Investigation of leukotriene involvement in the vasopermeability response associated with guinea pig tracheal anaphylaxis: Comparison with cutaneous anaphylaxis

Woodward, David F.; Wasserman, Martin A.; Weichman, Barry M.

doi:10.1016/0014-2999(83)90025-0

Cited by 38 publications

(15 citation statements)

References 30 publications

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“…As in previous studies of ovalbumin-sensitized guinea-pigs, we found that both the increase in lung resistance and airway microvascular leakage was effectively inhibited by a histamine HI receptor antagonist (Woodward et al, 1983). In another study, pretreatment with chlorpheniramine significantly inhibited airway microvascular leakage in the trachea and main bronchi in ovalbumin-sensitized guinea-pigs challenged with intravenous antigen (Evans et al, 1988a).…”

Section: Resultssupporting

confidence: 64%

“…Similarly, in sensitized guinea-pigs pretreated with antihistamines, allergeninduced bronchoconstriction was found to be partly mediated by sulphidopeptide leukotrienes (Kreutner et al, 1989). Although Woodward et al (1983) did not find any inhibitory effect of FPL 55712, a leukotriene receptor antagonist, against airway microvascular leakage in the guinea-pig, the 5-lipoxygenase inhibitor A-63162 has recently been shown to inhibit both the bronchoconstrictor and airway microvascular leakage induced by ovalbumin aerosol in the guinea-pig (Hui et al, 1991). Thus, our guinea-pigs sensitized to TMA may show a different profile of mediator release when challenged with TMA-GPSA compared to ovalbumin.…”

Section: Resultsmentioning

confidence: 99%

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Involvement of inflammatory mediators in the airway responses to trimellitic anhydride in sensitized guinea‐pigs

James

Lötvall

Barnes

et al. 1992

British J Pharmacology

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1 We examined the effect of various pharmacological agents on the acute bronchoconstrictor response and airway microvascular leakage in a model of guinea-pig sensitization to trimellitic anhydride (TMA) a cause of low molecular weight occupational asthma in man. 2 Guinea-pigs were given intradermal injections of 0.1 ml of 0.3% TMA in corn oil; 21-28 days later, anaesthetized guinea-pigs were challenged with TMA conjugated to guinea-pig albumin by tracheal instillation. Changes in lung resistance were measured and airway microvascular leakage was quantified by measuring the extravasation of Evans blue dye into the airway tissue.3 Sensitized guinea-pig (n = 9 in each group) were pretreated with chlorpheniramine (2.5 mg kg-', i.v.), WEB 2086 (10 ±g kg-', i.v.), BW 4AC (50mg kg-', i.p.), nedocromil sodium (2% aerosol for 60 s) or vehicle alone. 4 Pretreatment with chlorpheniramine inhibited both the acute bronchoconstrictor response and the increase in airway microvascular leakage. WEB 2086 and nedocromil sodium partially inhibited the bronchoconstrictor response but had no significant effect on airway microvascular leakage. BW 4AC caused a non-significant reduction of the bronchoconstrictor response and airway microvascular leakage. 5 These results indicate that both the bronchoconstrictor response and the airway microvascular response in this model of sensitization is mediated to a large extent by histamine. PAF but not 5-lipoxygenase products also partially mediates the bronchoconstrictor response but not the airway microvascular leakage. Nedocromil sodium partially inhibits the bronchoconstrictor response only.

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Section: Resultssupporting

confidence: 64%

Section: Resultsmentioning

confidence: 99%

Involvement of inflammatory mediators in the airway responses to trimellitic anhydride in sensitized guinea‐pigs

James

Lötvall

Barnes

et al. 1992

British J Pharmacology

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“…This influence of the cys-LTs, which appeared to involve both direct and indirect pathways, was inhibited by either FPL 55712 (Woodward et al, 1983a) or pranlukast Bochnowicz and Underwood, 1995) indicating that a CysLT 1 receptor was involved.…”

Section: Diverse Effects Of Cysteinyl-leukotrienesmentioning

confidence: 96%

International Union of Pharmacology XXXVII. Nomenclature for Leukotriene and Lipoxin Receptors

et al. 2003

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“…In atopic asthma, allergen provocation induces the release of preformed and newly generated spasmogenic mediators from activated mast cells in the bronchial mucosa, and these mediators in duce immediate bronchoconstriction [21], Tokuyama et al [22] reported that antigen and other spasmogenic mediators induced not only airflow obstruction but also microvascular permeability, resulting in airway edema recognized as latephase airway obstruction. Indeed, histamine, leukotrienes and platelet-activating factor induce immediate broncho constriction and microvascular permeability in the airways of normal guinea pigs [23,24], Woodward et al [25] dem onstrated that the increase in lung resistance and airway mi crovascular leakage in sensitized guinea pigs was inhibited by the Hr receptor antagonist. However, using sensitized guinea pigs pretreated with an antihistaminic.…”

Section: Discussionmentioning

confidence: 99%

Effect of ZCR-2060, an Antiallergic Agent, on Antigen-Induced Immediate- and Late-Phase Increases in Airway Resistance in Sensitized Guinea Pigs

Yoshida

Omata

et al. 1995

Int Arch Allergy Immunol

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The effect of 2-[2-[4-(diphenylmethyl)-1-piperadinyl] ethoxy] benzoic acid maleate (ZCR-2060) on passive systemic anaphylaxis (PSA) and antigen-induced immediate- and late-phase increase in airway resistance (Rrs) in either passively or actively sensitized guinea pigs were investigated. ZCR-2060 inhibited PSA in guinea pigs. ID₅₀ values of ZCR-2060, ketotifen, terfenadine and cetirizine on PSA were 0.03, 0.02, 0.8 and 0.3 mg/kg, respectively, when administered orally 1 h before the antigen challenge. The protective effect of ZCR-2060 was observed until 12 h before the antigen challenge. Aeroantigen-induce immediate increase in Rrs in passively sensitized guinea pigs with and without metyrapone treatment was inhibited by ZCR-2060, ketotifen, terfenadine and cetirizine. In contrast, prednisolone did not affect the aeroantigen-induced immediate increase in Rrs in animals not treated with metyrapone, but significantly inhibited the metyrapone-induced enhanced immediate response. In actively sensitized animals, the immediate- and late-phase increases in Rrs were observed within 30 min and between 3 and 8 h after the aeroantigen challenge. Pretreatment with metyrapone accelerated both antigen-induced responses. ZCR-2060 (1 mg/kg) significantly inhibited both responses. Ketotifen (1 mg/kg), terfenadine (10 mg/ kg) and prednisolone (10 mg/kg) significantly the inhibited the late-phase response, but did not affect the immediate-phase response. In contrast, Cetirizine (10 mg/kg) did not affect either response. The effect of ZCR-2060 on late-phase response was stronger than that of ketotifen, terfenadine and cetirizine, and was almost the same as that of prednisolone. These results suggest that ZCR-2060 has a potent protective effect on immediate- and late-phase increases in Rrs.

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Investigation of leukotriene involvement in the vasopermeability response associated with guinea pig tracheal anaphylaxis: Comparison with cutaneous anaphylaxis

Cited by 38 publications

References 30 publications

Involvement of inflammatory mediators in the airway responses to trimellitic anhydride in sensitized guinea‐pigs

Involvement of inflammatory mediators in the airway responses to trimellitic anhydride in sensitized guinea‐pigs

International Union of Pharmacology XXXVII. Nomenclature for Leukotriene and Lipoxin Receptors

Effect of ZCR-2060, an Antiallergic Agent, on Antigen-Induced Immediate- and Late-Phase Increases in Airway Resistance in Sensitized Guinea Pigs

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