A comprehensive review of phytochemistry, pharmacology and clinical applications of Uncariae Ramulus Cum Uncis

Zhang, Zilong; Li, Yuze; Wu, Guoqing; Li, Yiming; Zhang, Dongdong; Wang, Rui

doi:10.1016/j.arabjc.2023.104638

Cited by 4 publications

(6 citation statements)

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“…Rhynchophylline, a type of alkaloids found in Uncaria tomentosa, Uncaria attenuata, Uncarua macrophylla, Uncaria rhynchophylla, Uncaria borneensis, Uncaria longiflora var. pteropoda, Uncaria acida, Uncaria africana, Ucnaria bernaysii, Uncaria cordata, Uncaria elliptica, Uncaria kunstleri, Uncaria guianensis, Uncaria sessilifructus, Uncaria sterrophylla, and Uncaria sinensis [25], [45], provides an impact on p38, extracellular signal-regulated kinases (ERK), JNK, cyclic adenosine monophosphate response element-binding protein (CREB), AKT and signal transducer and activator of transcription 3 (STAT3) signaling and augmenting the phosphorylation of p53 [38], [45], decreases C-X-C chemokine receptor 4 (CXCR4) expression [69], and activates the PI3K/AKT signaling pathway [70]. The mitogenactivated protein kinase (MAPK) pathway, which includes p38, ERK, and JNK, is influenced by rhynchophylline by activating p38 and JNK and inhibiting ERK, thereby inducing apoptosis [89], [90].…”

Section: Hirsutinementioning

confidence: 99%

Uncaria-derived alkaloids: A review on the mechanism in inducing apoptosis in oral squamous cell carcinoma

Ridho,

Ulfah,

Aruan

et al. 2024

IJPT

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Alkaloids, the major secondary metabolite compounds identified in the genus Uncaria, exhibit the ability to induce apoptosis in oral squa-mous cell carcinoma (OSCC). Various potential alkaloids in herbal medicine have been explored and provided promising results, one of which is the potential to induce apoptosis. This study aims to provide a more comprehensive review of the mechanism of alkaloids derived from Uncaria in inducing apoptosis in OSCC. In the systematic search conducted, the Preferred Reporting Items for Systematic Reviews and Meta-Analysis (PRISMA) guidelines were adhered to conduct this review through the databases, including PubMed, ScienceDirect, Wiley and a manual search using Google Scholar. According to the findings, this review states that several types of alkaloids derived from Uncaria that have been reviewed, such as hirsutine, rhynchophylline, isorhynchophylline, and hirsuteine, have different mechanisms in in-ducing apoptosis in OSCC, both through intrinsic and extrinsic pathways. The evidence presented in the present study provides an oppor-tunity for future research to determine the appropriate therapeutic dose based on the specific alkaloid, duration of therapeutic administration, and in vivo and/or in human testing.

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Section: Hirsutinementioning

confidence: 99%

Uncaria-derived alkaloids: A review on the mechanism in inducing apoptosis in oral squamous cell carcinoma

Ridho,

Ulfah,

Aruan

et al. 2024

IJPT

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“…A s a traditionally cultivated and widely consumed Chinese medicinal plant, the genus Uncaria produces a wide array of secondary metabolites. 1 To date, more than 350 molecules have been isolated and identified from this genus. Among them, the monoterpene indole alkaloids and oxidized monoterpene indole alkaloids, such as hirsuteine (1) 2 and rhynchophylline (2), 3 are considered the main constituents (Figure 1).…”

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confidence: 99%

“…As a traditionally cultivated and widely consumed Chinese medicinal plant, the genus Uncaria produces a wide array of secondary metabolites . To date, more than 350 molecules have been isolated and identified from this genus.…”

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confidence: 99%

“…Structurally, rhynchines A−E possess a complex 6/5/7/5/5 pentacyclic ring system, a 2-oxa-8-azatricyclo[6,5,0 1,5 ,0 1,8 ]tridecane core, four consecutive stereogenic centers, and a rare N,O-bridged ketone quaternary carbon center. These structural characteristics pose substantial challenges for the total synthesis of these molecules, as no synthetic reports have been established since their isolation.…”

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Bioinspired Collective Total Synthesis of (±)-Rhynchines A–E

Guo,

Shao,

et al. 2024

Org. Lett.

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Herein, we present the first racemic total synthesis of the structurally complex monoterpene indole alkaloids rhynchines A−E, starting from commercially available methyl nicotinate and 3-(2-bromoethyl)-1H-indole. The success of our synthesis is attributed to the utilization of a bioinspired synthetic strategy, which facilitated the rapid construction of the pentacyclic core skeleton of the target molecules through biomimetic skeletal rearrangement and late-stage C−H oxidative cyclization. Additionally, silica-gel-promoted tautomerization played a crucial role as a strategic element in the chemical synthesis of rhynchines A and B.

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“…All of these compounds showed inhibition of PLCγ1 with an IC50 of 9.5-44.6 μM. [10][11][12] There has not been much research regarding the cytotoxic activity of U. nervosa Elmer. Rahmawati (2023), reported the cytotoxic activity of U. nervosa Elmer ethanol extract against T47D breast cancer cells with strong activity category and IC50 of 64.42 µg/mL.…”

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confidence: 99%

Cytotoxic Activity, Cell Migration and Apoptosis Effects of Uncaria nervosa Elmer Leaf Fractions on MCF-7 HER 2 Cells

2024

TJNPR

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A comprehensive review of phytochemistry, pharmacology and clinical applications of Uncariae Ramulus Cum Uncis

Cited by 4 publications

References 100 publications

Uncaria-derived alkaloids: A review on the mechanism in inducing apoptosis in oral squamous cell carcinoma

Uncaria-derived alkaloids: A review on the mechanism in inducing apoptosis in oral squamous cell carcinoma

Bioinspired Collective Total Synthesis of (±)-Rhynchines A–E

Cytotoxic Activity, Cell Migration and Apoptosis Effects of Uncaria nervosa Elmer Leaf Fractions on MCF-7 HER 2 Cells

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