A comparison of the geometric configurations adopted by radiation-induced chromatid interchanges in animals and plants

Wigglesworth, D.J.; Savage, John R. K.

doi:10.1016/0027-5107(77)90116-6

Cited by 8 publications

(1 citation statement)

References 16 publications

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“…There is a pronounced tendency for chromatid interchanges in mammalian cells to adopt a cruciform configuration (Wigglesworth and Savage, 1976), hence the term 'quadriradial'. This configuration, coupled with the very strong and precise pairing affinity of sister chromatids, enhances the ease with which pattern disruption is seen and break point positions determined (See Section 5.1).…”

Section: Interchanges (I 61)mentioning

confidence: 99%

Application of chromosome banding techniques to the study of primary chromosome structural changes.

Savage¹

1977

Journal of Medical Genetics

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Section: Interchanges (I 61)mentioning

confidence: 99%

Application of chromosome banding techniques to the study of primary chromosome structural changes.

Savage¹

1977

Journal of Medical Genetics

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Interchange and intra‐nuclear architecture

Savage

1993

Environ and Mol Mutagen

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For chromatin lesions to interact to form exchanges of any sort, it is obvious that contact between them must be made. However, the probability of such interaction is conditioned by other factors like time, initial separation, metabolic activity, and, in the case of chemically induced lesions, scheduled DNA synthesis. The irradiated nucleus was, for a long time, regarded as a "bag of broken chromosomes" with the severed ends free to move around and find partners with which to form illegitimate reunions. Many of these would be seen at following metaphase as intra- and interchanges. Evidence is rapidly accumulating which indicates that this picture of the nucleus is false. We know now that chromosomes occupy highly localised domains with limited movement, and that there is no massive intermingling; that much of the chromatin is compacted and splinted with proteins and so precluded from exchange-type contact; that most of the chromatin is looped and "fixed" into an intra-nuclear protein scaffold or skeleton; that some chromatin is spun-out and associated with the nuclear envelope in the vicinity of the pore-complexes. Thus it would appear that movement, in the sense envisaged by early workers, is curtailed, and that only a proportion (probably a small proportion) of the chromatin is actually "at-risk" with respect to interchange formation. Where then does interchange take place? Are the "sites" pre-existent, or can proximity requirements be realised after radiation exposure? In what ways will the intra-nuclear architecture influence exchange? These are some of the questions which are considered in this paper.

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The production of chromosome structural changes by radiation

Savage¹

1989

Experientia

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This paper attempts an update and comment upon some of the topics of chromosome aberration formation which Lea raised in Chapter VI of his classic work 'Actions of Radiations on living Cells'. Only the first nine sections of this chapter are covered, which deal primarily with the qualitative aspects of aberrations, their formation, classification and interrelationships. In commenting upon these topics, pertinent references are made to work with mammalian and human cells. Increased knowledge of the importance of DNA as a fundamental target and the integral part it plays in the complex structure of the chromosome, coupled with cellular techniques not available to these earlier workers necessitate some revision and modification of early ideas. However, inspite of the enormous accumulation of data and ideas since the original work was published in 1946, the foundation that these early workers laid is still very solid. Surprisingly, we are still puzzled by many of the problems that perplexed them.

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A comparison of the geometric configurations adopted by radiation-induced chromatid interchanges in animals and plants

Cited by 8 publications

References 16 publications

Application of chromosome banding techniques to the study of primary chromosome structural changes.

Application of chromosome banding techniques to the study of primary chromosome structural changes.

Interchange and intra‐nuclear architecture

The production of chromosome structural changes by radiation

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