A comprehensive review on antiepileptic properties of medicinal plants

Faheem, Muhammad; Ameer, Sara; Khan, Abdul Waheed; Haseeb, Muhammad; Raza, Qurratulaen; Shah, Fawad Ali; Khusro, Ameer; Aarti, Chirom; Sahibzada, Muhammad Umar Khayam; Batiha, Gaber El‐Saber; Koirala, Niranjan; Adnan, Muhammad; Alghamdi, Saad; Assaggaf, Hamza; Alsiwiehri, Naif

doi:10.1016/j.arabjc.2021.103478

Cited by 18 publications

(11 citation statements)

References 167 publications

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“…Hence, these compounds, i.e., berbamine (BBM), bergapten (BRG), and carveol (CAR), as shown in Figure 1 , are explored for their potential therapeutic use in the neuropathic pain from STZ-induced diabetes. Natural compounds exhibit promising neuroprotective potential, as per recently published literature ( Faheem et al, 2022a ). Berbamine (BBM) is a bisbenzylisoquinoline alkaloid from Berberis amurensis Rupr.…”

Section: Introductionmentioning

confidence: 52%

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Investigation of Natural Compounds for Therapeutic Potential in Streptozotocin-induced Diabetic Neuroinflammation and Neuropathic Pain

Faheem

Khan²,

Shah³

et al. 2022

Front. Pharmacol.

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Diabetic neuropathy (DN) is a serious microvascular complication of diabetes mellitus (DM) that impacts the nervous system. Several risk factors are involved in the progression and maintenance of DN-associated pain, such as higher expression of various inflammatory mediators, e.g., tumor necrotic factor-alpha (TNF-α), nuclear factor-kappa B (NF-κB), and cyclo-oxygenase-2 (COX-2). The present research explores the neuroprotective potential of natural isolates, including berbamine, bergapten, and carveol, on the DM-induced neuroinflammation and neurodegeneration that cause neuropathic pain. The study utilized computerized techniques, including computational analysis (a docking assay and a molecular dynamic simulation) before moving to in vivo protocols. Diabetic neuropathy was induced by intraperitonial injection (IP) of streptozotocin (65 mg/kg), and the animal subjects (rats) were kept for 4 weeks for the development of DN. Once diabetic neuropathy was confirmed, the subjects were treated with berbamine, bergapten, and carveol until the sixth week (i.e., 2 weeks of treatment). At the sixth week, the rats were sacrificed, and the sciatic nerve and spinal cord of each was collected for further molecular investigation. Docking and a molecular dynamic simulation (MDS) delivered the information that the natural compounds (berbamine, bergapten, and carveol) were interacting with the selected target protein (i.e., mitogen-activated protein kinase). After IP, it was found that berbamine, bergapten, and carveol had ameliorated mechanical allodynia and thermal hyperalgesia by the 28th day of the study (2 weeks after treatment) without affecting blood glucose levels. Berbamine, bergapten, and carveol markedly elevated the levels of glutathione (GSH) and glutathione s-transferase (GST), in both the sciatic nerve and spinal cord, and also reduced lipid peroxidase (LPO) and nitric oxide (NO). The abovementioned natural isolates reduced pathologic alterations provoked through DN, a finding confirmed through histopathological assays (hematoxylin and eosin staining and immuno-histochemical analysis). Treatment down regulated higher expressions of the inflammatory mediatorcyclooxygenase-2 (COX-2), tumor necrosis factor-α (TNF-α), and nuclear factor kappa B (NF-κB), as confirmed by ELISA and polymerase chain reaction (PCR). The outcomes of berbamine, bergapten, and carveol are compared with those of pregabalin as a positive control group. Compared to pregabalin, treatment with the aforementioned three natural compounds improved nociception and reduced hyperalgesic effects, and consequently reduced pain perception and inflammation. Our results suggest the mechanism for the neuro-protective impact of berbamine, bergapten, and carveol might possibly be arbitrated via COX-2, TNF-α, and NF-κB, and regulated by mitogen-activated protein kinase, ultimately ameliorating STZ-provoked, DM-induced neuroinflammation and neurodegeneration, and associated neuropathic pain.

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Section: Introductionmentioning

confidence: 52%

“…The readings were taken 3 times by repeating the procedure. The resultant values of the inflammatory markers were expressed in picograms per milliliter to the overall protein content ( Faheem et al, 2022a ).…”

Section: Methodsmentioning

confidence: 99%

Investigation of Natural Compounds for Therapeutic Potential in Streptozotocin-induced Diabetic Neuroinflammation and Neuropathic Pain

Faheem

Khan²,

Shah³

et al. 2022

Front. Pharmacol.

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“…They face certain stressors such as peer pressure, environmental demands; social and emotional difficulties and these problems directly affect their wellbeing [18]. If they are unable to cope up with these stressors then they are most likely to experience anxiety and suffer from mental issues (i.e., interpersonal problems, aggression, low confidence and less self-esteem), which may cause more deterioration in their overall adjustment [15,19].…”

Section: Discussionmentioning

confidence: 99%

Anxiety, Social Adjustment and Psychological well-being of blind Adolescents

Akram¹,

Hassan²,

Mazhar³

et al. 2022

PJMHS

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Objective: The objective of the study was to assess anxiety as predictor of social adjustment and psychological wellbeing in blind adolescents. The present study examined the level of anxiety, social adjustment and psychological wellbeing of blind adolescents. Methodology: Cross sectional research design was used in the study. The study was carried out on the sample of 150 blind adolescents between the ages of 12 to 18 years. Demographic variables were also considered in analyses to examine their influences. The tools related to anxiety, psychological wellbeing and social adjustment were used. Urdu version of beck anxiety inventory (1988), social adjustments scale (Mundt et al., 2002) and psychological wellbeing scale (Ryff, 1989) was used. Results: Independent t-test, Correlation and multiple Regression analyses were run to test the hypotheses. Independent t-test showed that the level of anxiety is comparatively greater in females than males, t (148) = -1.15, p= .25.”. Correlation analysis showed that there is significant negative correlation among anxiety and psychological well-being of the blind adolescents, r = - 0.21, *p<0.05 and there is significant positive correlation among anxiety and social adjustment, r=0.283, *p<0. 05.. A regression was calculated to predict the social adjustment from Anxiety), β=.283, t=18.457, p<.000, R²=.080. Regression was calculated to predict the psychological well- being from Anxiety, β = .214, t = 48.640, p < .000, R²=.046. Regression analysis demonstrated anxiety as a significant predictor of psychological wellbeing and social adjustment in blind adolescents. Conclusion: The rationale of the research was to observe the level of anxiety, societal adjustment and psychological wellbeing of blind adolescents. The study revealed that anxiety is increased in blind females’ adolescent than blind male’s adolescent and there is negative relationship among anxiety, social adjustment and psychological well-being of blind adolescents. According to the current research, anxiety can be predictor of social adjustment and psychological well-being of blind adolescents. It can be concluded that anxiety has an impact on the social adjustment of blind adolescents which further leads to impairment in psychological and social functioning especially in adolescence.

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“…Traditionally, rosemary leaves have been used against muscle, joint and rheumatism pain [ 4 ], as a stimulant and diaphoretic and for its flatulence-relieving properties [ 5 , 6 ]. Headaches, epilepsy, dysmennorhea, inflammation and spasmolytic conditions were also treated with rosemary [ 7 , 8 ]. Nowadays rosemary is among the most studied medicinal plants and its essential oil and extracts’ therapeutic activity has been evaluated against various diseases [ 9 , 10 ].…”

Section: Introductionmentioning

confidence: 99%

Cytotoxic Effect of Rosmarinus officinalis Extract on Glioblastoma and Rhabdomyosarcoma Cell Lines

et al. 2022

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Rosmarinus officinalis is a well-studied plant, known for its therapeutic properties. However, its biological activity against several diseases is not known in detail. The aim of this study is to present new data regarding the cytotoxic activity of a hydroethanolic extract of Rosmarinus officinalis on glioblastoma (A172) and rhabdomyosarcoma (TE671) cancer cell lines. The chemical composition of the extract is evaluated using liquid chromatography combined with time-of-flight mass spectrometry, alongside its total phenolic content and antioxidant activity. The extract showed a promising time- and dose-dependent cytotoxic activity against both cell lines. The lowest IC50 values for both cell lines were calculated at 72 h after treatment and correspond to 0.249 ± 1.09 mg/mL for TE671 cell line and 0.577 ± 0.98 mg/mL for A172 cell line. The extract presented high phenolic content, equal to 35.65 ± 0.03 mg GAE/g of dry material as well as a strong antioxidant activity. The IC50 values for the antioxidant assays were estimated at 12.8 ± 2.7 μg/mL (DPPH assay) and 6.98 ± 1.9 μg/mL (ABTS assay). The compound detected in abundance was carnosol, a phenolic diterpene, followed by the polyphenol rosmarinic acid, while the presence of phenolic compounds such as rhamnetin glucoside, hesperidin, cirsimaritin was notable. These preliminary results suggest that R. officinalis is a potential, alternative source of bioactive compounds to further examine for abilities against glioblastoma and rhabdomyosarcoma.

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A comprehensive review on antiepileptic properties of medicinal plants

Cited by 18 publications

References 167 publications

Investigation of Natural Compounds for Therapeutic Potential in Streptozotocin-induced Diabetic Neuroinflammation and Neuropathic Pain

Investigation of Natural Compounds for Therapeutic Potential in Streptozotocin-induced Diabetic Neuroinflammation and Neuropathic Pain

Anxiety, Social Adjustment and Psychological well-being of blind Adolescents

Cytotoxic Effect of Rosmarinus officinalis Extract on Glioblastoma and Rhabdomyosarcoma Cell Lines

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