A Comparison of the Efficacy, Safety, and Patient Satisfaction of Ondansetron Versus Droperidol as Antiemetics for Elective Outpatient Surgical Procedures

Fortney, Jennifer T.; Gan, Tong J.; Graczyk, Sarena G.; Wetchler, Bernard V.; Melson, Timothy; Khalil, Sara; McKenzie, Ray; Parrillo, Stephen; Glass, Peter S. A.; Moote, Carol A.; Wermeling, Daniel P.; Parasuraman, T.V.; Duncan, Benjamin; Creed, Mary R.

doi:10.1213/00000539-199804000-00011

Cited by 146 publications

(57 citation statements)

References 25 publications

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“…In this study, the incidence of PONV was 17% after using 2.5 mg droperidol. It has been reported that the incidences of PONV were 37% after using 0.625 mg droperidol and 31% after using 1.25 mg droperidol [6]. With increasing doses, droperidol's anti-vomiting effi cacy improved considerably, although doses beyond 2.5 mg did not further increase effi cacy [7].…”

Section: Discussionmentioning

confidence: 99%

The use of droperidol decreases postoperative nausea and vomiting after gynecological laparoscopy

2007

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We evaluated whether or not routine prophylaxis with 2.5 mg of droperidol would efficiently prevent postoperative nausea and vomiting (PONV). Fifty-two patients scheduled for elective gynecological laparoscopic surgery were eligible for this study. Anesthesia was induced using propofol, fentanyl, and vecuronium, and maintained with sevoflurane in nitrous oxide, fentanyl, and vecuronium. Patients were randomized to one of two groups: group 1 patients (n = 23) received 2.5 mg droperidol intravenously when the surgery was started, while group 2 patients (n = 29) did not receive any droperidol. At the conclusion of the surgery, the patient was extubated on satisfactory emergence from general anesthesia. Any episodes of nausea and vomiting, rescue medications, and adverse effects were recorded until the next morning after the surgery. There were no differences in the duration of anesthesia on surgery between the groups, but the total fentanyl dose in group 1 was higher than that in group 2. Episodes of nausea and vomiting and the need for metoclopramide in group 1 were lower than in group 2, though the total fentanyl dose in group 1 was higher than in group 2. There were no differences in the need for analgesics between the groups. The use of 2.5 mg droperidol safely decreased PONV after gynecological laparoscopy.

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Section: Discussionmentioning

confidence: 99%

The use of droperidol decreases postoperative nausea and vomiting after gynecological laparoscopy

2007

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“…We analyzed data collected in a previously published large multicenter study [2] to assess the effectiveness of different antiemetics for the treatment of established PONV in patients who failed prophylaxis.…”

Section: Methodsmentioning

confidence: 99%

“…Moreover, it is unclear if an antiemetic acting on a different receptor system would constitute a better treatment option in patients who experience PONV despite receiving a prophylactic antiemetic. We reexamined the database of a previously published large multicenter study to determine the efficacy of rescue antiemetics in patients who failed prophylaxis with ondansetron 4 mg and droperidol 0.625 to 1.25 mg [2]. We hypothesized that in patients who fail prophylaxis with one antiemetic, a rescue agent working at a different receptor would have a higher success rate compared with a repeat dose of the same antiemetic used for prophylaxis.…”

Section: Introductionmentioning

confidence: 99%

The effectiveness of rescue antiemetics after failure of prophylaxis with ondansetron or droperidol: a preliminary report

Habib

Gan

2005

Journal of Clinical Anesthesia

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“…Although ondansetron (an antagonist of the 5-HT3 receptor), is as effective as older antiemetics such as droperidol [97] or cyclizine [98], it avoids most of their adverse effects. Ondansetron given at the end of surgery results in a significantly greater antiemetic effect, compared with preinduction dosing [99].…”

Section: Antiemetic Medicationsmentioning

confidence: 99%

Anesthesia for laparoscopy: a review

Gerges

Kanazi

Jabbour-Khoury

2006

Journal of Clinical Anesthesia

221

159

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A Comparison of the Efficacy, Safety, and Patient Satisfaction of Ondansetron Versus Droperidol as Antiemetics for Elective Outpatient Surgical Procedures

Cited by 146 publications

References 25 publications

The use of droperidol decreases postoperative nausea and vomiting after gynecological laparoscopy

The use of droperidol decreases postoperative nausea and vomiting after gynecological laparoscopy

The effectiveness of rescue antiemetics after failure of prophylaxis with ondansetron or droperidol: a preliminary report

Anesthesia for laparoscopy: a review

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