A Comprehensive Evaluation of Solid Tumor Analysis in the Clinical Space

Kelly, Kevin; Ras, Aleksandra; Helm, Samantha

doi:10.4172/2469-9853.1000129

Cited by 2 publications

(1 citation statement)

References 21 publications

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“…Each of these conventional treatment choices works to focus on the molecular "side effects" of tumor development as opposed to the reason. Regrettably, the cellular death affected by these medicines isn't constrained to malignant growth cells (Kelly et al 2016). Hence, the alternative and complementary medicines and the application of functional foods or medicinal herbs may be an alternative gateway to combat the cancer progression (Yin et al 2013).…”

Section: Introductionmentioning

confidence: 99%

Efficacy of ginsenoside Rg3 nanoparticles against Ehrlich solid tumor growth in mice

El-Banna

Hendawy

El‐Nekeety

et al. 2022

Environ Sci Pollut Res

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Solid tumors are fairly common and face many clinical di culties since they are hardly surgically resectable and broadly do not respond to radiation and chemotherapy. The current study aimed to fabricate ginsenoside Rg3 nanoparticles (Rg3-NPs) and evaluate their antitumor effect against Ehrlich solid tumors (EST) in mice. Rg3-NPs were fabricated using whey protein isolates (WPI), maltodextrin (MD), and gum Arabic (GA). EST was developed by the injection of mice with Ehrlich ascites cells (2.5 x 10 6 ). The mice were divided into a control group, EST group, and the EST groups that were treated orally 2 weeks for with normal Rg3 (3 mg/kg b.w), Rg3-NPs at a low dose (3 mg/kg b.w), and Rg3-NPs at a high dose (6 mg/kg b.w). Serum and solid tumors were collected for different assays. The results revealed that synthesized Rg3-NPs showed a spherical shape with an average particle size of 20 nm and zeta potential of -5.58 mV. The in vivo study revealed that EST mice showed a signi cant increase in AFP, Casp3, TNF-α, MMP-9, VEGF, MDA DNA damage accompanied by a signi cant decrease in SOD and GPx. Treatment with Rg3 or Rg3-NPs decreased the tumor weight and size and induced a signi cant improvement in all the biochemical parameters. Rg3-NPs were more effective than Rg3 and the improvement was dosedependent. It could be concluded that fabrication of Rg3-NPs enhanced the protective effect against EST development which may be due to the synergistic effect of Rg3 and MD, GA, and WPI. Plant materials and Preparation of ginsenoside Rg3 nanoparticles (Rg3-NPs)Phoenix ginseng (the standardized Panax ginseng extract) containing 3.6% ginsenoside Rg3 (Rg3) was supplied by LOTTE Group R & D Center (Seoul, Korea). MD, GA, and WPI (1:1:1 w/w) were dissolved in 800 ml of distilled water with stirring. Solutions were left overnight at room temperature before emulsi cation for full hydration. Rg3 was dissolved in deionized water (10 g/100 ml) and the solution was progressively added to the polymer solution with homogenization at 20000 rpm for 10 min. The concentration of polymer was 20%, and Rg3 was 10% of the polymer mass concentration. The emulsion was encapsulated using a spray drier (B-290, Buchi) equipped with a pressure air atomizing nozzle at 2.5 bar, inlet, and outlet temperatures were 160 ± 5 and 85 ± 5 o C, respectively. The dried Rg3-NPs powder was collected and stored at 4 o C until analysis (Jinapong et al. 2008).

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Section: Introductionmentioning

confidence: 99%

Efficacy of ginsenoside Rg3 nanoparticles against Ehrlich solid tumor growth in mice

El-Banna

Hendawy

El‐Nekeety

et al. 2022

Environ Sci Pollut Res

View full text Add to dashboard Cite

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Efficacy of Ginsenoside Rg3 Nanoparticles Against Ehrlich Solid Tumor Growth in Mice

El-Banna

Hendawy

El‐Nekeety

et al. 2021

Preprint

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Solid tumors are fairly common and face many clinical difficulties since they are hardly surgically resectable and broadly do not respond to radiation and chemotherapy. The current study aimed to fabricate ginsenoside Rg3 nanoparticles (Rg3-NPs) and evaluate their antitumor effect against Ehrlich solid tumors (EST) in mice. Rg3-NPs were fabricated using whey protein isolates (WPI), maltodextrin (MD), and gum Arabic (GA). EST was developed by the injection of mice with Ehrlich ascites cells (2.5 x 106). The mice were divided into a control group, EST group, and the EST groups that were treated orally 2 weeks for with normal Rg3 (3 mg/kg b.w), Rg3-NPs at a low dose (3 mg/kg b.w), and Rg3-NPs at a high dose (6 mg/kg b.w). Serum and solid tumors were collected for different assays. The results revealed that synthesized Rg3-NPs showed a spherical shape with an average particle size of 20 nm and zeta potential of -5.58 mV. The in vivo study revealed that EST mice showed a significant increase in AFP, Casp3, TNF-α, MMP-9, VEGF, MDA DNA damage accompanied by a significant decrease in SOD and GPx. Treatment with Rg3 or Rg3-NPs decreased the tumor weight and size and induced a significant improvement in all the biochemical parameters. Rg3-NPs were more effective than Rg3 and the improvement was dose-dependent. It could be concluded that fabrication of Rg3-NPs enhanced the protective effect against EST development which may be due to the synergistic effect of Rg3 and MD, GA, and WPI.

show abstract

A Comprehensive Evaluation of Solid Tumor Analysis in the Clinical Space

Cited by 2 publications

References 21 publications

Efficacy of ginsenoside Rg3 nanoparticles against Ehrlich solid tumor growth in mice

Efficacy of ginsenoside Rg3 nanoparticles against Ehrlich solid tumor growth in mice

Efficacy of Ginsenoside Rg3 Nanoparticles Against Ehrlich Solid Tumor Growth in Mice

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