A comparison of two laser-based methods for determination of burn scar perfusion: Laser Doppler versus laser speckle imaging

Stewart, Catherine J.; Frank, Ryan C.; Forrester, Kevin; Tulip, J.; Lindsay, Robert; Bray, Robert C.

doi:10.1016/j.burns.2005.04.004

Cited by 148 publications

(112 citation statements)

References 39 publications

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“…36 This correlation is still acceptable when data are represented as a percentage increase from baseline (for local heating at 36°C, 39°C, 42°C, and 44°C on the forearm of healthy subjects) but decreases when the biological zero value is subtracted. 36 Moreover, Stewart et al 41 reported a very good correlation between LSCI and LDPI in burn scar perfusion assessment in vivo.…”

Section: Correlation Between Lsci and Ldpimentioning

confidence: 99%

Assessment of Skin Microvascular Function and Dysfunction With Laser Speckle Contrast Imaging

Mahé

Humeau-Heurtier

Durand

et al. 2012

Circ: Cardiovascular Imaging

133

115

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Section: Correlation Between Lsci and Ldpimentioning

confidence: 99%

Assessment of Skin Microvascular Function and Dysfunction With Laser Speckle Contrast Imaging

Mahé

Humeau-Heurtier

Durand

et al. 2012

Circ: Cardiovascular Imaging

133

115

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“…Laser Doppler flowmetry is commonly used to provide a surrogate measure of cutaneous blood flow by measuring red blood cell movement, or flux. This technique provides reproducible dynamic measures of change in red blood cell flux (12), whilst higher spatial resolution variants on this approach include laser Doppler perfusion imaging (37,39) and laser speckle perfusion imaging (5), both of which provide a two dimensional map of blood perfusion, often color-coded to provide a graphical indication of areas of flow. These techniques are all limited in that i) they do not provide direct visualization of the microvascular diameter and outputs therefore reflect, but are not direct indices of, blood flow, and ii) their depth of measurement is unknown.…”

Section: Introductionmentioning

confidence: 99%

Optical coherence tomography in the assessment of acute changes in cutaneous vascular diameter induced by heat stress

Carter

Gong

Kirk

et al. 2016

Journal of Applied Physiology

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Optical coherence tomography in the assessment of acute changes in cutaneous vascular diameter induced by heat stress.http://researchonline.ljmu.ac.uk/4156/ Article LJMU has developed LJMU Research Online for users to access the research output of the University more effectively. Copyright © and Moral Rights for the papers on this site are retained by the individual authors and/or other copyright owners. Users may download and/or print one copy of any article(s) in LJMU Research Online to facilitate their private study or for non-commercial research. You may not engage in further distribution of the material or use it for any profit-making activities or any commercial gain.The version presented here may differ from the published version or from the version of the record. Please see the repository URL above for details on accessing the published version and note that access may require a subscription. AbstractThere are limited imaging technologies available that can accurately assess or provide surrogate markers of the in vivo cutaneous microvessel network in humans. In this study, we establish the use of optical coherence tomography (OCT) as a novel imaging technique to assess acute changes in cutaneous microvessel area density and diameter in humans. OCT speckle decorrelation images of the skin on the ventral side of the forearm up to a depth of 500 μm were obtained prior to and following 20-25 mins of lower limb heating in eight healthy males (30.3±7.6 yrs). Skin red blood cell flux was also collected using laser Doppler flowmetry probes immediately adjacent to the OCT skin sites, along with skin temperature.OCT speckle decorrelation images were obtained at both baseline and heating time points. New & NoteworthyThis manuscript examines for the first time the utility of optical coherence tomography (OCT) as a novel imaging technique to visualize and quantify changes in the cutaneous microvasculature in response to acute passive heating. We hypothesized that lower body heating would induce detectible microvascular changes in the skin of the forearm. Our findings demonstrate the capacity of OCT to image vascular structures over multiple time points, and to quantify these changes using automated techniques.

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“…LDI is considered to be a valid measure of burn depth and exhibits high correlation with burn wound histology; yet, current commercially-available laser Doppler imagers are relatively large, require a prolong scanning time, and are not promoted for early diagnosis during the first 48 hours postburn (hpb) [4,7,8]. Laser speckle contrast analysis (LASCA) is another optical technique, related to LDI, which has been used for noninvasive scan-free assessment of burn severity [4,[9][10][11]. In LASCA, a wide-area laser beam illuminates the burn wound to produce speckle from backscatter off the irradiated tissue volume.…”

Section: Introductionmentioning

confidence: 99%

In vivo burn diagnosis by camera-phone diffuse reflectance laser speckle detection

Ragol¹,

Remer²,

Shoham³

et al. 2015

Biomed. Opt. Express

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Burn diagnosis using laser speckle light typically employs widefield illumination of the burn region to produce two-dimensional speckle patterns from light backscattered from the entire irradiated tissue volume. Analysis of speckle contrast in these time-integrated patterns can then provide information on burn severity. Here, by contrast, we use point illumination to generate diffuse reflectance laser speckle patterns of the burn. By examining spatiotemporal fluctuations in these time-integrated patterns along the radial direction from the incident point beam, we show the ability to distinguish partial-thickness burns in a porcine model in vivo within the first 24 hours post-burn. Furthermore, our findings suggest that time-integrated diffuse reflectance laser speckle can be useful for monitoring burn healing over time post-burn. Unlike conventional diffuse reflectance laser speckle detection systems that utilize scientific or industrial-grade cameras, our system is designed with a camera-phone, demonstrating the potential for burn diagnosis with a simple imager.

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A comparison of two laser-based methods for determination of burn scar perfusion: Laser Doppler versus laser speckle imaging

Cited by 148 publications

References 39 publications

Assessment of Skin Microvascular Function and Dysfunction With Laser Speckle Contrast Imaging

Assessment of Skin Microvascular Function and Dysfunction With Laser Speckle Contrast Imaging

Optical coherence tomography in the assessment of acute changes in cutaneous vascular diameter induced by heat stress

In vivo burn diagnosis by camera-phone diffuse reflectance laser speckle detection

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