A comparison of the toxicity of some allyl, propenyl, and propyl compounds in the rat

Taylor, Jean M.; Jenner, P; Jones, William I.

doi:10.1016/s0041-008x(64)80002-8

Cited by 129 publications

(27 citation statements)

References 2 publications

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“…As for eugenol, its acute toxicity is low when administered orally, with LD 50 values ranging from 1,930 to 2,680 mg kg -1 day -1 in rats (34,35). Its sub-chronic toxicity is also low, with no observed adverse effect level (NOAEL) ranging from 900->2,000 mg kg -1 day -1 .…”

Section: Food Consumption and Average Intake Datamentioning

confidence: 99%

Neuroprotective effects of eugenol against aluminiuminduced toxicity in the rat brain

Said

Rabo

2017

Archives of Industrial Hygiene and Toxicology

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Aluminium (Al) is a neurotoxic metal that contributes to the progression of several neurodegenerative diseases. The aim of the present study was to evaluate the protective effect of dietary eugenol supplementation against aluminium (Al)- induced cerebral damage in rats. Male Wistar rats were divided into four groups: normal controls, rats fed a diet containing 6,000 μg g-1 eugenol, rats intoxicated daily with aluminium chloride (84 mg kg-1 body weight) p. o. and fed either a basal diet or a eugenol-containing diet. Daily oral administration of Al for four consecutive weeks to rats significantly reduced brain total antioxidant status (TAS) (11.42±0.31 μmol g-1 tissue, p<0.001) with a subsequent significant enhancement of lipid peroxidation (MDA) (32.55±1.68 nmol g-1 tissue, p<0.002). In addition, Al enhanced brain acetylcholinesterase activity (AChE) (46.22±4.90 U mg-1 protein, p<0.001), tumour necrosis factor alpha (TNF-α) (118.72±11.32 pg mg-1 protein, p<0.001), and caspase 3 (Casp-3) (8.77±1.26 ng mg-1 protein, p<0.001) levels, and in contrast significantly suppressed brain-derived neurotrophic factor (BDNF) (82.74±14.53 pg mg-1 protein, p<0.002) and serotonin (5-HT) (1.54±0.12 ng mg-1 tissue, p<0.01) levels. Furthermore, decreased glial fibrillary acidic protein (GFAP) immunostaining was noticed in the striatum of Al-intoxicated rats, compared with untreated controls. On the other hand, co-administration of dietary eugenol with Al intoxication restored brain BDNF (108.76±2.64 pg mg-1 protein) and 5-HT (2.13±0.27 ng mg-1 tissue) to normal levels, enhanced brain TAS (13.43±0.24 μmol g-1 tissue, p<0.05), with a concomitant significant reduction in TNF-α (69.98±4.74 pg mg-1 protein) and Casp-3 (3.80±0.37 ng mg-1 protein) levels (p<0.001), as well as AChE activity (24.50±3.25 U mg-1 protein, p<0.001), and increased striatal GFAP immunoreactivity, compared with Al-treated rats. Histological findings of brain tissues verified biochemical data. In conclusion, eugenol holds potential as a neuroprotective agent through its hydrophobic, antioxidant, and anti-apoptotic properties, as well as its neurotrophic ability against Al-induced brain toxicity in rats.

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Section: Food Consumption and Average Intake Datamentioning

confidence: 99%

Neuroprotective effects of eugenol against aluminiuminduced toxicity in the rat brain

Said

Rabo

2017

Archives of Industrial Hygiene and Toxicology

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“…In addition, five clinical isolates (1)(2)(3)(4)(5) were used to test the activity during bioassay-guided purification, as some of the purified fractions were not available in sufficient amount to be tested on a larger number of isolates. The activity of the characterised active fraction (H12c) was tested on 14 other isolates (6)(7)(8)(9)(10)(11)(12)(13)(14)(15)(16)(17)(18)(19). Thus, a total of 19 clinical isolates (1)(2)(3)(4)(5)(6)(7)(8)(9)(10)(11)(12)(13)(14)(15)(16)(17)(18)(19) were used in this study, which were isolated from patients with acute gonococcal urethritis and were identified using standard methods [4,5].…”

Section: Neisseria Gonorrhoeae Clinical Isolates and World Health Orgmentioning

confidence: 99%

In vitro activity of eugenol, an active component from Ocimum sanctum, against multiresistant and susceptible strains of Neisseria gonorrhoeae

Shokeen¹,

Bala²,

Singh³

et al. 2008

International Journal of Antimicrobial Agents

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“…These values indicate that the acute toxicity of methoxy-and methylenedioxy-substituted allylbenzenes after oral intake is low Taylor et al, 1964;Hagan et al, 1965;Bär & Griepentrog, 1967;Keating, 1972;Moreno, 1972;Beroza et al, 1975). chemistry changes were reported in females.…”

Section: Acute Toxicitymentioning

confidence: 86%

“…Clinical chemistry evaluation revealed increased serum phosphate and AST in the highdose males and increased mean serum creatinine in all treated males. No significant Jenner et al (1964) 1789 Estragole Rat; M, F 1820 Jenner et al (1964) 1789 Estragole Rat; M, F 1820 Taylor et al (1964) 1789 Estragole Rat; M 1230 Moreno (1972) 1790 Methyl eugenol Rat; M, F 1560 Jenner et al (1964) 1790 Methyl eugenol Rat; NR 810 Keating (1972) 1790 Methyl eugenol Rat; NR 1560 Bär & Griepentrog (1967) 1790 Methyl eugenol Rat; M, F 1179 Beroza et al (1975) 1792 Safrole Mouse; NR 2350 Jenner et al (1964) 1792 Safrole Rat; M, F 1950M, F Jenner et al (1964 1792 Safrole Rat; NR 1950 Bär & Griepentrog (1967) 1792 Safrole Mouse; M, F 2350 Hagan et al (1965) 1792 Safrole Rat; M, F 1950 Hagan et al (1965) F, female; M, male; NR, not reported. Lipsky et al (1981aLipsky et al ( , 1981bLipsky et al ( , 1981c …”

Section: Short-term Studies Of Toxicitymentioning

confidence: 97%

Joint FAO/WHO Expert Committee on Food Additives (JECFA)

Sagert¹

2008

Encyclopedia of Global Health

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A comparison of the toxicity of some allyl, propenyl, and propyl compounds in the rat

Cited by 129 publications

References 2 publications

Neuroprotective effects of eugenol against aluminiuminduced toxicity in the rat brain

Neuroprotective effects of eugenol against aluminiuminduced toxicity in the rat brain

In vitro activity of eugenol, an active component from Ocimum sanctum, against multiresistant and susceptible strains of Neisseria gonorrhoeae

Joint FAO/WHO Expert Committee on Food Additives (JECFA)

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