A comparison of pulp responses to two different materials in the dog and the rat

Watts, A.; Paterson, Robert C.

doi:10.1016/0030-4220(81)90085-2

Cited by 18 publications

(17 citation statements)

References 18 publications

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“…Several other studies on direct pulp capping using rats have reported complete dentin bridge formation by Ca(OH) 2 -based materials after 4 weeks. [28][29][30] The greater induction of hard tissue formation by Poly-CaP, similar to Dycal, compared with HAp, is considered to be attributable to its Ca-releasing property. It is well known that Ca 2+ ions have promotive effects on cells associated with hard tissue formation.…”

Section: Discussionmentioning

confidence: 97%

Efficacy of polyphasic calcium phosphates as a direct pulp capping material

Kiba

Imazato

Takahashi

et al. 2010

Journal of Dentistry

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Section: Discussionmentioning

confidence: 97%

Efficacy of polyphasic calcium phosphates as a direct pulp capping material

Kiba

Imazato

Takahashi

et al. 2010

Journal of Dentistry

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“…25,26,29,[31][32][33][34][43][44][45][46] Although raised many years ago, 47 the concern about different pulp responses which originated from different animal species has only recently been acknowledged as a way of explaining the controversial data. 48 Well-resolved direct pulp capping with adhesive systems are generally reported using monkeys or rats.…”

Section: Discussionmentioning

confidence: 99%

Pulpal responses following direct pulp capping of healthy dog teeth with dentine adhesive systems

Koliniotou-Koumpia

Tziafas

2005

Journal of Dentistry

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“…However, only 60% of molar teeth in dogs showed hard tissue formation after six weeks. 25 In addition, the authors 25 referred to a study by Nyborg,…”

Section: Animal Models For Pulp Capping Studiesmentioning

confidence: 99%

“…Box indicates the first upper molar tooth (see Figure 2). Bar represents 3 mm, original magnification Â2 25 study. All this may lead to the conclusion that the results of studies concerning direct pulp capping conducted in rat molar teeth are better comparable with humans than the results obtained from experiments in dogs.…”

mentioning

confidence: 99%

Rat molar teeth as a study model for direct pulp capping research in dentistry

Dammaschke

2010

Lab Anim

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The aim of this review is to evaluate the suitability of rat molar teeth in preclinical evaluation of medical devices for direct pulp capping. The ISO standard 7405 states clearly that only non-rodent mammals are suitable species for animal research in dentistry. Furthermore, without clear justification a considerable number of researchers previously rejected results of animal experiments concerning preclinical evaluation of the biocompatibility of dental materials undertaken in rat molar teeth. However, in the past 50 years about 70 studies have been published using rat molar teeth in order to evaluate direct pulp capping, pulpotomies and tissue reactions after pulp exposure. Numerous studies showed that the healing of rat molar pulp tissue after direct pulp capping is histologically comparable with humans and other animal species pulp tissue. Rat molar teeth, including pulp tissue, can be seen anatomically, histologically, biologically, and physiologically as miniature human molar teeth. Hence, the essential biological reactions of the pulp tissue and the interaction during the different stages of wound healing of rat molar teeth are comparable with that of other mammals. Rat molar teeth are a valid study model in order to provide valuable data concerning pulp tissue reaction after direct pulp capping and related questions in dentistry. Therefore, the use of rats may significantly reduce the number of currently used higher animals in research. Tests in higher developed animals should be limited to experiments which clarify inconsistent results. However, some technical difficulties, like the small size of rat molar teeth must be dealt with before undertaking any research.

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A comparison of pulp responses to two different materials in the dog and the rat

Cited by 18 publications

References 18 publications

Efficacy of polyphasic calcium phosphates as a direct pulp capping material

Efficacy of polyphasic calcium phosphates as a direct pulp capping material

Pulpal responses following direct pulp capping of healthy dog teeth with dentine adhesive systems

Rat molar teeth as a study model for direct pulp capping research in dentistry

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