A comparison of responses to bronchodilator drugs in chronic bronchitis and chronic asthma

Crompton, G.K.

doi:10.1136/thx.23.1.46

Cited by 57 publications

(16 citation statements)

References 14 publications

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“…The major importance of acetylcholine in asthma is indicated by observations that atropine often is clinically effective although it antagonizes this mediator only (cf. Crompton, 1968;Simonsson, 1977). The use of tracheal smooth muscle from guinea-pig was justified by findings that it may react similarly to more peripheral airways as well as to human isolated bronchi (Persson & Ekman, 1976).…”

Section: Potency Ratios Between Isoprenaline and Theophyllinementioning

confidence: 99%

INFLUENCE OF TRACHEAL CONTRACTION ON RELAXANT EFFECTS in vitro OF THEOPHYLLINE AND ISOPRENALINE

Karlsson

Persson

1981

British J Pharmacology

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1 Relaxation by (-)-isoprenaline (Iso) and theophylline (Theo) was measured in guinea-pig isolated trachea, in the presence or absence of carbachol. 2 With basal tone or with carbachol at a concentration of 5.4 x 10-7 M, causing 70% maximal contraction, Iso and Theo relaxed the trachea to the same extent. 3 With carbachol concentrations of 5.4 x 10-6M and 5.4 x 10-5M (96% and 100% maximal contractions) Iso caused no more than 63% and 34%, respectively, of the maximum relaxation to Theo. 4 When calculated at 25% of the maximum Theo relaxation, the Iso/Theo potency ratio was gradually reduced from 14,160 when evaluated at basal tone to 1,560 at the highest carbachol concentration. 5 In combination, at their maximally effective concentrations, Theo and Iso produced no larger a relaxation than did Theo alone. 6 At the two highest concentrations of carbachol, concentration-response curves to Theo were virtually superimposable whether determined in the absence or the presence of Iso at its maximally effective concentration. 7 It is concluded that Theo causes a greater relaxation of highly contracted tracheal muscle than Iso.

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Section: Potency Ratios Between Isoprenaline and Theophyllinementioning

confidence: 99%

INFLUENCE OF TRACHEAL CONTRACTION ON RELAXANT EFFECTS in vitro OF THEOPHYLLINE AND ISOPRENALINE

Karlsson

Persson

1981

British J Pharmacology

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“…Numerous studies [4, 9, 10, 11, 12, 14, 15]have failed to show a relationship between absolute change in FEV 1 after bronchodilation and initial FEV 1 . Some authors [16, 17, 18, 19, 20]found a relationship between absolute changes in FEV 1 and initial FEV 1 . However, whether this relationship persisted when initial FEV 1 was expressed as percentage of predicted values has not been verified.…”

Section: Discussionmentioning

confidence: 99%

Influence of Predicted FEV<sub>1</sub> on Bronchodilator Response in Asthmatic Patients

Ouksel

Meslier²,

Badatcheff-Coat³

et al. 2003

Respiration

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Background: There is currently disagreement on the way of expressing the reversibility of airflow obstruction, with some evaluations based on the initial FEV₁ while others use predicted FEV₁ (according to age, gender and height). Objectives: To test the relevance of expressing bronchodilator response as a percentage of predicted FEV₁, we evaluated the influence of morphological data on the response to bronchodilators in a population with a large range of predicted values. Methods: We measured the change in FEV₁ after inhalation of 200 µg of salbutamol in 30 asthmatic subjects (15 adults and 15 children) in whom predicted FEV₁ ranged between 1.13 and 4.10 liters and analyzed the respective influence of initial and predicted FEV₁on bronchodilator response. Results: We have shown a significant relationship between the absolute variation in FEV₁, in liters, and predicted FEV₁ (p = 0.0019). There was also a significant relationship between the absolute variation in FEV₁ and initial FEV₁, in liters (p = 0.02). This relationship was no longer significant (p = 0.8) when the variation and initial FEV₁ were both expressed as percentages of predicted FEV₁. In addition, multiple regression analysis showed that predicted FEV₁ was the only independent variable correlating with the response to bronchodilators. Conclusion: This study showed the influence of predicted FEV₁ on bronchodilator response. This result provides an additional argument for expressing bronchodilator response as a percentage of predicted FEV₁.

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“…A number of studies have shown the valuable efficacy of anti-cholinergic drugs on dilating large airways in asth matic patients [Crompton, 1968;Chick and Jenne, 1977], although the whole bronchodilating action appears to be less than that of beta2-agonist drugs. How ever, the combination of ipratropium bromide and metaproterenol resulted in an additional bronchodilator effect that was significantly greater and longer than that of ipratropium bromide or metapro terenol when given alone, in allergic asth matic patients [Bruderman et al, 1983].…”

Section: Discussionmentioning

confidence: 99%

Acute on Chronic Comparative Effects of a Combination of Fenoterol-Ipratropium Bromide and Terbutaline in Patients with Chronic Obstructive Lung Disease

Grassi¹,

Bruni²,

Peccini³

et al. 1986

Respiration

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Twenty patients suffering from chronic obstructive lung disease (COLD) were examined in a randomized intra-individual single-blind study in order to compare the ventilatory response, tolerance and side-effects of a combination of 40 µg ipratropium bromide and 100 µg fenoterol (Duovent) with 250 µg terbutaline, both given by inhalation (2 puffs) three times a day. The ventilatory parameters FVC, FEV₁, sGaw, RV and PaO₂, tested on the 7th and 14th days at 0, 30, and 240 min after the morning administration of the two drugs, showed significant differences between treatments, revealing a greater persistence of bronchodilator effect and a more prolonged duration of action with Duovent than with terbutaline. We believe that the results obtained suggest the usefulness of a combination of anti-cholinergic and beta₂-agonist drugs in the treatment of reversible bronchial obstruction in COLD, where even the parasympathetic nervous system seems to play an important role. The observed clinico-functional effects (intensity and duration of bronchodilatation) together with the lack of side-effects permit us to affirm that Duovent is a rational pharmacologic combination which represents real progress in the difficult treatment of COLD patients

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A comparison of responses to bronchodilator drugs in chronic bronchitis and chronic asthma

Cited by 57 publications

References 14 publications

INFLUENCE OF TRACHEAL CONTRACTION ON RELAXANT EFFECTS in vitro OF THEOPHYLLINE AND ISOPRENALINE

INFLUENCE OF TRACHEAL CONTRACTION ON RELAXANT EFFECTS in vitro OF THEOPHYLLINE AND ISOPRENALINE

Influence of Predicted FEV<sub>1</sub> on Bronchodilator Response in Asthmatic Patients

Acute on Chronic Comparative Effects of a Combination of Fenoterol-Ipratropium Bromide and Terbutaline in Patients with Chronic Obstructive Lung Disease

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