A Comprehensive Review on Physiological Effects of Curcumin

Ahsan, Rabiya; Ali, Arshad; Khushtar, Mohammad; Ahmad, Mohd Afroz; Muazzam, Mohammad; Akhter, Sohel; Gupta, Gudiya; Muzahid, Mohd

doi:10.1055/a-1207-9469

Cited by 17 publications

(6 citation statements)

References 55 publications

(61 reference statements)

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“…For decades, curcumin and related bioactive curcuminoids (demethoxycurcumin and bisdemethoxycurcumin) have been the center of interest of scientific studies worldwide into their therapeutic potentials. Numerous laboratory studies have documented its antioxidant, anti-inflammatory, antimicrobial, antiviral, antineoplastic and antiaging activities [ 1 , 2 , 3 ]. Curcumin has low bioavailability due to its poor aqueous solubility, low intestinal absorption, low tissue distribution, rapid metabolism and systemic clearance [ 4 ].…”

Section: Introductionmentioning

confidence: 99%

Curcumin-Rich Curry Consumption and Neurocognitive Function from 4.5-Year Follow-Up of Community-Dwelling Older Adults (Singapore Longitudinal Ageing Study)

Nyunt

Gwee

et al. 2022

Nutrients

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The potential neurocognition protective effects of dietary curcumin in curry consumed with food was investigated in this study of 2734 community-dwelling adults (aged ≥ 55, mean ± SD: 65.9 ± 7.4). We analyzed longitudinal data of baseline curry consumption (“never or rarely”, “occasionally”: <once a month, “often”: >once a month and <once a week, “very often”: >once a week or daily) and baseline and 4.5-year follow-up cognitive function in mixed model analyses controlling for confounding risk factors. Significant between-exposure differences were found for Digit Span-Backward (DS-B), Verbal Fluency-Animals (VF-A) and Block Design (BD). Compared to “never or rarely” consumption, “very often” and “often” consumptions were associated with higher DS-B performance; “very often”—with higher VF-A, and “occasional”, “often” and “very often” consumptions—with higher BD: Cohen’s d: from 0.130 to 0.186. Among participants with cardiometabolic and cardiac diseases (CMVD), curry consumption was associated with significantly higher DS-B and VF-A. Among CMVD-free participants, curry consumption was associated with significantly higher DS-B, VF-A and BD: Cohen’s d: from 0.098 to 0.305. The consumption of dietary curcumin was associated with the maintenance over time of higher functioning on attention, short-term working memory, visual spatial constructional ability, language and executive function among community-dwelling older Asian adults.

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Section: Introductionmentioning

confidence: 99%

Curcumin-Rich Curry Consumption and Neurocognitive Function from 4.5-Year Follow-Up of Community-Dwelling Older Adults (Singapore Longitudinal Ageing Study)

Nyunt

Gwee

et al. 2022

Nutrients

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“…However, based on the findings, the colorant's risk of causing an allergic reaction appeared to be low. [31] Curcumin was given orally to rats at levels up to 5 g/kg with no obvious evidence of harm. Turmeric is classified as a menstruation stimulant by the American Herbal Association, and some sites advise against using curcumin during pregnancy.…”

Section: Toxicological Aspects Of Curcuminmentioning

confidence: 99%

“…Long-term clinical trials with larger numbers of patients are required to further clarify these effects of turmeric. [30,31]…”

Section: Lupus Nephritis Treatmentmentioning

confidence: 99%

Untitled

2022

IJGP

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Turmeric (Curcuma longa) is used as a spice, preservative, and coloring matter and has a wide range of medicinal and pharmacological applications. Curcumin, a polyphenolic herbal product, well-known shows healing hobby for some of the diseases, attributed specially to its chemical shape and specific physical, chemical, and organic properties. The oxidative damage and inflammation have been pointed out as the root cause of many chronic diseases such as cancer, diabetes, hypertension, and Alzheimer's disease. Curcumin and its analogs prevent oxidative damage and inhibit the binding of toxic metabolites to DNA. The safety studies indicate that turmeric is well tolerated at a very high dose (0.5-1.5 g/day/person) without any toxic effects. Epidemiological and clinical studies of curcumin suggested that cancer could be prevented or significantly reduced by treatment with antioxidant and anti-inflammatory drugs, therefore, Curcumin, an anti-oxidant and anti-inflammatory compound found in turmeric (a curry spice), could be a promising option for the prevention and/or treatment of cancer and other chronic diseases. Curcumin, a highly pleiotropic drug with a great safety profile and strong molecular evidence targeting various diseases, could not attain its optimal therapeutic effect in previous clinical studies, owing to its limited solubility and poor absorption. Curcumin can be developed as a medicinal medication by enhancing its absorption and cellular uptake through better formulation qualities or delivery mechanisms. This review focuses on the properties, chemistry, toxicity studies, dosage, and the possibilities of the therapeutic application of curcumin for the prevention and/or treatment of several diseases, and their safety profile.

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“…Curcumin is a polyphenolic compound extracted from the rhizomes of Zingiberaceae that has the superior properties of promoting fibroblast proliferation and differentiation and anti‐inflammatory properties, which are closely related to skin wound healing [7,8]. Curcumin causes myofibroblasts to accumulate at the wound site, allowing myofibroblasts to appear in the wound [9‐11].…”

Section: Introductionmentioning

confidence: 99%

Localized delivery of curcumin by thermosensitive hydrogels for promoting wound healing

Zhang

Chen

Shen

et al. 2022

J of Cosmetic Dermatology

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Background Curcumin can promote wound healing, but its drug delivery medium needs to be improved further. Objectives A curcumin‐loaded thermosensitive hydrogel was prepared, its characterization was evaluated, and its promoting effect on wound healing was observed. Methods Curcumin‐loaded thermosensitive hydrogels were prepared with different percentages of poloxamer 188 and poloxamer 407. A small tube inversion assay was used to observe the sol‐gel transition temperature, and a rotational rheometer was used to detect the sol viscosity, sol‐gel phase transition temperature, and phase transition time. The microstructure of the gel was observed by scanning electron microscopy, and Fourier infrared spectroscopy was used to evaluate whether curcumin was successfully loaded. Finally, its promoting effect on wound healing was observed in vivo and in vitro. Results Poloxamer 407 24% and poloxamer 188 1% were selected to prepare curcumin‐loaded thermosensitive hydrogels. After 60 ± 15 s at 32°C, the sol‐gel transition process was completed, with certain elastic behavior and solid‐like rheological properties. Scanning electron microscopy showed that the pores of the curcumin‐P407/P188 thermosensitive hydrogel were interconnected, with an average pore size ranging from 5 to 10 μm. Hydrogels showed a higher swelling ratio. Fourier transform infrared spectroscopy showed that curcumin had been incorporated into the hydrogel. Live/dead cell assays suggested that the hydrogel was not toxic to fibroblasts. Curcumin‐loaded thermosensitive hydrogels can promote an increase in S‐phase fibroblasts and improve wound healing. Conclusions Curcumin‐loaded P407/P188 thermosensitive hydrogel improves wound healing. More in‐depth research is needed in the future.

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A Comprehensive Review on Physiological Effects of Curcumin

Cited by 17 publications

References 55 publications

Curcumin-Rich Curry Consumption and Neurocognitive Function from 4.5-Year Follow-Up of Community-Dwelling Older Adults (Singapore Longitudinal Ageing Study)

Curcumin-Rich Curry Consumption and Neurocognitive Function from 4.5-Year Follow-Up of Community-Dwelling Older Adults (Singapore Longitudinal Ageing Study)

Untitled

Localized delivery of curcumin by thermosensitive hydrogels for promoting wound healing

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