A comprehensive review of the antibacterial activity of dimethylaminohexadecyl methacrylate (DMAHDM) and its influence on mechanical properties of resin-based dental materials

Oliveira, Francisca Jennifer Duarte de; Filho, Paulo Sérgio Ferreira da Silva; Costa, Moan Jéfter Fernandes; Caldas, Marília Regalado Galvão Rabelo; Borges, Boniek Castillo Dutra; Araújo, Diana Ferreira Gadelha de

doi:10.1016/j.jdsr.2021.03.003

Cited by 19 publications

(8 citation statements)

References 83 publications

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“…The presence of bacteria is an important factor affecting tooth lifespan. The fundamental mechanism of a tooth damaged by bacteria is demineralization produced by the acid assault of bacteria in the tooth biofilm . For the quaternized carbamate antibacterial mechanism, first, positively charged polymer quaternized ammonium salt is adsorbed to the surface of the thallus through electrostatic gravity and then polymer segments penetrate the cell wall and combine with the protein and lipid layers in the cell membrane.…”

Section: Resultsmentioning

confidence: 99%

“…The fundamental mechanism of a tooth damaged by bacteria is demineralization produced by the acid assault of bacteria in the tooth biofilm. 9 For the quaternized carbamate antibacterial mechanism, first, positively charged polymer quaternized ammonium salt is adsorbed to the surface of the thallus through electrostatic gravity and then polymer segments penetrate the cell wall and combine with the protein and lipid layers in the cell membrane. Ultimately, quaternized ammonium salt affects the substance exchange process between the thallus and the outside world and causes the leakage of intracellular substances.…”

Section: Mbc Measurement Of Puaqassmentioning

confidence: 99%

“…Antibacterial performance is one of the necessary properties of dental materials. Acid substances produced by bacteria can corrode the materials, cause the loss of calcium and phosphorus, and shorten the service life of tooth materials. , Quaternary ammonium salt is commonly used as a bactericide for dental materials, which can resist most bacteria and has high antibacterial activity. , However, the formerly used quaternary ammonium salt antibacterial agents are non-polymerizable small molecules with cytotoxicity, poor biocompatibility, and incompatibility with matrix materials.…”

Section: Introductionmentioning

confidence: 99%

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Photochemically Driven Polymeric Biocompatible and Antimicrobial Thiol–Acrylate Nanocomposite Suitable for Dental Restoration

Zhou

Zhao

et al. 2022

ACS Appl. Mater. Interfaces

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The development a photochemically driven polymeric composite for dental restorative materials to restore tooth cavities with antibacterial, biocompatibility, and outstanding mechanical properties is an urgent need for clinical application in stomatology. Herein, a series of polyurethane acrylate (PUA) prepolymers and antibacterial polyurethane acrylate quaternary ammonium salts (PUAQASs) were synthesized, and their mechanical and biological properties were explored. The unique secondary mercaptan with a long shelf life and low odor was used to reduce oxygen inhibition and increase cross-linking density; meanwhile, modified photocurable nano zirconia (nano ZrO 2 ) enhances mechanical properties of the nanocomposites and possesses preeminent dispersion in the matrix. The results show that minimal inhibitory concentrations (MICs) of PUAQASs are 200 and 800 μg/mL for Staphylococcus aureus and Escherichia coli, respectively. The addition of secondary thiols significantly increases the photopolymerization rate and monomer conversion. The highest hardness and modulus reach 1.8 and 8.7 GPa compared to 1.8 and 8.3 GPa for commercial resin. The lap shear stress on the pig bone is 912 MPa, and that on commercial resin is 921 MPa. Most importantly, the photochemically driven polymeric composite has excellent biocompatibility and significantly better antimicrobial properties than commonly used commercial resins.

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Section: Resultsmentioning

confidence: 99%

Section: Mbc Measurement Of Puaqassmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Photochemically Driven Polymeric Biocompatible and Antimicrobial Thiol–Acrylate Nanocomposite Suitable for Dental Restoration

Zhou

Zhao

et al. 2022

ACS Appl. Mater. Interfaces

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“…Introducing rechargeable composite with nanoparticles of amorphous calcium phosphate was also attempted. Composite containing MPC and DMAHDM greatly reduced biofilm growth and lactic acid production, without compromising mechanical properties of the composite [15,22].…”

Section: Resultsmentioning

confidence: 99%

The state-of-the-art validity of using methacryloyloxyethyl compounds in dentistry

Pavlov

Ibrahim²

2021

Advances in Clinical and Experimental Dentistry

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Background Methacryloyloxyethyl compounds, including 2-Methacryloyloxyethyl phosphorylcholine (MPC), is now used in dentistry given their biological compatibility and anti-bacterial properties.Objective This overview highlights the recent advances methacryloyloxyethyl derivatives have brought into dentistry.Results PC is a biocompatible and hydrophilic biomedical polymer, which is ventured into operative dentistry, orthodontics and endodontics. Its use is always enhanced with another chemical derivative or nanoparticles. Advances in KnowledgeThe effect of incorporation of a protein repellent agent into soft lining material on biofilm formation has not been reported. Therefore, this study investigated the reported findings regarding the influence of adding MPC in different ratios to the powder of soft denture liner to benefit from its excellent ability to repel protein adsorption and prevent bacterial adhesion. Adhesive dentistry has improved resin composite with MPC and dimethylaminohexadecyl methacrylate for enhancing the inhibitory effect on secondary caries.

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“…Thus, cell membrane permeability is changed, and the target bacteria dissolve and die [ 122 ]. At present, these naturally used QAC monomers include dimethyl hexadecyl methacryloxyethyl iodide (DHMAI), dimethylaminohexadecyl methacrylate (DMAHDM), 12-methacryloyloxy dodecylpyridinium bromide (MDPB), methacryloyloxyethyl hexadecyl ammonium chloride (DMAE-CB) and so forth [ 121 , 123 , 124 ]. They have a stable structure and remarkable antibacterial effect.…”

Section: Ways To Reduce Biodegradationmentioning

confidence: 99%

Biodegradation of Dental Resin-Based Composite—A Potential Factor Affecting the Bonding Effect: A Narrative Review

Guo

Gao

et al. 2022

Biomedicines

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In recent years, although resin composite has played an important role in the restoration of tooth defects, it still has several disadvantages, including being biodegraded by saliva, bacteria and other enzymes in the oral cavity, which may result in repair failure. This factor is not conducive to the long-term survival of the prosthesis in the mouth. In this article, we review the causes, influencing factors and prevention methods of resin biodegradation. Biodegradation is mainly caused by esterase in saliva and bacteria, which breaks the ester bond in resin and causes the release of monomers. The mechanical properties of the prosthesis can then be affected. Meanwhile, cathepsin and MMPs are activated on the bonding surface, which may decompose the dentin collagen. In addition, neutrophils and residual water on the bonding surface can also aggravate biodegradation. Currently, the primary methods to prevent biodegradation involve adding antibacterial agents to resin, inhibiting the activity of MMPs and enhancing the crosslinking of collagen fibers. All of the above indicates that in the preparation and adhesion of resin materials, attention should be paid to the influence of biodegradation to improve the prosthesis’s service life in the complex environment of the oral cavity.

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A comprehensive review of the antibacterial activity of dimethylaminohexadecyl methacrylate (DMAHDM) and its influence on mechanical properties of resin-based dental materials

Cited by 19 publications

References 83 publications

Photochemically Driven Polymeric Biocompatible and Antimicrobial Thiol–Acrylate Nanocomposite Suitable for Dental Restoration

Photochemically Driven Polymeric Biocompatible and Antimicrobial Thiol–Acrylate Nanocomposite Suitable for Dental Restoration

The state-of-the-art validity of using methacryloyloxyethyl compounds in dentistry

Biodegradation of Dental Resin-Based Composite—A Potential Factor Affecting the Bonding Effect: A Narrative Review

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