A comprehensive mechanistic insight into the dietary and estrogenic lignans, arctigenin and sesamin as potential anticarcinogenic and anticancer agents. Current status, challenges, and future perspectives

Mottaghi, Sayeh; Abbaszadeh, Hassan

doi:10.1080/10408398.2021.1913568

Cited by 15 publications

(11 citation statements)

References 149 publications

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“…Steud. Its main pharmacological effects are inhibition of inflammation and anti-oxidative stress ( 364 , 365 ). Current research found that sesamin may inhibit oxidative stress and reduces cleaved-caspase-3 activation, lipid peroxidation and increases GSH activity.…”

Section: Modulatory Effects Of Natural Botanical Components On Microg...mentioning

confidence: 99%

The mechanism of microglia-mediated immune inflammation in ischemic stroke and the role of natural botanical components in regulating microglia: A review

et al. 2023

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Ischemic stroke (IS) is one of the most fatal diseases. Neuroimmunity, inflammation, and oxidative stress play important roles in various complex mechanisms of IS. In particular, the early proinflammatory response resulting from the overactivation of resident microglia and the infiltration of circulating monocytes and macrophages in the brain after cerebral ischemia leads to secondary brain injury. Microglia are innate immune cells in the brain that constantly monitor the brain microenvironment under normal conditions. Once ischemia occurs, microglia are activated to produce dual effects of neurotoxicity and neuroprotection, and the balance of the two effects determines the fate of damaged neurons. The activation of microglia is defined as the classical activation (M1 type) or alternative activation (M2 type). M1 type microglia secrete pro-inflammatory cytokines and neurotoxic mediators to exacerbate neuronal damage, while M2 type microglia promote a repairing anti-inflammatory response. Fine regulation of M1/M2 microglial activation to minimize damage and maximize protection has important therapeutic value. This review focuses on the interaction between M1/M2 microglia and other immune cells involved in the regulation of IS phenotypic characteristics, and the mechanism of natural plant components regulating microglia after IS, providing novel candidate drugs for regulating microglial balance and IS drug development.

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Section: Modulatory Effects Of Natural Botanical Components On Microg...mentioning

confidence: 99%

The mechanism of microglia-mediated immune inflammation in ischemic stroke and the role of natural botanical components in regulating microglia: A review

et al. 2023

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“…Many studies demonstrated that natural lignans possess great anti-tumor activities against a variety of human cancer cell lines by inhibiting all phases of carcinogenesis, including initiation, promotion and progression and by modulating different signaling pathways involved in cell proliferation and death control [ 148 ]. Dietary lignan secoisolariciresinol diglucoside can mainly induce the intrinsic apoptotic mechanism by targeting several molecules.…”

Section: Polyphenol-mediated Apoptosis As Anticancer Mechanismmentioning

confidence: 99%

The Involvement of Natural Polyphenols in Molecular Mechanisms Inducing Apoptosis in Tumor Cells: A Promising Adjuvant in Cancer Therapy

Chimento

Luca

D’Amico

et al. 2023

IJMS

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Various literature data show how a diet rich in vegetables could reduce the incidence of several cancers due to the contribution of the natural polyphenols contained in them. Polyphenols are attributed multiple pharmacological actions such as anti-inflammatory, anti-oxidant, antibiotic, antiseptic, anti-allergic, cardioprotective and even anti-tumor properties. The multiple mechanisms involved in their anti-tumor action include signaling pathways modulation associated with cell proliferation, differentiation, migration, angiogenesis, metastasis and cell death. Since the dysregulation of death processes is involved in cancer etiopathology, the natural compounds able to kill cancer cells could be used as new anticancer agents. Apoptosis, a programmed form of cell death, is the most potent defense against cancer and the main mechanism used by both chemotherapy agents and polyphenols. The aim of this review is to provide an update of literature data on the apoptotic molecular mechanisms induced by some representative polyphenol family members in cancer cells. This aspect is particularly important because it may be useful in the design of new therapeutic strategies against cancer involving the polyphenols as adjuvants.

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“…3) [45]. In general, the roots, buds, and seeds of A. lappa have widely been employed in traditional medicine for treatment of hepatitis, hypertension, gout, and inflammatory diseases, also serving as a blood purifier, and they have been used as a remedy for rheumatism, scurvy, venereal disease, and sores, with the leaves being used for the healing of wounds, burns, and gastric ulcers [46][47][48]. Since the roots are traditionally used to treat diseases such as sore throat and infections such as rashes, boils and various skin problems, the seed and fruits are also used for skin conditions, as well as in cold/flu formulae [49].…”

Section: Taxonomy Botanical and Ethnopharmacological Aspectsmentioning

confidence: 99%

Arctium lappa (Burdock): Insights from ethnopharmacology potential, chemical constituents, clinical studies, pharmacological utility and nanomedicine

Yosri

Alsharif

Xiao

et al. 2023

Biomedicine & Pharmacotherapy

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A comprehensive mechanistic insight into the dietary and estrogenic lignans, arctigenin and sesamin as potential anticarcinogenic and anticancer agents. Current status, challenges, and future perspectives

Cited by 15 publications

References 149 publications

The mechanism of microglia-mediated immune inflammation in ischemic stroke and the role of natural botanical components in regulating microglia: A review

The mechanism of microglia-mediated immune inflammation in ischemic stroke and the role of natural botanical components in regulating microglia: A review

The Involvement of Natural Polyphenols in Molecular Mechanisms Inducing Apoptosis in Tumor Cells: A Promising Adjuvant in Cancer Therapy

Arctium lappa (Burdock): Insights from ethnopharmacology potential, chemical constituents, clinical studies, pharmacological utility and nanomedicine

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