A comparison of the effects of droperidol and the combination of droperidol and ondansetron on postoperative nausea and vomiting for patients undergoing laparoscopic cholecystectomy

Awad, Imad T.; Murphy, D.M.; Stack, D.; Swanton, B. J.; Meeke, R.; Shorten, George

doi:10.1016/s0952-8180(02)00394-x

Cited by 21 publications

(16 citation statements)

References 39 publications

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“…Multiple Pharmacologic Agents for Prophylaxis of Nausea and Vomiting. New RCTs comparing two antiemetic drugs with single antiemetic drug controls corroborate findings reported in the original Guidelines indicating that antiemetic combinations are effective in the prophylaxis of postoperative nausea and vomiting (Category A2-B evidence) with no differences in headache, dizziness, drowsiness, anxiety, or akathisia/restlessness reported 3,10,11,26,36,42,[57][58][59][60][61][62][63][64][65][66] (Category A2-E evidence). These RCTs consisted of comparisons among a variety of drug combinations, and the number of studies evaluating similar drug combinations was insufficient for meta-analysis.…”

Section: A1-e Evidence)supporting

confidence: 59%

Practice Guidelines for Postanesthetic Care

et al. 2013

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Section: A1-e Evidence)supporting

confidence: 59%

Practice Guidelines for Postanesthetic Care

et al. 2013

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“…The prophylactic antiemetic efficacy of combined ondansetron 4 mg and droperidol 1.25 mg administered IV immediately after induction of anesthesia is superior to that of droperidol alone in preventing PONV after LC [58]. A combination of granisetron 3 mg and droperidol 1.25 mg is more effective than each antiemetic alone administered IV before a surgical procedure in the prevention of PONV after LC [59].…”

Section: Combination Antiemetic Therapymentioning

confidence: 95%

“…Combination antiemetic therapy often is effective for preventing PONV in patients undergoing LC [58][59][60][61]. The prophylactic antiemetic efficacy of combined ondansetron 4 mg and droperidol 1.25 mg administered IV immediately after induction of anesthesia is superior to that of droperidol alone in preventing PONV after LC [58].…”

Section: Combination Antiemetic Therapymentioning

confidence: 99%

RETRACTED ARTICLE: Management of postoperative nausea and vomiting in patients undergoing laparoscopic cholecystectomy

Fujii

2010

Surg Endosc

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The common and distressing complications of postoperative nausea and vomiting (PONV) are the main concern of 40-70% of patients undergoing laparoscopic cholecystectomy (LC). The first step in preventing PONV after LC is to reduce the risk factors involving patient characteristics, surgical procedure, anesthetic technique, and postoperative care. Particularly, the use of propofol-based anesthesia can reduce the incidence of PONV after LC. Second, prophylactic antiemetics including antihistamines (dimenhydrinate), phenothiazines (perphenazine), butyrophenones (droperidol), benzamides (metoclopramide), dexamethasone, and serotonin receptor antagonists (ondansetron, granisetron, tropisetron, dolasetron, and ramosetron) are available for preventing PONV after LC. Third, antiemetic therapy combined with a serotonin receptor antagonist (ondansetron, granisetron) and droperidol or dexamethasone is highly effective in the prevention of PONV after LC. Fourth, acupressure at the P6 point is a nonpharmacologic technique that is as effective as ondansetron for preventing PONV after LC. Knowledge regarding the risk factors for PONV and antiemetics is needed for the management of PONV after LC.

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“…La combinación de 2 medicamentos antieméticos es efectiva en la profilaxis de náusea y vómito postoperatorio (evidencia categoría A2-B), sin diferencias en los efectos secundarios como cefalea, mareo, somnolencia e inquietud 24,31,32,48,53,56,[68][69][70][71][72][73][74][75][76][77] .…”

Section: Combinacionesunclassified