A comparison of the anti-anaphylactic properties of ethanolamine and hydrocortisone

Abstract

A comparison of the anti-anaphylactic properties of ethanolamine and hydrocortisone P. GOADBY AND W. G. SMITH Both ethanolamine and hydrocortisone potentiate the anti-anaphylactic activity of mepyramine in actively sensitised guinea-pigs subjected to anaphylactic shock by exposure to aerosols of antigen solution. The effects of these two substances have now been compared. After intramuscular injection, the peak effect with ethanolamine occurred 1 hr later whereas with hydrocortisone it occurred 18 hr later. Both substances were also effective, after 45 min and 12 hr respectively, as aerosols. The optimum intramuscular dose of ethanolamine was 10 mg/kg and that of hydrocortisone 100 mg/kg. After aerosol administration, optimum effects were observed when 5% solutions of either drug were used.ORTISONE and synthetic analogues have been used successfully

Histamine release from the mast cells of guinea-pig lung

“…The histamine-releasing capacity of these substances has now been examined simultaneously with their effect on the mast cell population of guineapig lung tissues. The effect of pretreatment with anti-anaphylactic doses of theophylline (Firth & Smith, 1962), ethanolamine (Smith, 1961 ;Goadby & Smith, 1965), and hydrocortisone (Goadby & Smith, 1964;1965) on the subsequent reaction of guinea-pig lung mast cells to anaphylaxis in vitro is also reported. These experiments were made to see if they supported the view advanced by Boreus & Chakravarty (1960) that the mast cell is the main, and perhaps the only, source of histamine and SRS-A released from guinea-pig lung tissue by antigen or histamine releasing agents.…”