A Comparison of Some Cardiovascular Effects of Tubocurarine and Pancuronium in Dogs

Smith, G.; Proctor, Dominic W.; Spence, A.

doi:10.1097/00132586-197202010-00017

Cited by 2 publications

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“…The hmited literature available on the myocardial effects of tubocurare suggests that the drug exerts direct myocardial depressant effects (71,72). The hmited literature available on the myocardial effects of tubocurare suggests that the drug exerts direct myocardial depressant effects (71,72).…”

Section: Limitations Of Methodologymentioning

confidence: 99%

Studies of systolic mechanics and diastolic behavior of the left ventricle in the trained racing greyhound

et al. 1982

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Despite much interest in the effects of exercise on the myocardium, and the need to develop animal models which mimic conditions leading to cardiac hypertrophy, little attention has been focused on the trained racing greyhound. The current study compared two groups of anesthetized trained racing greyhounds (a total of 20 animals, 12 of whom were maintained for serial studies and 8 of whom were sacrificed for anatomic correlations) with 3 detrained greyhounds and 6 comparably sized mongrels. Systemic blood pressures, right and left heart pressures, ventricular mechanics and indices of diastolic behavior were compared. All measured indices of contractility (dp/dt, dp/dtDP40, Vce and Vmax) were lower in trained racing greyhounds than in mongrels although none achieved statistical significance. No significant difference in diastolic behavior was found between trained greyhounds and mongrels. While caution should be applied because of the small numbers of animals and the use of anesthesia, the lower than expected contractility found in trained racing greyhounds may reflect increased parasympathetic tone in the immediate post-training period. The normal diastolic behavior of the trained greyhound left ventricle contrasts to abnormal diastolic behavior found in models of chronic pressure overload.

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Section: Limitations Of Methodologymentioning

confidence: 99%

Studies of systolic mechanics and diastolic behavior of the left ventricle in the trained racing greyhound

et al. 1982

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“…In contrast to d-tubocurarine, which generally exerts a marked hypotensive effect, studies with pancuronium in several animal species have shown that the drug either has no effect or causes a slight rise in blood pressure Smith et al, 1970). Pancuronium did not enhance the blood pressure lowering effects of thiopentone and halothane, and occasionally counteracted the hypotensive effect of halothane to a certain extent Bonta and Buckett, 1969;Buckett and Bonta, 1966).…”

Section: Cardiovascular Effectsmentioning

confidence: 96%