A comparison of survival, growth, and pulmonary function in patients with cystic fibrosis in Boston and Toronto

Corey, Mary; McLaughlin, Fiona; Williams, Mary H.; Levison, Henry

doi:10.1016/0895-4356(88)90063-7

Cited by 730 publications

(419 citation statements)

References 10 publications

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“…Nevertheless, our study highlights the major importance of pulmonary disease in malnutrition, but also the implication of PI and gastroesophageal reflux. Longitudinal studies demonstrated that the decline of lung function and undernutrition are related with each other (Corey et al, 1988;Kerem et al, 1992;Schoni & CasaultaAebischer, 2000) and that malnutrition may be expected to increase with advancing age (Nir et al, 1996;Steinkamp & Wiedemann, 2002). However, we observed that age and BMI were positively correlated and that patients with a severe malnutrition were significantly younger than the other patients.…”

Section: Abstract: Cystic Fibrosis; Malnutritionmentioning

confidence: 42%

Malnutrition in adults with cystic fibrosis

et al. 2004

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Section: Abstract: Cystic Fibrosis; Malnutritionmentioning

confidence: 42%

Malnutrition in adults with cystic fibrosis

et al. 2004

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“…Accordingly, weight was a highly significant parameter in univariate analysis of survival while awaiting LT in 67 consecutive patients listed for GF [5]. In the CF population, attempts to increase weight have a positive impact on survival [24]. In end-stage lung diseases, lean body mass seems to be a better tool to assess nutritional depletion and monitoring this parameter in lung transplant candidates is recommended.…”

Section: Discussionmentioning

confidence: 99%

Prevalence and consequences of nutritional depletion in lung transplant candidates

Schwebel

Pin²,

Barnoud³

et al. 2000

Eur Respir J

106

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Nutritional status was studied in lung transplant (LT) candidates. The hypotheses were that nutritional depletion was highly prevalent and lean body mass depletion was a risk factor for a higher mortality both before and after LT.Of 78 consecutive patients listed for LT, 16 (21%) died while on the waiting list, eight (10%) were alive awaiting LT, and 54 (69%) received a graft. Mean age was 42.3 4.4 (mean SD). Thirty-eight per cent had a diagnosis of bronchiectasis or cystic fibrosis (BRO/CF), 33% of emphysema, 20% of idiopathic pulmonary fibrosis (IPF) and 8% of primary pulmonary hypertension. Body mass index (BMI) was 20.4 4.3 kg . m 2 , weight was 87.9 16.6% of ideal body weight (IBW).Patients were classed into four nutritional groups according to IBW and creatinine height index (CHI): I: weight <90% IBW and CHI <60% of predicted (28% of cases); II: weight <90% IBW and CHI $60% (27%); III: weight $90% IBW and CHI <60% (17%); IV: weight $90% IBW and CHI $60% (28%). Overall, 72% were depleted corresponding to groups I, II and III. Lean body mass depletion occurred despite normal weight in 17% of the cases (group III). Subjects with BRO/CF were mostly in groups I, II, III whereas IPF were concentrated in group III. Lean body mass depletion was associated with more severe hypoxaemia, reduced 6-minute walking distance and a higher mortality while awaiting. After LT, duration of mechanical ventilation, time spent in intensive care unit (ICU) was related to initial body composition. Survival after LT was lowest in group III.To conclude, nutritional depletion in lung transplant candidates is highly prevalent and should be more precisely assessed with a special reference to lean body mass since it has specific consequences both while awaiting and after lung transplant. Attempts should be made to increase lean body mass before lung transplant. Eur Respir J 2000; 16: 1050±1055.

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“…A high REE combined with an increased ECA puts patients at risk of nutritional compromise. The occurrence of malnutrition has been associated with poor survival in patients with CF (Corey et al, 1988) and therefore the nutritional prescription should account for increased energy needs, especially when additional physical activities are incorporated into the lifestyle of a patient. In addition, efforts should be made to reduce the possibility of an inactive lifestyle, and physical activity promoted in conjunction with caloric supplementation, to ensure the maintenance of energy balance.…”

Section: Discussionmentioning

confidence: 99%

Energy cost of physical activity in cystic fibrosis

Richards

Davies²,

Bell³

2001

Eur J Clin Nutr

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Objective: The purpose of this study was to compare the energy cost of standardized physical activity (ECA) between patients with cystic ®brosis (CF) and healthy control subjects. Design: Cross-sectional study using patients with CF and volunteers from the community. Setting: University laboratory. Subjects: Fifteen patients (age 24.6 AE 4.6 y) recruited with consent from their treating physician and 16 healthy control subjects (age 25.3 AE 3.2) recruited via local advertisement. Interventions: Patients and controls walked on a computerised treadmill at 1.5 kmah for 60 min followed by a 60 min recovery period and, on a second occasion, cycled at 0.5 kp (kilopond), 30 rpm followed by a 60 min recovery. The ECA was measured via indirect calorimetry. Resting energy expenditure (REE), nutritional status, pulmonary function and genotype were determined. Results: The REE in patients was signi®cantly greater than the REE measured in controls (P 0.03) and was not related to the severity of lung disease or genotype. There was a signi®cant difference between groups when comparing the ECA for walking kg p FFM (P 0.001) and cycling kg p FFM (P 0.04). The ECA for each activity was adjusted (ECA adj ) for the contribution of REE (ECA kJ kg p FFM 120 min 71 7 REE kJ kg p FFM 120 min 71 ). ECA adj revealed a signi®cant difference between groups for the walking protocol (P 0.001) but no difference for the cycling protocol (P 0.45). This ®nding may be related to the fact that the work rate during walking was more highly regulated than during cycling. Conclusions: ECA in CF is increased and is likely to be explained by an additional energy-requiring component related to the exercise itself and not an increased REE.

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A comparison of survival, growth, and pulmonary function in patients with cystic fibrosis in Boston and Toronto

Cited by 730 publications

References 10 publications

Malnutrition in adults with cystic fibrosis

Malnutrition in adults with cystic fibrosis

Prevalence and consequences of nutritional depletion in lung transplant candidates

Energy cost of physical activity in cystic fibrosis

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