A comparison of the available phosphodie­sterase-5 inhibitors in the treatment of erectile dysfunction: a focus on avanafil

Abstract

BackgroundNumerous pathways can lead to erectile dysfunction (ED) in patients, with some patients having multiple causes. Regardless of the etiology, ED has been successfully treated in many patients with the advent of oral phosphodiesterase-5 inhibitors (PDE5Is). With the release of avanafil, there are currently four PDE5I options available, and choosing between them should be based on patient-specific considerations and preferences.ObjectiveTo review the treatment of ED with PDE5Is, taking into account the effectiveness, safety, and patient satisfaction of these agents, as well as avanafil’s place in therapy.MethodsA PubMed search was completed to find articles published in English studying patient satisfaction and adherence to ED medication. Additional searches looked specifically for any data regarding the use of avanafil.ResultsED is effectively treated in most patients with PDE5Is, with the most common side effects from the medications being headache, flushing, and visual disturbances. Patients have identified many different factors, such as efficacy, side effects, duration of action, and daily use, in determining overall satisfaction and the right medication for them. While avanafil does not have any patient satisfaction trials to date, it has been proven to be a safe and effective treatment for ED with possibly the fastest onset of action and fewer visual disturbances than its competitors.ConclusionAvanafil along with the other PDE5Is has shown to be a safe and effective oral treatment for ED, with avanafil’s possible place in therapy for patients who want an on-demand option or as an alternative in patients who experience visual disturbances with the other agents.

The devil is in the details: an analysis of the subtleties between phosphodiesterase

“…Tadalafil has the longest duration of action at 24–36 hours. Onset of action is similar at 30 minutes ( 21 ). This prolonged period of efficacy has been seen as advantageous for some men.…”

“…Although the timing of onset is similar amongst these drugs ( 34 ), tadalafil has the longer half-life ( 34 ). In terms of rapid onset of effect, avanafil may hold a small advantage ( 21 ). In Table 1 below, one can find a review of the relevant pharmacokinetic factors for each drug.…”

Intervenções de enfermagem para incontinência urinária e disfunção sexual após prostatectomia radical

“…(34) These drugs should be ingested 30 to 60 minutes before sexual intercourse and come with headache, flushing and visual disorders as the main side effects. (35) Generally, when PDE5's are not effective in promoting erectile function after RP, intracavernous injections of prostaglandins are indicated. (34) International authors conducted a study to test the effectiveness of a nursing care plan for men with ED after RP.…”

Erectile Dysfunction: A Review of Comprehensive Treatment Options for Optimal Outcome

“…These medications differ in onset, duration of action, and side-effects. 127 The onset of sildenafil and vardenafil is 30-60 minutes with a duration of 10-12 hours. Tadalafil's onset is 15-30 minutes depending on dosage, with the longest duration of 36 hours.…”