A Comprehensive Review of Bioactive Glass Coatings: State of the Art, Challenges and Future Perspectives

Sergi, Rachele; Bellucci, Devis; Cannillo, Valeria

doi:10.3390/coatings10080757

Cited by 70 publications

(49 citation statements)

References 197 publications

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“…Dependent on the type of material used, the resultant coatings can be divided into organic, inorganic, and composite [33]. Coatings on the surface of the implants may be formed using various technologies, including electrophoretic deposition, sol-gel technique, enameling, physical vapor deposition (pulsed lased deposition and pulsed electron deposition), and magnetron sputtering [34]. Another method that belongs to additive modifications of biomaterial surface is plasma technology [35].…”

Section: Additive Modifications Of Biomaterials Surfacementioning

confidence: 99%

“…There are two main classes of plasma-thermal and non-thermal plasmas [82]. Thermal spraying methods have been commonly applied to modify ceramic or metallic substrates [34]. Principal thermal plasma spraying techniques include: atmospheric plasma spraying, high velocity suspension flame spraying, suspension plasma spraying, solution precursors plasma spraying, flame spraying [19,34,83], and plasma electrolytic oxidation [84,85].…”

Section: Inorganic and Composite Coatingsmentioning

confidence: 99%

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Osteoconductive and Osteoinductive Surface Modifications of Biomaterials for Bone Regeneration: A Concise Review

Kazimierczak

Przekora

2020

Coatings

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The main aim of bone tissue engineering is to fabricate highly biocompatible, osteoconductive and/or osteoinductive biomaterials for tissue regeneration. Bone implants should support bone growth at the implantation site via promotion of osteoblast adhesion, proliferation, and formation of bone extracellular matrix. Moreover, a very desired feature of biomaterials for clinical applications is their osteoinductivity, which means the ability of the material to induce osteogenic differentiation of mesenchymal stem cells toward bone-building cells (osteoblasts). Nevertheless, the development of completely biocompatible biomaterials with appropriate physicochemical and mechanical properties poses a great challenge for the researchers. Thus, the current trend in the engineering of biomaterials focuses on the surface modifications to improve biological properties of bone implants. This review presents the most recent findings concerning surface modifications of biomaterials to improve their osteoconductivity and osteoinductivity. The article describes two types of surface modifications: (1) Additive and (2) subtractive, indicating biological effects of the resultant surfaces in vitro and/or in vivo. The review article summarizes known additive modifications, such as plasma treatment, magnetron sputtering, and preparation of inorganic, organic, and composite coatings on the implants. It also presents some common subtractive processes applied for surface modifications of the biomaterials (i.e., acid etching, sand blasting, grit blasting, sand-blasted large-grit acid etched (SLA), anodizing, and laser methods). In summary, the article is an excellent compendium on the surface modifications and development of advanced osteoconductive and/or osteoinductive coatings on biomaterials for bone regeneration.

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Section: Additive Modifications Of Biomaterials Surfacementioning

confidence: 99%

Section: Inorganic and Composite Coatingsmentioning

confidence: 99%

Osteoconductive and Osteoinductive Surface Modifications of Biomaterials for Bone Regeneration: A Concise Review

Kazimierczak

Przekora

2020

Coatings

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“…Its composition and mechanical properties are very similar to teeth and thus it is often used as a topical treatment for enamel wear (Vahid et al, 2012). In the case of contemporary orthopedic implants, including TKA and THA, bioglass and its derivative Novamin are commonly used as a coating for metallic bearings (Sergi et al, 2020), as opposed to a bulk material. Due to its similarities to bone, bioglass shows excellent biocompatibility.…”

Section: Novamin/bioglassmentioning

confidence: 99%

Mechanical Properties of Biomaterials Used in Total Hip and Knee Arthroplasty

Kenney¹,

Garner²

2021

Preprint

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Total hip and knee arthroplasty (THA and TKA) represent two of the most successful operations in orthopedics. For a total hip or knee prosthesis to function successfully, it must transfer mechanical loads up to seven times the individual's body weight from the axial skeleton to the lower extremities with minimal friction and wear. This is achieved by constructing prostheses from integrated components of different mechanical properties: a shock-absorbing and low-friction interface between the native joint and implant; a harder and stronger piece supporting the deformable interface, and an anchor securing the implant and transferring loads to the native bone.As early as the 1960s, polymers such as ultra-high molecular weight polyethylene (UHMWPE) were known to perform successfully at the joint-implant interface. Both ceramics and metals have historically been used for the main support of the implant, although metals and especially titanium alloys have taken preference in recent years. Recently, a flood of innovations has allowed material scientists to maximize the mechanical properties of these materials to increase mechanical strength, adjust elasticity, and improve biocompatibility. These innovations include the development of metal alloys and ceramic composites, reinforcement with carbon nanotubes and hydroxyapatite, antioxidant doping, gamma radiation-induced crosslinking, and bioactive coatings. Today, not only the mechanical properties but also the wear resistance and osseointegration of total hip and knee implants are far improved. This has led to better mechanical and physiological integration of the implants with the body and the necessary durability for younger patients' more active lifestyles. In this paper, these innovations will be explored within the framework of implant mechanics to provide a comparative assessment of current materials' mechanical capabilities, advantages, and disadvantages.

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“…The last decades witnessed an unprecedented demand for innovative bio-functional materials, capable of not only preventing failure, but also prolonging the life time of orthopaedic/dental implants and bone grafting scaffolds. Silica-based bioactive glasses (SBG) represent a group of reactive biomaterials that possess outstanding features (e.g., bioactivity, osteoproduction, angiogenesis), which are crucial for assuring an excellent interfacial bonding between the host bone tissue and implants [1][2][3][4][5][6][7]. The continuous effervescence in the SBG realm, associated with its unique physicalchemical and biological functional properties [2,5,7], is certified by a progressive yearly increase in the number of publications [5].…”

Section: Introductionmentioning

confidence: 99%

“…Over 30 years since its first implantation in 1985, 45S5 bioactive glass has been implanted into 1.5 million patients worldwide under various forms and trade names (e.g., Perioglas ® , NovaBone ® , Biogran ® , NovaMin ® , TeraSphere ® ) [2,5]. Due to their high indices of bioactivity, 45S5-based formulations have been proposed as coating materials for the bio-functionalisation of various metallic titanium-based implants [7,9], to enhance their bone-bonding ability. However, the disparity of the coefficients of thermal expansion (CTE) of 45S5 (i.e.,~14-17 × 10 −6 • C −1 ) and titanium-based (i.e.,~8.5-9.6 × 10 −6 • C −1 ) materials cannot be circumvented with ease [10], and represents a hazard for the long-term mechanical performance of the implant coating.…”

Section: Introductionmentioning

confidence: 99%

The Beneficial Mechanical and Biological Outcomes of Thin Copper-Gallium Doped Silica-Rich Bio-Active Glass Implant-Type Coatings

et al. 2020

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Silica-based bioactive glasses (SBG) hold great promise as bio-functional coatings of metallic endo-osseous implants, due to their osteoproductive potential, and, in the case of designed formulations, suitable mechanical properties and antibacterial efficacy. In the framework of this study, the FastOs®BG alkali-free SBG system (mol%: SiO2—38.49, CaO—36.07, P2O5—5.61, MgO—19.24, CaF2—0.59), with CuO (2 mol%) and Ga2O3 (3 mol%) antimicrobial agents, partially substituting in the parent system CaO and MgO, respectively, was used as source material for the fabrication of intentionally silica-enriched implant-type thin coatings (~600 nm) onto titanium (Ti) substrates by radio-frequency magnetron sputtering. The physico-chemical and mechanical characteristics, as well as the in vitro preliminary cytocompatibility and antibacterial performance of an alkali-free silica-rich bio-active glass coating designs was further explored. The films were smooth (RRMS < 1 nm) and hydrophilic (water contact angle of ~65°). The SBG coatings deposited from alkali-free copper-gallium co-doped FastOs®BG-derived exhibited improved wear performance, with the coatings eliciting a bonding strength value of ~53 MPa, Lc3 critical load value of ~4.9 N, hardness of ~6.1 GPa and an elastic modulus of ~127 GPa. The Cu and Ga co-doped SBG layers had excellent cytocompatibility, while reducing after 24 h the Staphylococcus aureus bacterial development with 4 orders of magnitude with respect to the control situations (i.e., nutritive broth and Ti substrate). Thereby, such SBG constructs could pave the road towards high-performance bio-functional coatings with excellent mechanical properties and enhanced biological features (e.g., by coupling cytocompatibility with antimicrobial properties), which are in great demand nowadays.

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A Comprehensive Review of Bioactive Glass Coatings: State of the Art, Challenges and Future Perspectives

Cited by 70 publications

References 197 publications

Osteoconductive and Osteoinductive Surface Modifications of Biomaterials for Bone Regeneration: A Concise Review

Osteoconductive and Osteoinductive Surface Modifications of Biomaterials for Bone Regeneration: A Concise Review

Mechanical Properties of Biomaterials Used in Total Hip and Knee Arthroplasty

The Beneficial Mechanical and Biological Outcomes of Thin Copper-Gallium Doped Silica-Rich Bio-Active Glass Implant-Type Coatings

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