A Comparison of Reproductive Hormones and Biochemical Parameters in Hypothyroid and Euthyroid Postmenopausal Women

Dalal, Deepika; Dahiya, Kiran; Malhotra, Vani; Aggarwal, Sameer; Malik, Ashish Kumar; Ahlawat, Ravinder

doi:10.7754/clin.lab.2020.200243

Cited by 4 publications

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“…Previous studies have demonstrated that postmenopausal women with hypothyroidism or subclinical hypothyroidism suffer adverse effects on lipid metabolism and consequent development of cardiovascular diseases [ 11 ]. Nevertheless, for postmenopausal women with thyroid dysfunction, it is unclear whether the use of MHT has favorable effects on lipid and glucose regulation.…”

Section: Introductionmentioning

confidence: 99%

Clinical observation of menopause hormone therapy in postmenopausal women with euthyroid and mild subclinical hypothyroidism

Huang

et al. 2023

BMC Endocr Disord

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Background To evaluate the endocrine hormone and metabolic indices in postmenopausal women with euthyroid and mild subclinical hypothyroidism after menopause hormone therapy (MHT). Methods A retrospective study of 587 postmenopausal women receiving MHT was conducted. Median (25–75th percentile) age was 52 (49–54) years. According to thyroid stimulating hormone (TSH) levels at initial diagnosis, the patients were divided into three groups: I (euthyroid with low normal TSH range, n = 460), II (euthyroid with upper normal TSH range, n = 106) and III (mild subclinical hypothyroidism, n = 21). After a continuous oral MHT regimen using the same estradiol potency for 6–18 month cycles, serum endocrine hormone and metabolic indices were reassessed. Results Compared with baseline, serum TSH levels in groups I and II significantly changed but all values were within the normal range. No significant difference was observed in serum TSH levels in group III. After treatment, all serum free tri-iodothyronine and free thyroxine levels were within the normal range. Serum total cholesterol, triglyceride, fasting plasma glucose, fasting insulin levels and homeostasis model assessment of insulin resistance index had significantly decreased in group I. There were no significant differences in all observed lipid and glucose parameters in group III, before and after treatment. Conclusion MHT did not affect thyroid function in postmenopausal women with euthyroid and mild subclinical hypothyroidism. MHT led to an improvement in lipid and glucose indicators in euthyroid women with low normal TSH range.

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Section: Introductionmentioning

confidence: 99%

Clinical observation of menopause hormone therapy in postmenopausal women with euthyroid and mild subclinical hypothyroidism

Huang

et al. 2023

BMC Endocr Disord

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“…The important reason for this phenomenon may be sex hormones the incidence of hypercholesterolemia in females was significantly higher than that in males (58.00% vs 44.00%). The possible reason might be that estrogen can inhibit the activities of hepatic lipase and lipoprotein lipase by increasing the expression of SREBP2 (SREBP2 is a key transcription factor regulating cholesterol metabolism) in hepatocytes ( 24 , 25 ), that leads to increase in cholesterol levels in female. Compared with female patients, male patients had a higher incidence of hypertriglyceridemia (64.00% vs 44.00%).…”

Section: Discussionmentioning

confidence: 99%

The relationships between thyroid functions of short-term rapid hypothyroidism and blood lipid levels in post-thyroidectomy patients of differentiated thyroid cancer

Yao¹,

Zhao²,

Liu³

et al. 2023

Front. Endocrinol.

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ObjectiveTo explore the relationship between short-term rapid hypothyroidism and blood lipid levels in patients with differentiated thyroid cancer (DTC).MethodsSeventy-five DTC patients scheduled to receive radioactive iodine ablation were enrolled. Levels of thyroid hormone and serum lipids were tested at two time points: the euthyroid before thyroidectomy, and the hypothyroid (off thyroxine). Then the collected data were analyzed.ResultsTotally 75 DTC patients enrolled, among them, 5o were female (66.67%) and 25 were male (33. 33%), with an average age of 52.24 ± 1.24 years old. The short-term rapid severe hypothyroidism induced by thyroid hormone withdrawal significantly aggravated dyslipidemia, particularly in patients with dyslipidemia before thyroidectomy (All P < 0.01). However, there was no significant differences between blood lipid levels with different thyroid stimulating hormone (TSH) levels. And our study showed significant negative correlations between free triiodothyronine levels and the changes from euthyjroidism to hypothyroidism in total cholesterol (r=-0.31, P=0.03), triglycerides (r=-0.39, P=0.006), high density lipoprotein-cholesterol (HDL-C) (r=-0.29, P=0.042), and significant positive correlations between free thyroxine and the changes of HDL-C (r=-0.32, P=0.027) were identified in females, however, which were not observed in males.ConclusionShort-term rapids severe hypothyroidism caused by thyroid hormone withdrawal can lead to rapid significant changes in blood lipid levels. It is necessary to pay attention to dyslipidemia and its long-term effects after thyroid hormone withdrawal, especially in patients with dyslipidemia before thyroidectomy. Clinical trial registrationhttps://clinicaltrials.gov/ct2/show/NCT03006289?term=NCT03006289&draw=2&rank=1, identifier NCT03006289.

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“…In this study, we observed that a significant risk factor for severe CS was a history of chronic stress and anxiety. In perimenopause, women have a decrease in estradiol and an increase in gonadotropic hormones, the importance of which in the development of CS is beyond doubt [ 9 ], which may be accompanied by an increase in depression and anxiety [ 10 , 11 ] in menopausal women. Some studies confirm the relationship between the presence of a history of chronic stress and severe clinical manifestations of CS [ 11 , 12 ].…”

Section: Discussionmentioning

confidence: 99%

Prediction of climacteric syndrome development in perimenopausal women with hypothyroidism

Chukur¹,

Pasyechko²,

Bob³

et al. 2022

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Introduction The study aim was to predict the risk of climacteric syndrome (CS) developing in perimenopausal women with hypothyroidism (HT) according to the developed algorithm and mathematical model for timely preventive measures. Material and methods 146 perimenopausal women with autoimmune HT were enrolled in this study. Assessment of the severity of metabolic, neurovegetative and psychoemotional symptoms was graded according to the Blatt-Kupperman menopause index. All women were interviewed according to a specially designed questionnaire for predicting the development of severe CS. Multiple regression analysis was used to build a multifactorial mathematical model. Shapiro-Wilk and Kolmogorov-Smirnov criteria were used to assess the normality of the distribution of traits. Results Regression analysis was used to determine the most significant multicollinear risk factors for CS developing: pathology of the thyroid gland, smoking, alcohol consumption, adverse environmental conditions, low physical activity, history of stress and anxiety. The predicted value of the risk factor for severe CS with a high degree of probability was determined in 72 (49.32%) women, medium probability in 58 (39.73%) women, and low probability in 16 (10.95%) women. Conclusions The developed algorithm and mathematical model are informative and allow one to prevent CS and its complications. The decay of women’s health starts many years before menopause and prevention of its consequences is an important task for the clinicians.

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A Comparison of Reproductive Hormones and Biochemical Parameters in Hypothyroid and Euthyroid Postmenopausal Women

Cited by 4 publications

References 0 publications

Clinical observation of menopause hormone therapy in postmenopausal women with euthyroid and mild subclinical hypothyroidism

Clinical observation of menopause hormone therapy in postmenopausal women with euthyroid and mild subclinical hypothyroidism

The relationships between thyroid functions of short-term rapid hypothyroidism and blood lipid levels in post-thyroidectomy patients of differentiated thyroid cancer

Prediction of climacteric syndrome development in perimenopausal women with hypothyroidism

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