Malnutrition in adults with cystic fibrosis

Dray, Xavier; Kanaan, R.; Bienvenu, Thierry; Desmazes-Dufeu, N.; Dusser, Daniel; Marteau, P.; Hubert, D.

doi:10.1038/sj.ejcn.1602039

Cited by 48 publications

(46 citation statements)

References 15 publications

(14 reference statements)

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“…The S-K score was not used in three previous studies of the nutritional status in CF patients. (21)(22)(23) In contrast, there was no significant association between malnutrition and the S-K score in the study by Ziegler et al (24) Longitudinal studies have demonstrated that malnutrition can be expected to increase with aging. (31,32) However, it is interesting that our results showed that young age was a predictor of malnutrition only in the multivariable analysis.…”

Section: Discussioncontrasting

confidence: 39%

“…(21) In contrast, a study carried out in an adult tertiary CF center in France with 163 patients showed that 49.7% of the patients suffered from malnutrition. (22) That study also used the same methodology and the same cut-off points for classifying malnutrition. (22) A retrospective cross-sectional study conducted in São Paulo, Brazil, and involving 30 adolescents (in the 10.1-to 19.8-year age bracket), using a different methodology (BMI for age) to evaluate their nutritional status.…”

Section: Discussionmentioning

confidence: 99%

“…(22) That study also used the same methodology and the same cut-off points for classifying malnutrition. (22) A retrospective cross-sectional study conducted in São Paulo, Brazil, and involving 30 adolescents (in the 10.1-to 19.8-year age bracket), using a different methodology (BMI for age) to evaluate their nutritional status. (23) The cut-off points were the following: ≥ z-score −3 and < z-score −2 (thinness); z-score −2 and ≤ z-score +1 (normal weight); and > z-score +1 (overweight or obesity).…”

Section: Discussionmentioning

confidence: 99%

“…(7,14,19,20) The proportion of CF patients with malnutrition in the present study (24.7%) is similar to findings reported in other studies. (21)(22)(23)(24) A cross-sectional study conducted in Greece (21) and using the same methodology and the same cut-off points in order to classify nutritional status showed that 23% of 68 patients with CF were malnourished. However, that study involved 37 children and adolescents.…”

Section: Discussionmentioning

confidence: 99%

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Factors associated with malnutrition in adolescent and adult patients with cystic fibrosis

et al. 2017

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Objective: To determine the prevalence of malnutrition in patients attending an adult cystic fibrosis (CF) program and to investigate the associations of malnutrition with the clinical characteristics of those patients. Methods: This was a cross-sectional study involving patients with clinically stable CF patients (16 years of age or older). The patients underwent clinical assessment, nutritional assessments, pulmonary function tests, and pancreatic function assessment. They also completed a questionnaire regarding diet compliance. On the basis of their nutritional status, the patients were classified divided into three groups: adequate nutrition; at nutritional risk; and malnutrition. Results: The study has included 73 patients (mean age, 25.6 ± 7.3 years), 40 of whom (54.8%) were female. The mean body mass index was 21.0 ± 3.0 kg/m 2 and the mean FEV 1 was 59.7 ± 30.6% of predicted. In this sample of patients, 32 (43.8%), 23 (31.5%), and 18 (24.7%) of the patients were allocated to the adequate nutrition, nutritional risk, and malnutrition groups, respectively. The logistic regression analysis identified three independent factors associated with the risk of malnutrition: Shwachman-Kulczycki score, percent predicted FEV 1 ; and age. Conclusions: Malnutrition remains a common complication in adolescents and adults with CF, despite dietary advice. Malnutrition is associated with age, clinical severity, and lung function impairment.

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Section: Discussioncontrasting

confidence: 39%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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Factors associated with malnutrition in adolescent and adult patients with cystic fibrosis

et al. 2017

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“…1,2 It has been associated with both decline in lung function and low body mass index. 3,4 Traditionally oesophageal pH monitoring has been used to detect acid reflux, but more recently impedence pH studies has allowed more sensitive detection of not only acid, but also non-acid reflux. Fundoplication has been performed in children and adults with variable outcomes, but may reduce decline in forced expiratory volume (FEV 1 ) in those with poor lung function.…”

Section: Introductionmentioning

confidence: 99%

Gastroesophageal reflux causing nutritional failure and vomiting in a teenager with cystic fibrosis and respiratory failure

2011

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Association of Body Mass Index With Clinical Outcomes in Patients With Cystic Fibrosis

et al. 2022

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IMPORTANCEThe prevalence of overweight (body mass index [BMI] = 25-29.9 [calculated as weight in kilograms divided by height in meters squared]) and obesity (BMI Ն30) is increasing among patients with cystic fibrosis (CF). However, it is unclear whether there is a benefit associated with increasing weight compared with the reference range (ie, normal) in CF. OBJECTIVETo evaluate the association of altered BMI or body composition and clinical outcomes in patients with CF. DATA SOURCES For this systematic review and meta-analysis, the literature search was conducted November 2, 2020, of 3 databases: MEDLINE (via PubMed), Embase, and Cochrane Central Register of Controlled Trials. STUDY SELECTION Patients older than 2 years diagnosed with CF with altered body composition or BMI were compared with patients having the measured parameters within the reference ranges.Records were selected by title, abstract, and full text; disagreements were resolved by consensus.Cohort studies and conference abstracts were eligible; articles with no original data and case reports were excluded. DATA EXTRACTION AND SYNTHESISTwo authors independently extracted data, which were validated by a third author. Studies containing insufficient poolable numerical data were included in the qualitative analysis. A random-effects model was applied in all analyses. MAIN OUTCOMES AND MEASURES Pulmonary function, exocrine pancreatic insufficiency (PI),and CF-related diabetes (CFRD) were investigated as primary outcomes. Odds ratios (ORs) or weighted mean differences (WMDs) with 95% CIs were calculated. The hypothesis was formulated before data collection. RESULTSOf 10 524 records identified, 61 met the selection criteria and were included in the qualitative analysis. Of these, 17 studies were included in the quantitative synthesis. Altogether, 9114 patients were included in the systematic review and meta-analysis. Overweight (WMD, -8.36%; 95% CI, -12.74% to -3.97%) and obesity (WMD, -12.06%; 95% CI, -23.91% to -0.22%) were associated with higher forced expiratory volume in the first second of expiration compared with normal weight.The odds for CFRD and PI were more likely in patients of normal weight (OR, 1.49; 95% CI, 1.10 to 2.00) than in those who were overweight (OR, 4.40; 95% CI, 3.00 to 6.45). High heterogeneity was shown in the analysis of pulmonary function (I 2 = 46.7%-85.9%).

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Malnutrition in adults with cystic fibrosis

Abstract: Objective: To determine the prevalence and clinical features of malnutrition and its relationship with the CFTR genotype in a cystic fibrosis (CF) adult population. Design: Cross-sectional study. Setting:

Cited by 48 publications

References 15 publications

Factors associated with malnutrition in adolescent and adult patients with cystic fibrosis

Factors associated with malnutrition in adolescent and adult patients with cystic fibrosis

Gastroesophageal reflux causing nutritional failure and vomiting in a teenager with cystic fibrosis and respiratory failure

Association of Body Mass Index With Clinical Outcomes in Patients With Cystic Fibrosis

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