A comprehensive review of chemokine CXC17 (VCC1) in cancer, infection, and inflammation

Shabgah, Arezoo Gowhari; Jadidi‐Niaragh, Farhad; Ebrahimzadeh, Farnoosh; Mohammadi, Hamed; Askari, Elham; Pahlavani, Naseh; Malekahmadi, Mahsa; Nik, Maryam Ebrahimi; Navashenaq, Jamshid Gholizadeh

doi:10.1002/cbin.11846

Cited by 4 publications

(2 citation statements)

References 60 publications

(106 reference statements)

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“…In our study, CXCL17, ST6GALNAC1, and FAM83E were higher in the low-risk group and were related to a good prognosis. In malignant tumors, CXCL17 can promote angiogenesis, metastasis, and cell proliferation [25]. In HNSCC, CXCL17 expression is lower than in normal tissue, and higher levels of CXCL17 mRNA are positively correlated with relapse-free survival and OS [26].…”

Section: Discussionmentioning

confidence: 99%

Prognosis and Dissection of the Immune Microenvironment in Head and Neck Squamous Cell Carcinoma Based on Fatty Acid Metabolism-Related Signatures

Liang

Huang

Xiao

et al. 2023

Preprint

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Background Research has shown that reprogramming of fatty acid metabolism (FAM) is involved in tumorigenicity and cancer progression, as well as the impact of tumor immune microenvironments (TME) on tumorigenesis, metastasis, and the prognosis of head and neck squamous cell carcinoma (HNSCC). However, no reliable molecular markers based on fatty acid metabolism have been identified to predict prognosis, immune infiltration, and treatment in HNSCC.Methods In the HNSCC samples of TCGA, we performed a consensus clustering algorithm to separate molecular subtypes. And then we established a risk model for prognosis with Cox regression and the least absolute shrinkage and selection operator (LASSO) regression. The predictive efficacy of risk model was also verified by another HNSCC cohort from GEO.We also evaluated the risk score association with the clinicopathological features and explored differences of immune cell infiltration, immune status and chemotherapeutic drugs IC 50 value concentration between high and low risk subgroup.Results Three distinct fatty acid metabolism subtypes were identified among 494 HNSCC samples, which were also associated with different clinical outcomes, TME characteristics and clinical features. 9 prognosisrelated genes which were different expressed among three subgroups were screened out for prognostic signature. According to the risk score caculated by the signature genes, patients in TCGA cohort can be divided into high and low risk score subgroups. The low risk score subgroup patients displayed a better prognosis. Further analysis indicated that low risk score correlated with higher immune cells infiltration. In addition, patients with higher risk scores showed a better chemotherapy sensetivity of cisplatin and docetaxel.Conclusions We developed a signature capable of predicting prognosis, representing the TME, enhancing individualized therapy, and providing a novel immunotherapeutic marker in HNSCC.

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Section: Discussionmentioning

confidence: 99%

Prognosis and Dissection of the Immune Microenvironment in Head and Neck Squamous Cell Carcinoma Based on Fatty Acid Metabolism-Related Signatures

Liang

Huang

Xiao

et al. 2023

Preprint

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“…Although most tumors downregulate the expression of chemerin, the potential pro- and anti-tumor activities of this molecule have been reported in the TME and have been suggested as a prognosis marker ( 129 ). More information on this topic is beyond the scope of this review; however, further information can be obtained from previous studies ( 130 , 131 ).…”

Section: Participation Of the Immune Response In Cancermentioning

confidence: 99%

The systemic-level repercussions of cancer-associated inflammation mediators produced in the tumor microenvironment

et al. 2022

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The tumor microenvironment is a dynamic, complex, and redundant network of interactions between tumor, immune, and stromal cells. In this intricate environment, cells communicate through membrane–membrane, ligand–receptor, exosome, soluble factors, and transporter interactions that govern cell fate. These interactions activate the diverse and superfluous signaling pathways involved in tumor promotion and progression and induce subtle changes in the functional activity of infiltrating immune cells.The immune response participates as a selective pressure in tumor development. In the early stages of tumor development, the immune response exerts anti-tumor activity, whereas during the advanced stages, the tumor establishes mechanisms to evade the immune response, eliciting a chronic inflammation process that shows a pro-tumor effect.The deregulated inflammatory state, in addition to acting locally, also triggers systemic inflammation that has repercussions in various organs and tissues that are distant from the tumor site, causing the emergence of various symptoms designated as paraneoplastic syndromes, which compromise the response to treatment, quality of life, and survival of cancer patients. Considering the tumor–host relationship as an integral and dynamic biological system, the chronic inflammation generated by the tumor is a communication mechanism among tissues and organs that is primarily orchestrated through different signals, such as cytokines, chemokines, growth factors, and exosomes, to provide the tumor with energetic components that allow it to continue proliferating. In this review, we aim to provide a succinct overview of the involvement of cancer-related inflammation at the local and systemic level throughout tumor development and the emergence of some paraneoplastic syndromes and their main clinical manifestations. In addition, the involvement of these signals throughout tumor development will be discussed based on the physiological/biological activities of innate and adaptive immune cells. These cellular interactions require a metabolic reprogramming program for the full activation of the various cells; thus, these requirements and the by-products released into the microenvironment will be considered. In addition, the systemic impact of cancer-related proinflammatory cytokines on the liver—as a critical organ that produces the leading inflammatory markers described to date—will be summarized. Finally, the contribution of cancer-related inflammation to the development of two paraneoplastic syndromes, myelopoiesis and cachexia, will be discussed.

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What defines a chemokine? – The curious case of CXCL17

Giblin

Pease

2023

Cytokine

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A comprehensive review of chemokine CXC17 (VCC1) in cancer, infection, and inflammation

Cited by 4 publications

References 60 publications

Prognosis and Dissection of the Immune Microenvironment in Head and Neck Squamous Cell Carcinoma Based on Fatty Acid Metabolism-Related Signatures

Prognosis and Dissection of the Immune Microenvironment in Head and Neck Squamous Cell Carcinoma Based on Fatty Acid Metabolism-Related Signatures

The systemic-level repercussions of cancer-associated inflammation mediators produced in the tumor microenvironment

What defines a chemokine? – The curious case of CXCL17

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