The Involvement of Natural Polyphenols in Molecular Mechanisms Inducing Apoptosis in Tumor Cells: A Promising Adjuvant in Cancer Therapy

Chimento, Adele; Luca, Arianna De; D’Amico, Maria; Amicis, Francesca De; Pezzi, Vincenzo

doi:10.3390/ijms24021680

Cited by 24 publications

(15 citation statements)

References 195 publications

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“…Further, genistein/or daidzein is only one of the polyphenols consumed in the diet. The combined concentration, bioavailability, and action of polyphenols, such as flavonoids, tannins, etc., may be greater than those of dietary isoflavone alone, as all polyphenols are active prooxidants [ 26 , 59 , 60 , 61 , 62 ]. Nonetheless, it is important to note that different dietary polyphenols have a relatively limited half-life in vivo since they are rapidly digested [ 60 , 61 , 62 ].…”

Section: Discussionmentioning

confidence: 99%

“…The combined concentration, bioavailability, and action of polyphenols, such as flavonoids, tannins, etc., may be greater than those of dietary isoflavone alone, as all polyphenols are active prooxidants [ 26 , 59 , 60 , 61 , 62 ]. Nonetheless, it is important to note that different dietary polyphenols have a relatively limited half-life in vivo since they are rapidly digested [ 60 , 61 , 62 ]. For this reason, it is possible that plant polyphenols are not as effective as anticancer medications already in use in clinical settings.…”

Section: Discussionmentioning

confidence: 99%

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Soy Isoflavones Induce Cell Death by Copper-Mediated Mechanism: Understanding Its Anticancer Properties

et al. 2023

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Cancer incidence varies around the globe, implying a relationship between food and cancer risk. Plant polyphenols are a class of secondary metabolites that have recently attracted attention as possible anticancer agents. The subclass of polyphenols, known as isoflavones, includes genistein and daidzein, which are present in soybeans and are regarded as potent chemopreventive agents. According to epidemiological studies, those who eat soy have a lower risk of developing certain cancers. Several mechanisms for the anticancer effects of isoflavones have been proposed, but none are conclusive. We show that isoflavones suppress prostate cancer cell growth by mobilizing endogenous copper. The copper-specific chelator neocuproine decreases the apoptotic potential of isoflavones, whereas the iron and zinc chelators desferroxamine mesylate and histidine do not, confirming the role of copper. Reactive oxygen species (ROS) scavengers reduce isoflavone-induced apoptosis in these cells, implying that ROS are cell death effectors. Our research also clearly shows that isoflavones interfere with the expression of the two copper transporter genes, CTR1 and ATP7A, in cancerous cells. Copper levels are widely known to be significantly raised in all malignancies, and we confirm that isoflavones can target endogenous copper, causing prooxidant signaling and, eventually, cell death. These results highlight the importance of copper dynamics within cancer cells and provide new insight into the potential of isoflavones as cancer-fighting nutraceuticals.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Soy Isoflavones Induce Cell Death by Copper-Mediated Mechanism: Understanding Its Anticancer Properties

et al. 2023

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“…25,26,60 In accordance to epidemiologic evidence, a food intake having a high content of fruits and vegetables could minimize the probability of occurrence of specific cancers. 61 Natural polyphenols have implicated potential anticancer or antitumor activity due to various biological mechanisms associated with different signaling pathways such as cell propagation, differentiation, relocation, angiogenesis, metastasis, and cellular death (Figure 3). These phytocompounds have shown the capability to specifically inhibit the growth or kill carcinogenic cells due to dysregulation of death processes that are typically associated with cancer etiopathology and thus can be used as potential chemotherapeutic agents.…”

Section: Classification Of Various Polyphenols and Their Role In Canc...mentioning

confidence: 99%

Therapeutic Implications of Dietary Polyphenols-Loaded Nanoemulsions in Cancer Therapy

Tomar,

Das,

Balaga

et al. 2024

ACS Appl. Bio Mater.

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Cancer is one of the major causes of death worldwide, even the second foremost cause related to non-communicable diseases. Cancer cells typically possess several cellular and biological processes including, persistence, propagation, differentiation, cellular death, and expression of cellular-type specific functions. The molecular picture of carcinogenesis and progression is unwinding, and it appears to be a tangled combination of processes occurring within and between cancer cells and their surrounding tissue matrix. Polyphenols are plant secondary metabolites abundant in fruits, vegetables, cereals, and other natural plant sources. Natural polyphenols have implicated potential anticancer activity by various mechanisms involved in their antitumor action, including modulation of signaling pathways majorly related to cellular proliferation, differentiation, relocation, angiogenesis, metastatic processes, and cell death. The applications of polyphenols have been limited due to the hydrophobic nature and lower oral bioavailability that could be possibly overcome through encapsulating them into nanocarrier-mediated delivery systems, leading to improved anticancer activity. Nanoemulsions (NEs) possess diverse feasible properties, including greater surface area, modifiable surficial charge, higher half-life, site-specific targeting, and formulation imaging capability necessary to create a practical therapeutic impact, and have drawn increased attention in cancer therapy research. This review has summarized and discussed the basic concepts, classification, delivery approaches, and anticancer mechanism of various polyphenols and polyphenols-encapsulated nanoemulsions with improved cancer therapy.

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“…6 Among a variety of compounds that present considerable antioxidant activity, phenolic entities, more precisely, polyphenols, are a class of molecules that has been heavily studied over the years. 7−11 Beyond their antioxidant potential, these chemical species are known for presenting desired health-related properties such as anti-inflammatory, 12 antiviral, 13 antidiabetic, 14 and antitumor actions 15 and, thus, there is a continuously increasing interest in searching for new polyphenolic species either through isolation/identification of naturally occurring species or via structural modification through synthesis. 16−19 In the latter case, the use of computational-based protocols may provide useful insights and contribute to optimizing the strategies for performing specific modifications in polyphenol structures aiming to yield compounds with enhanced properties.…”

Section: ■ Introductionmentioning

confidence: 99%

Probing Antioxidant-Related Properties for Phenolic Compounds

Soares,

Peterson,

de Souza

2024

J. Phys. Chem. A

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In this work, properties related to antioxidant-potential mechanisms (such as the bond dissociation enthalpy, BDE, for the homolytic cleavage of the O−H bond and ionization energies, IEs) were determined for phenol, pyrocatechol, and gallic acid (GA). Both the protonated and deprotonated forms of GA were investigated. The Feller−Peterson−Dixon (FPD) composite method was employed with a variety of computational approaches, i.e., density functional theory, Moller− Plesset perturbation theory, and coupled-cluster-based methods, in combination with large correlation consistent basis sets with extrapolation to the complete basis set limit and consideration of core electron correlation effects. FPD results were compared to experimental and computational data available in the literature, presenting good agreement. For example, the FPD BDE (298 K) obtained for phenol, which was based on valence-correlated MP2/CBS calculations with contributions from correlating all electrons, was determined to be 87.56 kcal/mol, a value that is 0.42 kcal/mol lower than the result obtained in the most recent experiments, 87.98 ± 0.62. Calibration against coupled-cluster calculations was also carried out for phenol. We expect that the outcomes gathered here may help in establishing a general protocol for computational chemists that are interested in determining antioxidant-related properties for phenolic compounds with considerable accuracy as well as to motivate future IE measurements (particularly for GA) to be accomplished in the near future.

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The Involvement of Natural Polyphenols in Molecular Mechanisms Inducing Apoptosis in Tumor Cells: A Promising Adjuvant in Cancer Therapy

Cited by 24 publications

References 195 publications

Soy Isoflavones Induce Cell Death by Copper-Mediated Mechanism: Understanding Its Anticancer Properties

Soy Isoflavones Induce Cell Death by Copper-Mediated Mechanism: Understanding Its Anticancer Properties

Therapeutic Implications of Dietary Polyphenols-Loaded Nanoemulsions in Cancer Therapy

Probing Antioxidant-Related Properties for Phenolic Compounds

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