A comparison of the biological features between prostate cancers arising in the transition and peripheral zones

Sakai, Iori; Harada, Kiyoshi; Hara, Isao; Eto, Hiroshi; Miyake, Hideaki

doi:10.1111/j.1464-410x.2005.05678.x

Cited by 48 publications

(43 citation statements)

References 20 publications

(36 reference statements)

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“…Previous comparisons of peripheral-and transition-zone cancers have given conflicting results. Cancers arising in these two zones have distinct morphological and immunohistochemical characteristics and it has been reported that transition-zone cancers are associated with more favourable pathological features (Grignon and Sakr, 1994;Greene et al, 1995;Sakai et al, 2005). In contrast, as judged by biochemical recurrence, there appeared to be no difference in outcome between transition-zone and peripheral-zone cancers following prostatectomy (Sakai et al, 2005;Chun et al, 2007).…”

Section: Ets Gene Rearrangements In Prostate Tissues J Clark Et Almentioning

confidence: 65%

Complex patterns of ETS gene alteration arise during cancer development in the human prostate

et al. 2007

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An ERG gene 'break-apart' fluorescence in situ hybridization (FISH) assay has been used to screen whole-mount prostatectomy specimens for rearrangements at the ERG locus. In cancers containing ERG alterations the observed pattern of changes was often complex. Different categories of ERG gene alteration were found either together in a single cancerous region or within separate foci of cancer in the same prostate slice. In some cases the juxtaposition of particular patterns of ERG alterations suggested possible mechanisms of tumour progression. Prostates harbouring ERG alterations commonly also contained cancer that lacked rearrangements of the ERG gene. A single trans-urethral resection of the prostate specimen examined harboured both ERG and ETV1 gene rearrangements demonstrating that the observed complexity may, at least in part, be explained by multiple ETS gene alterations arising independently in a single prostate. In a search for possible precursor lesions clonal ERG rearrangements were found both in high grade prostatic intraepithelial neoplasia (PIN) and in atypical in situ epithelial lesions consistent with the diagnosis of low grade PIN. Our observations support the view that ERG gene alterations represent an initiating event that promotes clonal expansion initially to form regions of epithelial atypia. The complex patterns of ERG alteration found in prostatectomy specimens have important implications for the design of experiments investigating the clinical significance and mechanism of development of individual prostate cancers.

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Section: Ets Gene Rearrangements In Prostate Tissues J Clark Et Almentioning

confidence: 65%

Complex patterns of ETS gene alteration arise during cancer development in the human prostate

et al. 2007

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“…16 In addition, transition zone tumors also express lower levels of p53 and bcl-2 than peripheral zone tumors. 16,17 These intrinsic biological difference between transition zone and peripheral zone tumors may also contribute to their different clinical behaviors.…”

Section: Discussionmentioning

confidence: 99%

“…[10][11][12][13] Some studies have suggested that there are differential expression levels of proliferative genes and oncogenes between transition and peripheral zone tumors, which may contribute to their clinical and biological differences. [14][15][16][17] However, to our knowledge, the role of TMPRSS2-ERG gene fusion in the zonal origin of prostate cancer has not been studied. In this study, we evaluated the TMPRSS2-ERG gene fusion in prostate cancers arising from the transition zone in comparison with those arising from the peripheral zone.…”

mentioning

confidence: 99%

Prostate cancer of transition zone origin lacks TMPRSS2–ERG gene fusion

et al. 2009

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Recent studies have shown a unique chromosomal rearrangement that leads to the fusion of 5 0 -transmembrane protein serine proteinase-2 (TMPRSS2) with the EST-related gene (ERG) in prostate cancer. In this study, we used fluorescence in situ hybridization to evaluate TMPRSS2-ERG gene fusion in prostate cancer of different zonal origins. Radical prostatectomy specimens with multifocal prostate cancer were obtained from 30 patients who were treated at our institution. Two separate tumor foci in each specimen, one in the peripheral zone and the other in the transition zone, were selected for gene fusion analysis. The selected peripheral zone tumor foci had a mean Gleason score of 6.8 (range, 6-7) and a mean tumor volume of 1.2 cm 3 (range, 0.1-4.6 cm 3 ). The selected transition zone tumor foci had a mean Gleason score of 6.7 (range, 5-8) and a mean tumor volume of 4.0 cm 3 (range, 0.5-9.0 cm 3 ). ERG gene rearrangement was not observed in any transition zone tumors; however, it was found in the peripheral zone tumors in 13 cases (43%). In 10 cases, the rearrangement was associated with the deletion of the 5 0 -end of ERG. In conclusion, we found that TMPRSS2-ERG gene fusion is associated with the zonal origin of prostate cancer. This gene fusion is prevalent in prostate cancer arising from the peripheral zone, but is lacking in prostate cancer arising from the transition zone.

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“…The peripheral zone (PZ) is the area where most prostate cancers grow [3]. Moreover, cancers of these two zones exhibit different behaviors [4]. Thus, it appears important to separate them in order to apply different analysis algorithms.…”

Section: Introductionmentioning

confidence: 99%

Gland and Zonal Segmentation of Prostate on T2W MR Images

et al. 2016

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For many years, prostate segmentation on MR images concerned only the extraction of the entire gland. Currently, in the focal treatment era, there is a continuously increasing need for the separation of the different parts of the organ. In this paper, we propose an automatic segmentation method based on the use of T2W images and atlas images to segment the prostate and to isolate the peripheral and transition zones. The algorithm consists of two stages. First, the target image is registered with each zonal atlas image then the segmentation is obtained by the application of an evidential C-Means clustering. The method was evaluated on a representative and multi-centric image base and yielded mean Dice accuracy values of 0.81, 0.70, and 0.62 for the prostate, the transition zone, and peripheral zone, respectively.

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A comparison of the biological features between prostate cancers arising in the transition and peripheral zones

Cited by 48 publications

References 20 publications

Complex patterns of ETS gene alteration arise during cancer development in the human prostate

Complex patterns of ETS gene alteration arise during cancer development in the human prostate

Prostate cancer of transition zone origin lacks TMPRSS2–ERG gene fusion

Gland and Zonal Segmentation of Prostate on T2W MR Images

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