A Comparison of Systemic Inflammation-Based Prognostic Scores in Patients on Regular Hemodialysis

Kato, Akihiko; Tsuji, Takayuki; Sakao, Yukinori; Ohashi, Naro; Yasuda, Hideo; Fujimoto, Takao; Takita, Takako; Furuhashi, Mitsuyoshi; Kumagai, Hiromichi

doi:10.1159/000355148

Cited by 34 publications

(37 citation statements)

References 34 publications

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“…Moreover, Harrell's concordance index highlighted that GPS was superior to others in terms of discriminating good from poor. These results were kept in line with the work of Akihiko Kato, Proctor and Pan Q [24,30,31].…”

Section: Discussionsupporting

confidence: 75%

Glasgow Prognostic Score Is Superior to Other Inflammation-Based Scores in Predicting Survival of Diffuse Large B-Cell Lymphoma

Hao

Wei

Huang

et al. 2015

Blood

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Inflammation-based prognostic scores, such as the glasgow prognostic score (GPS), prognostic index(PI), prognostic nutritional index(PNI), neutrophil lymphocyte ratio(NLR), platelet lymphocyte ratio(PLR) was related to survival in many solid tumors. Recent study showed that GPS can be used to predict outcome in diffuse large B-cell lymphoma(DLBCL). However other inflammation related scores had not been reported in DLBCL, and it also remained unknown which of them was more useful to evaluate the survival in DLBCL. In this retrospective study, a number of 252 newly diagnosed and histologically proven DLBCL patients from January 2003 to December 2014 were included. An elevated GPS, PI, NLR, PNI and PLR were all associated with decreased overall survival(p=0.000, p=0.000, p=0.006, p=0.001 and p=0.001, respectively) and event-free survival (p=0.000, p=0.000, p=0.011, p=0.001 and p=0.009, respectively) in univariate analysis. Multivariate analysis indicated that GPS(RR=1.768, 95%CI=1.043-3.000, p =0.034) remained an independent prognostic predictor in DLBCL. The area under the curve of GPS (0.735, 95%CI=0.645-0.824) was greater than that of PI(0.710, 95%CI=0.621-0.799), PNI(0.600, 95%CI=0.517-0.683), NLR(0.572, 95%CI=0.503-0.642), and PLR(0.599, 95%CI=0.510-0.689) by Harrell's C-statistics. Especially in the DLBCL patients treated with R-CHOP, GPS also remained the most powerful inflammation-based prognostic score when comparing with PI, NLR, PNI and PLR (p=0.004, p=0.000, respectively for OS and EFS). In conclusion, these results indicate that Inflammation-based prognostic scores such as GPS, PI, NLR, PNI and PLR can be used to evaluate the outcome in DLBCL patients. Among them, GPS is the most powerful tool in predicting survival in DLBCL patients, even in the rituximab era. Disclosures No relevant conflicts of interest to declare.

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Section: Discussionsupporting

confidence: 75%

Glasgow Prognostic Score Is Superior to Other Inflammation-Based Scores in Predicting Survival of Diffuse Large B-Cell Lymphoma

Hao

Wei

Huang

et al. 2015

Blood

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Section: Discussionsupporting

confidence: 75%

Glasgow prognostic score is superior to other inflammation-based scores in predicting survival of diffuse large B-cell lymphoma

Feng

2015

Experimental Hematology

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“…In a number of studies, GPS scores were shown to be instrumental in making informed decisions on whether to proceed with antitumor chemotherapy in frail patients [22], in predicting clinical outcomes of hemodyalisis [23] and in both resectable and metastatic cancers [reviewed in 24]. In our study, the inflammatory GPS scores were not useful as predictors of multimorbidity, as only small percentages of each cohort had GPS above zero.…”

Section: Discussionmentioning

confidence: 59%

Age-independent rise of inflammatory scores may contribute to accelerated aging in multi-morbidity

et al. 2015

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Aging is associated with an increase in a chronic, low-grade inflammation. This phenomenon, termed “inflammaging” is also a risk factor for both morbidity and mortality in the elderly. Frequent co-occurrence of chronic diseases, known as multi-morbidity, may be explained by interconnected pathophysiology of these conditions, most of which depend on its inflammatory component. Here we present an analysis of the U.S. National Health and Nutrition Examination Survey data collected between 1999 and 2008, for the presence, and the number, of chronic diseases along with HDL-cholesterol, C-reactive protein, white blood cell count, lymphocyte percent, monocyte percent, segmented neutrophils percent, eosinophils percent, basophils percent, and glycohemoglobin levels. Importantly, even after adjustment for age and BMI, many inflammatory markers continued to be associated to multi-morbidity. C-reactive protein (CRP) levels and Glasgow Prognostic Score (GPS) were most dramatically increased in parallel with an accumulation of chronic diseases, and may be utilized as multi-morbidity predictors. These observations point at background inflammation as direct, age-independent contributor to an accumulation of the disease burden. Our findings also suggest a possibility that systemic inflammation associated with chronic diseases may explain accelerated aging phenomenon previously observed among the patients with heavy disease burden.

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A Comparison of Systemic Inflammation-Based Prognostic Scores in Patients on Regular Hemodialysis

Cited by 34 publications

References 34 publications

Glasgow Prognostic Score Is Superior to Other Inflammation-Based Scores in Predicting Survival of Diffuse Large B-Cell Lymphoma

Glasgow Prognostic Score Is Superior to Other Inflammation-Based Scores in Predicting Survival of Diffuse Large B-Cell Lymphoma

Glasgow prognostic score is superior to other inflammation-based scores in predicting survival of diffuse large B-cell lymphoma

Age-independent rise of inflammatory scores may contribute to accelerated aging in multi-morbidity

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