of Selenium Nanoparticles in the Plant Production

Pharmacological properties of selenium and its preparations: from antioxidant to neuroprotector

Contact Info

Product

Resources

About