A Comprehensive Review on Cu‐Catalysed Aerobic Oxidation of Amines to Imines

Abstract

Imines are frequently used as valuable intermediates in organic transformation and pharmaceutical synthesis. Conventional imine synthesis includes Lewis acid catalysts, dehydrating agents, and unstable aldehydes. Developing eco‐friendly molecular assembly techniques has become increasingly important in recent years. In particular, there is a significant need for methods that recycle resources and have high atomic efficiency with minimal environmental impact. Oxidative synthesis of imines from amines has been investigated in presence of molecular oxygen (or air) which is readily accessible on Earth. The closely linked catalysts have been classified into metals, bio‐inspired, and MOF catalysts. Highly active, affordable, and adaptable copper based catalysts are given special attention here, some critical elements that influence reaction processes and catalytic activity are also displayed in the present study. The modern methods along with mechanistic routes for converting primary amines to imines using copper catalytic systems and ambient oxygen have been discussed in detail.

Photoinduced Nitroarenes as Versatile Anaerobic Oxidants for Accessing Carbonyl and Imine Derivatives

“…Then, we investigated if amines ( 2 ) − could be oxidized in the presence of photoexcited nitroarenes (Table A, 2 → 4 ). Exposure of conditions A and B to dibenzyl amine 2a resulted in a low yield of the desired oxidation product 4a .…”

Photoinduced Nitroarenes as Versatile Anaerobic Oxidants for Accessing Carbonyl and Imine Derivatives

“…With the success of oxidizing alcohols, we investigated if amines (2) [29][30][31] could be oxidized in the presence of photoexcited nitroarenes (Table 1A, 2®4). Exposure of conditions A and B to dibenzyl amine 2a resulted in a low yield of the desired oxidation product 4a.…”