A comparison of pre-emptive analgesic efficacy of diflunisal and lornoxicam for postoperative pain management: a prospective, randomized, single-blind, crossover study

Pektas, Zafer Ozgur; Şener, Mesut; Bayram, Burak; Eroğlu, Tamer; Bozdogan, Nesrin; Dönmez, Aslı; Arslan, G.; Uçkan, Sina

doi:10.1016/j.ijom.2006.10.005

Cited by 26 publications

(19 citation statements)

References 23 publications

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“…Most serious side effects occur only after long-term use [4] . In the study by Pektas et al [34] , none of the patients in the lornoxicam and diflunisal groups recorded allergy, nausea and vomiting or other gastrointestinal side effects.…”

Section: Discussionmentioning

confidence: 91%

Postoperative Analgesia in Impacted Third Molar Surgery: The Role of Preoperative Diclofenac Sodium, Paracetamol and Lornoxicam

Oncul

Yazicioglu²,

Alanoğlu³

et al. 2011

Med Princ Pract

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Objective: The aim of this study was to compare the postoperative analgesic effects of preoperative intravenous (i.v.) paracetamol, diclofenac sodium and lornoxicam (nonsteroidal anti-inflammatory drugs). Subjects and Methods: Sixty patients with impacted third molar who underwent surgical removal were randomly allocated into three groups: group P (n = 20), group D (n = 20) and group L (n = 20). Group P received preoperatively 1 g paracetamol i.v., group D 75 mg diclofenac sodium i.m. and group L 8 mg lornoxicam i.v. Postoperative pain intensity, additional consumption of analgesics postoperatively and postoperative complications were compared among groups. Results: The groups were comparable for pain scores (p > 0.05). Maximum pain scores were recorded in postoperative 4th h in all groups (group L 22, 14–44 mm; group P 24, 13–43 mm; group D 14, 10–24 mm, p = 0.117). Patients experienced high satisfaction scores which were comparable among groups (group L 85, 75–100 mm; group P 87, 70–95 mm; group D 84, 77–98 mm, p = 0.457). Conclusion: Preoperative intramuscular diclofenac, intravenous paracetamol and lornoxicam effectively decreased the pain scores. The patients were satisfied with the three postoperative pain management regimens.

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Section: Discussionmentioning

confidence: 91%

Postoperative Analgesia in Impacted Third Molar Surgery: The Role of Preoperative Diclofenac Sodium, Paracetamol and Lornoxicam

Oncul

Yazicioglu²,

Alanoğlu³

et al. 2011

Med Princ Pract

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“…Meechan and Seymour 28 have studied different complications that appear after impacted third molar surgery and have concluded that the observation of such complications is important to comparatively evaluate the efficacy of several therapeutic measures. Other authors have shown that surgical procedure and immediate postoperative observations are a clinical model for the evaluation of the efficacy of different drugs 14,18,29,30 . In the crossover model used in our study, the same patient was submitted to both proposed treatments (submucosal injection and oral route), one for each operated side during randomization.…”

Section: Discussionmentioning

confidence: 99%

Evaluation of effects of two dexamethasone formulations in impacted third molar surgeries

et al. 2014

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BACKGROUND AND OBJECTIVES:Submucosal dexamethasone injection directly in the surgical area has been used in different dental procedures, but there are still few studies evaluating its efficacy as compared to oral route for impacted third molar surgeries. So, this study aimed to evaluate postoperative pain, edema and trismus after impacted third molar surgeries using oral or submucosal local injection of dexamethasone. METHODS:This was a prospective, controlled, crossover and randomized study involving 36 patients with indication of lower third molar surgeries, who were randomly distributed in two groups: group A -submucosal local injection of dexamethasone (4mg/1mL) after local anesthesia, and group B -oral dexamethasone tablet (4mg) one hour before procedure. Edema and trismus were clinically evaluated in the postoperative period and in the 1 st , 2 nd , 3 rd and 7 th postoperative days. Patients were oriented to record pain intensity in the visual analog scale in periods zero (preoperative), 1h, 2h, 4h, 12h, 1 day, 2 days and 3 days and one week after surgery. Data were submitted to statistical analysis with significance level of 5%. RESULTS: There were no significant differences in surgical time with regard to operated sides (p=0.4). Edema and trismus values were not statistically different between observed groups (p>0.05). Mean pain values recorded in the visual analog scale were not statistically different between groups and patients have Evaluation of effects of two dexamethasone formulations in impacted third molar surgeries* Avaliação dos efeitos de duas formulações de dexametasona em cirurgias de terceiros molares inclusos

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“…19,23 A single large dose or a short duration of therapy causes fewer adverse effects, and preoperative medication with NSAIDs or steroids has been suggested to have favourable effects. [24][25][26][27][28] However, if glucocorticoid therapy is prescribed for more than one week, some signs of steroid toxicity may emerge. Also, the development of common NSAID side effects associated with cyclooxygenase enzyme systems may manifest as adverse gastrointestinal outcomes, including ulceration and negative influences on renal function.…”

Section: Discussionmentioning

confidence: 99%

“…19,23 A single large dose or a short duration of steroid therapy causes few adverse effects for most patients, and preoperative medication with NSAIDs or steroids can have favourable effects. [24][25][26][27][28] This study examined the effect of a single administration of a preoperative oral steroid on postoperative symptoms in 462 ª 2010 Australian Dental Association…”

Section: Introductionmentioning

confidence: 99%

Effect of preoperative prednisolone on clinical postoperative symptoms after surgical extractions of mandibular third molars

Kang

Choi²,

Iy³

et al. 2010

Australian Dental Journal

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Background: This study compared postoperative symptoms in patients treated preoperatively with a single dose of £20 mg oral steroid during third molar surgery. Methods: A total of 450 patients were categorized randomly into three groups containing 150 patients each. Patients were in their second or third decade and had no specific medical history and findings involving infections of the mandibular third molar area. Two groups received preoperative steroids orally one hour before the operation; one group received 10 mg prednisolone and the other received 20 mg. No steroids were administered to the control group. Patients were asked to report by questionnaire any changes in postoperative symptoms, such as pain, facial oedema, or gastrointestinal disorders, and in masticatory disorders, trismus, or swallowing discomfort. They reported daily from days 1 to 6 post-extraction by evaluating their experience over the preceding 24 hours. Results: A single preoperative oral administration of £20 mg prednisolone had no significant effect on postoperative symptoms of pain, facial oedema, or gastrointestinal upset, or on masticatory symptoms, trismus, or swallowing discomfort in mandibular third molar surgery. Conclusions: A single oral dose of £20 mg prednisolone before third molar extraction may not be helpful for the relief of postoperative symptoms.

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A comparison of pre-emptive analgesic efficacy of diflunisal and lornoxicam for postoperative pain management: a prospective, randomized, single-blind, crossover study

Cited by 26 publications

References 23 publications

Postoperative Analgesia in Impacted Third Molar Surgery: The Role of Preoperative Diclofenac Sodium, Paracetamol and Lornoxicam

Postoperative Analgesia in Impacted Third Molar Surgery: The Role of Preoperative Diclofenac Sodium, Paracetamol and Lornoxicam

Evaluation of effects of two dexamethasone formulations in impacted third molar surgeries

Effect of preoperative prednisolone on clinical postoperative symptoms after surgical extractions of mandibular third molars

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