A complete route for biodegradation of potentially carcinogenic cyanotoxin microcystin-LR in a novel indigenous bacterium

Yang, Fei; Huang, Feiyu; Feng, Hai; Jia, Wei; Massey, Isaac Yaw; Liang, Geyu; Zhang, Fang; Yin, Lihong; Kacew, Sam; Zhang, Xian; Pu, Yuepu

doi:10.1016/j.watres.2020.115638

Cited by 117 publications

(78 citation statements)

References 67 publications

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“…Further Stenotrophomonas maltophilia 4B4 showed total MC-LR removed within 10 days while MC-RR and MC-LF elimination occurred within 12 and 14 days respectively [16]. In a recent publication, a novel bacteria strain YF1 of the genus Sphingopyxis indicated thorough MC-LR degradation within 120 min [123]. The evidence thus indicates that bacteria strains isolated from many different environmental habitats around the world have strong MC-degrading ability, and may play a significant role in the natural degradation and removal of MCs.…”

Section: Biological Degradation By Bacteriamentioning

confidence: 97%

“…Subsequently PAA-CoA was degraded to acetyl coenzyme A (acetyl-CoA) by PaaA, PaaG and PaaZ homologues. Finally, acetyl-CoA was completely converted to CO 2 through tricarboxylic acid (TCA) cycle [123]. The evidence suggests that PAA may be the downstream metabolism path of MC degradation.…”

Section: Enzymatic Mechanisms Of Microcystins Biodegradationmentioning

confidence: 98%

“…These findings also suggest that more than three intermediate products are capable to occur during MC degradation. In a recent study Yang et al [123] found a potential link between paa gene clusters for phenylacetic acid (PAA) degradation in the neighborhoods of mlrABCD gene cluster. Interestingly complete MC-LR degradation by Sphingopyxis sp.…”

Section: Enzymatic Mechanisms Of Microcystins Biodegradationmentioning

confidence: 99%

“…Biodegradation pathway of MC-LR by Sphingopyxis sp. YF1 (reproduced from[123], 2020, Elsevier Ltd.).…”

mentioning

confidence: 99%

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A Mini Review on Microcystins and Bacterial Degradation

Massey

Yang

2020

Toxins

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Microcystins (MCs) classified as hepatotoxic and carcinogenic are the most commonly reported cyanobacterial toxins found in the environment. Microcystis sp. possessing a series of MC synthesis genes (mcyA-mcyJ) are well documented for their excessive abundance, numerous bloom occurrences and MC producing capacity. About 246 variants of MC which exert severe animal and human health hazards through the inhibition of protein phosphatases (PP1 and PP2A) have been characterized. To minimize and prevent MC health consequences, the World Health Organization proposed 1 µg/L MC guidelines for safe drinking water quality. Further the utilization of bacteria that represent a promising biological treatment approach to degrade and remove MC from water bodies without harming the environment has gained global attention. Thus the present review described toxic effects and bacterial degradation of MCs.

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Section: Biological Degradation By Bacteriamentioning

confidence: 97%

Section: Enzymatic Mechanisms Of Microcystins Biodegradationmentioning

confidence: 98%

Section: Enzymatic Mechanisms Of Microcystins Biodegradationmentioning

confidence: 99%

“…Biodegradation pathway of MC-LR by Sphingopyxis sp. YF1 (reproduced from[123], 2020, Elsevier Ltd.).…”

mentioning

confidence: 99%

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A Mini Review on Microcystins and Bacterial Degradation

Massey

Yang

2020

Toxins

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“…The cyclic heptapeptide hepatotoxins are relatively stable in natural environments and resistant to chemical and physical factors including extreme temperatures, pH changes, sunlight and degradation via non-specific enzymes owing to their cyclic structure [ 6 , 7 , 8 ]. The common structure of MCs is cyclo-(-D-Ala-L-X-DisoMeAsp-L-Z-Adda-D-isoGlu-Mdha), where X and Z are highly variable amino acids, D-MeAsp is D-erythro-b-methylaspartic acid, Mdha is N-methyldehydroalanine, and Adda is (2S, 3S, 8S, 9S)3-amino-9 methoxy-2,6,8-trimethyl-10-phenyldeca-4, 6-dienoic acid [ 9 , 10 , 11 ]. More than 270 MC variants have been isolated from CyanoHABs [ 12 ].…”

Section: Introductionmentioning

confidence: 99%

A Mini-Review on Detection Methods of Microcystins

Massey

Jia

et al. 2020

Toxins

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Cyanobacterial harmful algal blooms (CyanoHABs) produce microcystins (MCs) which are associated with animal and human hepatotoxicity. Over 270 variants of MC exist. MCs have been continually studied due of their toxic consequences. Monitoring water quality to assess the presence of MCs is of utmost importance although it is often difficult because CyanoHABs may generate multiple MC variants, and their low concentration in water. To effectively manage and control these toxins and prevent their health risks, sensitive, fast, and reliable methods capable of detecting MCs are required. This paper aims to review the three main analytical methods used to detect MCs ranging from biological (mouse bioassay), biochemical (protein phosphatase inhibition assay and enzyme linked immunosorbent assay), and chemical (high performance liquid chromatography, liquid chromatography-mass spectrometry, high performance capillary electrophoresis, and gas chromatography), as well as the newly emerging biosensor methods. In addition, the current state of these methods regarding their novel development and usage, as well as merits and limitations are presented. Finally, this paper also provides recommendations and future research directions towards method application and improvement.

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Synergistic microcystin degradation by a novel bacterium isolated from shrimp pond and fulvic acids

Qin,

Dai,

et al. 2024

J. Ocean. Limnol.

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A complete route for biodegradation of potentially carcinogenic cyanotoxin microcystin-LR in a novel indigenous bacterium

Cited by 117 publications

References 67 publications

A Mini Review on Microcystins and Bacterial Degradation

A Mini Review on Microcystins and Bacterial Degradation

A Mini-Review on Detection Methods of Microcystins

Synergistic microcystin degradation by a novel bacterium isolated from shrimp pond and fulvic acids

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