The effectiveness of rescue antiemetics after failure of prophylaxis with ondansetron or droperidol: a preliminary report

Habib, Ashraf S.; Gan, Tong J.

doi:10.1016/j.jclinane.2004.04.004

Cited by 77 publications

(32 citation statements)

References 8 publications

(9 reference statements)

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“…Droperidol showed a high effectivity to prevent PONV especially in combination with the 5-HT 3 antagonist ondansetron in patients with an increased risk of PONV [9][10] . In 2001 the FDA pointed out their concerns of QT prolongation and torsade de pointes tachycardia related to the use of droperidol in a black box warning [11] .…”

mentioning

confidence: 99%

Haloperidol versus Haloperidol plus Ondansetron for the Prophylaxis of Postoperative Nausea and Vomiting after Ophthalmologic Surgery

Dagtekin

Wiese²,

Wolter³

et al. 2009

Pharmacology

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Introduction: In this prospective, randomized, and double-blinded study we investigated the efficacy of haloperidol (10 μg/kg) and the combination of haloperidol (10 μg/kg) with ondansetron (0.1 mg/kg) for the prophylaxis of postoperative nausea and vomiting (PONV) after ophthalmologic surgery. Methods: 60 patients (ASA status 1–3) with risk factors for PONV (female, non-smoker, motion sickness or PONV in history, opioids for postoperative analgesia) undergoing retinal or strabismus surgery were included into the study and randomised to the haloperidol group (H-Group) or the haloperidol-ondansetron group (H/O-Group). 20 min before the end of anaesthesia the study medication was given. Nausea, vomiting, pain scores, and adverse events were assessed postoperatively over 24 h. Results: The incidence of PONV was lower for the H/O-Group (23 vs. 57% for the H-Group). Especially the incidence of vomiting was reduced for the H/O-Group (7 vs. 27% in the H-Group). No significant differences could be detected regarding adverse events. Conclusion: The single use of haloperidol for the prophylaxis of PONV is doubtful. Better results were obtained with the combination therapy of haloperidol with ondansetron, especially for vomiting.

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mentioning

confidence: 99%

Haloperidol versus Haloperidol plus Ondansetron for the Prophylaxis of Postoperative Nausea and Vomiting after Ophthalmologic Surgery

Dagtekin

Wiese²,

Wolter³

et al. 2009

Pharmacology

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“…5-HT 3 -Antagonisten eignen sich dazu nicht [14,19], und die Dexamethasongabe zu wiederholen, ist nicht sinnvoll [13]. Rescue-Medikamente sollen über andere Wirkmechanismen wie Dopamin-, Histamin-oder Neurokininrezeptoren agieren [22] [8,25,26].…”

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„Low-dose“-Droperidol-Gabe bei Kindern

et al. 2012

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“…En el caso de que se haya usado terapia doble deben buscarse fármacos alternativos. Habib y Gan observaron que en casos de fracaso de la profilaxis con ondansetrón o droperidol, la prometazina o dimenhidrinato podrían ser útiles (57). Si se ha usado la triple terapia y ocurren vómitos en el postoperatorio inmediato, ningún fármaco debe repetirse en las primeras 6 horas desde su administración y es preciso buscar otras opciones (prometazina, escopolamina, metoclopramida, propofol).…”

Section: Tratamiento En El Adultounclassified

Recomendaciones de prevención y tratamiento de las náuseas y vómitos postoperatorios y/o asociados a las infusiones de opioides

Gómez-Arnau

Aguilar

Bovaira

et al. 2010

Revista Española de Anestesiología y Reanimación

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Postoperative nausea and vomiting (PONV) causes patient discomfort, lowers patient satisfaction, and increases care requirements. Opioid-induced nausea and vomiting (OINV) may also occur if opioids are used to treat postoperative pain. These guidelines aim to provide recommendations for the prevention and treatment of both problems. A working group was established in accordance with the charter of the Sociedad Española de Anestesiología y Reanimación. The group undertook the critical appraisal of articles relevant to the management of PONV and OINV in adults and children early and late in the perioperative period. Discussions led to recommendations, summarized as follows: 1) Risk for PONV should be assessed in all patients undergoing surgery; 2 easy-to-use scales are useful for risk assessment: the Apfel scale for adults and the Eberhart scale for children. 2) Measures to reduce baseline risk should be used for adults at moderate or high risk and all children. 3) Pharmacologic prophylaxis with 1 drug is useful for patients at low risk (Apfel or Eberhart 1) who are to receive general anesthesia; patients with higher levels of risk should receive prophylaxis with 2 or more drugs and baseline risk should be reduced (multimodal approach). 4) Dexamethasone, droperidol, and ondansetron (or other setrons) have similar levels of efficacy; drug choice should be made based on individual patient factors. 5) The drug prescribed for treating Este trabajo ha sido financiado mediante la concesión de una subvención de ProStrakan Farmacéutica SL a la Sociedad Española de Anestesiología, Reanimación y Terapéutica del Dolor.Aceptado para su publicación en agosto de 2010.Rev. Esp. Anestesiol. Reanim. 2010; 57: 508-524. Reproducido con permiso de REDAR.

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The effectiveness of rescue antiemetics after failure of prophylaxis with ondansetron or droperidol: a preliminary report

Cited by 77 publications

References 8 publications

Haloperidol versus Haloperidol plus Ondansetron for the Prophylaxis of Postoperative Nausea and Vomiting after Ophthalmologic Surgery

Haloperidol versus Haloperidol plus Ondansetron for the Prophylaxis of Postoperative Nausea and Vomiting after Ophthalmologic Surgery

„Low-dose“-Droperidol-Gabe bei Kindern

Recomendaciones de prevención y tratamiento de las náuseas y vómitos postoperatorios y/o asociados a las infusiones de opioides

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