A Comparison of the Cytotoxicity and Proinflammatory Cytokine Production of EndoSequence Root Repair Material and ProRoot Mineral Trioxide Aggregate in Human Osteoblast Cell Culture Using Reverse-Transcriptase Polymerase Chain Reaction

Ciasca, Maria Isabel Filgueiras Lima; Aminoshariae, Anita; Jin, Ge; Montagnese, Thomas A.; Mickel, Andre

doi:10.1016/j.joen.2011.12.004

Cited by 54 publications

(35 citation statements)

References 24 publications

(35 reference statements)

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“…Moreover, cytotoxicity of EndoSequence was similar to MTA in both freshly mixed as well as set conditions. Similar results were reported by Ciasca M et al (2012) 16 and Damas BA et al (2011). 17 In a comparative study done by Guven EP et al (2013) 18 both MTA and EndoSequence have been shown to have 'Apatite-forming ability'.…”

Section: Discussionsupporting

confidence: 90%

A Comparative Evaluation of Sealing Ability of Endosequence Bc Sealer and Proroot Mta as Root Canal Sealer: An Ex Vivo Study

Sroa¹,

Sidhu²,

Sharma³

2017

jemds

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BACKGROUNDThe most common method of obturation uses semisolid material such as gutta-percha in combination with a root canal sealer. The sealers must preferably stimulate the process of apical and periapical repair along with providing a hermetic seal. MATERIALS AND METHODSA total of 38 single rooted freshly extracted mandibular teeth were selected and divided into two groups with 15 samples each; Group A (obturated with EndoSequence BC sealer) and Group B (obturated with ProRoot MTA ) and 4 samples each were used for positive control and negative control groups. Sealing ability of the two sealers was evaluated using Microbial Leakage test. RESULTSThe results of the study showed that 5 samples leaked in Group A (33.33%) and 6 samples leaked in Group B (40%). The results of this study suggest that the percentage of specimens without leakage was higher for Group A when compared with Group B. Moreover, early leakage was observed in samples with ProRoot MTA than with EndoSequence BC sealer. However, on applying Mann-Whitney test, the difference was found to be statistically insignificant. Hence, it can be inferred that 'EndoSequence BC Sealer' has comparable sealing ability as compared to 'ProRoot MTA'. CONCLUSIONIt may be concluded that 'EndoSequence BC Sealer' being antibacterial, hydrophilic, bioactive, biocompatible, aluminium-free nanoparticulate bioceramic sealer having superior handling characteristics may be recommended for clinical use. However, before any definite conclusion can be drawn, meticulous studies, a larger number of samples and clinical evaluation for longer duration should be encouraged to evaluate the efficacy of these sealers and potential for achieving the hermetic seal. BACKGROUNDEndodontic sealers are necessary to seal the space between the dentinal walls and the obturating core interface. Moreover, sealers fill the voids and irregularities in the root canal, lateral and accessory canals, and spaces between core materials.Recently, challenges in handling properties of sealers have now been met with the new 'EndoSequence bioceramic sealer' composed of zirconium oxide, calcium silicates, calcium phosphate monobasic and calcium hydroxide along with filler and thickening agents. Since the literature is deficient as regard the sealing ability of EndoSequence bioceramic sealer, the purpose of this study is to evaluate and compare the sealing ability of 'EndoSequence BC sealer (Brassler, Savannah, GA)' in comparison with white 'Pro-Root MTA (Dentsply, Tulsa Dental, Johnson City, USA)' when used as a root canal sealer in an ex vivo study.

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Section: Discussionsupporting

confidence: 90%

A Comparative Evaluation of Sealing Ability of Endosequence Bc Sealer and Proroot Mta as Root Canal Sealer: An Ex Vivo Study

Sroa¹,

Sidhu²,

Sharma³

2017

jemds

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“…To date, polymerase chain reaction (PCR) is frequently adopted for genetic amplification testing (Hindson et al 2011;Saunders et al 2013). Albeit the impressive progress in developing PCR-based analyses has been made in recent years (Chan et al 2014), the extensive application of PCR still remains a challenge associated with its inherent drawbacks, such as the extensive instrument, complex operation, and costly optical labels (Anderson et al 2012;Ciasca et al 2012;Gray et al 2011;Nguyen et al 2012). Thus, developing alternative approaches is currently a subject of concern.…”

Section: Introductionmentioning

confidence: 99%

Intelligent DNA machine for the ultrasensitive colorimetric detection of nucleic acids

Qian

et al. 2016

Biosensors and Bioelectronics

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“…Um material ideal utilizado para reparo endodôntico deve ser biocompatível, radiopaco, antibacteriano, dimensionalmente estável, fácil de manipular, além disso, não deve ser afetado pela contaminação sanguínea 10 . As propriedades físico-quí-micas de liberação de Ca2 +, pH, e radiopacidade conferem aos cimentos biocerâmicos características favoráveis para emprego em endodontia 7 .…”

Section: Discussionunclassified

“…Os materiais EndoSequence Root Repair Material (ERRM) 10,13 , BioAggregate e iRoot 11 , ProRoot MTA and MTA-Angelus 13 e Endosequence BC sealer 14,18 apresentaram biocompatibilidade aceitável, não induzindo efeitos citotóxicos críticos 12 . Um material bioativo é capaz de interagir com tecidos vivos, resultando na formação de uma camada de apatita, biomineralização, na interface material-tecido 39,40 .…”

Section: Discussionunclassified

Cimentos biocerâmicos em endodontia: revisão de literatura

Lima¹,

Santos²,

Pedrosa³

et al. 2017

Rev. da Fac. de Odontologia, UPF

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Cimentos biocerâmicos vêem se tornando populares na ndodontia como material obturador do sistema de canais radicular devido às suas várias vantagens. Objetivo: Revisar a literatura atualmente disponível sobre as propriedades de cimentos biocerâmicos na endodontia. Metodologia: Uma pesquisa bibliográfica exploratória foi realizada utilizando as bases de dados eletrônicas Public Medline (PubMed), Scopus, Embase, e Web of Science empregando o termo de busca “Bioceramic” AND “Endodontic”. Os critérios de inclusão foram: artigos de pesquisas originais e ensaios clínicos publicados em português, espanhol e inglês. Não foram aplicados limites a data de publicação. Resultados: Foram identificados 30 estudos que abordaram propriedades de cimentos biocerâmicos em endodontia publicados em um período de 7 anos (2011-2017). As propriedades e características vantajosas destacadas nos estudos foram: biocompatibilidade, citotoxicidade, bioatividade, capacidade de manchamento dentário, radiopacidade, pH e extravasamento (extravasamento não se enquadra como propriedade), adaptação marginal, resistência de união, resistência a fratura das raízes, capacidade seladora, e propriedades antibacterianas. Conclusão: Os estudos selecionados para esta revisão de literatura mostram que os cimentos endodônticos biocerâmicos apresentam propriedades promissoras para serem utilizados no tratamento de canais radiculares.

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A Comparison of the Cytotoxicity and Proinflammatory Cytokine Production of EndoSequence Root Repair Material and ProRoot Mineral Trioxide Aggregate in Human Osteoblast Cell Culture Using Reverse-Transcriptase Polymerase Chain Reaction

Cited by 54 publications

References 24 publications

A Comparative Evaluation of Sealing Ability of Endosequence Bc Sealer and Proroot Mta as Root Canal Sealer: An Ex Vivo Study

A Comparative Evaluation of Sealing Ability of Endosequence Bc Sealer and Proroot Mta as Root Canal Sealer: An Ex Vivo Study

Intelligent DNA machine for the ultrasensitive colorimetric detection of nucleic acids

Cimentos biocerâmicos em endodontia: revisão de literatura

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