Physical and behavioral interventions have been shown to improve symptoms of advanced knee osteoarthritis, but do middle-aged, sedentary individuals with early-stage disease also benefit from these approaches, either alone or in combination?Knee osteoarthritis (oa) is a common chronic joint disease and a major contributor to long-term disability for which nonpharmacological conservative therapy is the cornerstone of management. exercise improves pain and function, 1 and is recommended by clinical guidelines. 2 there is also increasing emphasis on the use of self-management strategies to improve self-efficacy and empower individuals to become active participants in the management of their condition, 3 although effect sizes for this approach reported in the literature tend to be small. 4,5 Given that exercise and self-management programs address different aspects of knee oa, it might be supposed that a combined treatment program would be more effective than either alone. surprisingly, however, this hypothesis was not supported by the results of a study by mcKnight et al., 6 in which 273 sedentary individuals aged 35-64 years with early knee oa were enrolled in a strength-training program, a self-management program or a combined program. nonetheless, the study contributes specific new knowledge owing to its focus on younger individuals with early oa, its evaluation of a multimodal treatment program, and its use of a 2-year intervention to determine adherence and long-term outcomes.oa research has generally focused on older individuals with advanced disease and greater symptomatic and functional deficits. By contrast, the group included in this study had early knee oa with mild symptoms. interventions that target early-stage disease could be particularly important to limit the progression of symptoms and structural deterioration. However, in this study, neither radiography nor mri were used to determine the effects of the interventions on knee joint structure.all three treatment programs involved an initial 9-month phase of intensive contact followed by a second, 15-month phase during which contact was tapered. the low-to-moderate intensity exercise program targeted muscle strength, balance, range of motion and flexibility, consistent with common clinical practice, with supervised sessions in the first phase and self-directed exercise in the second phase. Given that the participants were healthy, relatively young and had mild symptoms, it is likely that they were capable of undertaking a more-intense program. although the type of exercise does not seem to influence clinical outcome, 1 the effects of exercise intensity have not been well-studied. 7 the self-management program comprised weekly 90-min classroom sessions for 12 weeks, then weekly telephone calls for the duration of the first phase; in the second phase, the phone calls reduced in frequency. the program components included education regarding coping and self-efficacy skills, and general exercise advice. these treatment programs were relatively time-intensi...