A comparison of lens parameters in patients with various subtypes of primary angle-closure disease and the normal population: A prospective study

Samant, Swati; Chakrabarti, Keya; Mohapatra, Ramesh Chandra; Mishra, Suchismita; Das, Suprava; Chakrabarti, Meena

doi:10.4103/ijo.ijo_3007_21

Cited by 3 publications

(2 citation statements)

References 33 publications

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“…[20] In a study by Chakrabarti et al, different lens parameters were analyzed, and the mean lens thickness was more in all subtypes of angle closure disease (4.24 ± 0.84 to 5.02 ± 0.18 mm) compared to the control group (4.04 ± 0.46 mm) and was statistically signi cant (P < 0.01). [21] These ndings were similar to that of our study. It was also observed that there was a direct correlation between increasing age and lens thickness, which again correlated directly with a shallowing of the anterior chamber.…”

Section: Discussionsupporting

confidence: 92%

Comparison of choroidal thickness and lens thickness among subtypes of angle closure disease

Yeluguri,

Thulasidas,

Sasidharan

et al. 2024

Preprint

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Purpose: To evaluate choroidal thickness and lens thickness among various subtypes of angle closure disease and compare it with healthy controls Methods: This observational comparative study was conducted between June 2022 and February 2023 at our eye hospital, including eyes with subtypes of angle closure disease and healthy controls. Lens thickness was measured using an automated optical biometer, and choroidal thickness was measured using enhanced depth imaging spectral-domain optical coherence tomography in the subtypes of angle closure disease and healthy control subjects. Results: One hundred and twenty-four eyes were enrolled, including 93 angle closure disease eyes and 31 healthy eyes. The mean choroidal thickness was significantly higher in angle closure subtypes than healthy controls (247.19 ± 40.97 µm, 318.81 ± 24.81 µm, 383.81 ± 53.06 µm, 173.65 ± 28.19 µm in primary angle closure suspect, primary angle closure, primary angle closure glaucoma, and healthy controls, respectively (P < 0.001)). The mean lens thickness was higher in angle closure disease compared to the control group (P < 0.01). Conclusion: Increased choroidal thickness might be another anatomic characteristic of primary angle closure eyes along with increased lens thickness. This finding may support the hypothesis that choroidal enlargement plays a part in the development of primary angle closure disease. Trial registration number: CTRI/2022/08/044903

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Section: Discussionsupporting

confidence: 92%

Comparison of choroidal thickness and lens thickness among subtypes of angle closure disease

Yeluguri,

Thulasidas,

Sasidharan

et al. 2024

Preprint

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“…AS-OCT also has the advantage of a longer scan depth, which allows the visualization of the lens. Thicker lenses with greater lens vaults were found to be important anatomical features in angle-closure eyes by AS-OCT, revealing the crucial role of the lens in the pathogenesis of angle-closure disease [38][39] . Other factors associated with narrow ACA found by UBM and AS-OCT include increased iris thickness, greater iris curvature, larger iris area, and iris volume [40][41][42] .…”

Section: Discussionmentioning

confidence: 96%

Publication trends of primary angle-closure disease during 1991-2022: a bibliometric analysis

Huang¹,

Wang²,

Sun³

2023

Int J Ophthalmol

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AIM: To perform a bibliometric analysis in the field of primary angle-closure disease (PACD) research to characterize current global trends and compare contributions from different countries, institutions, journals, and authors. METHODS: All PACD-related publications from 1991 to 2022 from the Web of Science Core Collection database were extracted. Microsoft Excel and VOSviewer were used to collect publication data, analyze publication trends, and visualize relevant results. RESULTS: A total of 1721 publications with 34 591 citations were identified. China produced the most publications (554) while ranking third in citations (8220 times). The United States contributed the most citations (12 315 times) with publications (362) ranking second. The Investigative Ophthalmology Visual Science was the most productive journal concerning PACD, and Aung Tin was the author with the highest number of publications in the field. Keywords were classified into three clusters, epidemiology and pathogenesis research, optical coherence tomography (OCT) and other imaging examinations, and glaucoma surgery treatment. Genome-wide association, susceptibility loci, OCT, and combined phacoemulsification have become new hot research topics in recent years since 2015. CONCLUSION: China, the United States, and Singapore make the most outstanding contributions in the field of PACD research. OCT, combined phacoemulsification, and gene mutation-related study, are considered the potential focus for future research.

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The Mirror Theory: Parallels between Open Angle and Angle Closure Glaucoma

Potop,

Dragosloveanu,

Ciocâlteu

et al. 2024

Life

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Glaucoma is a widespread ophthalmological disease, with a high impact and frequent visual morbidity. While the physiopathology of the two types of primary glaucoma (open angle and angle closure) has been studied, there seems to be little relationship between the two. In this study, we gather clinical and preclinical data to support the idea that the two primary glaucomas are “mirrored” in terms of morphological parameters and disease physiopathology. In short, primary angle closure glaucoma (PACG) is associated with hyperopia and low axial length, and primary open angle glaucoma (POAG) is associated with myopia and high axial length. Moreover, in PACG and in primary angle closure or primary angle closure suspect cases, while there is extensive iridotrabecular contact, the intraocular pressure (IOP) is still maintained in the lower half of the normal range throughout the evolution of the disease, which suggests a baseline trabecular hyperfiltration in PACG. In the opposite case, myopic eyes with open angles and a higher risk of developing POAG often have a baseline IOP in the upper half of the normal range, suggesting a baseline trabecular hypofiltration. As we explore clinical, genetic and animal model data regarding these opposing aspects, we hypothesize the existence of a mirroring relationship between PACG and POAG. Defining the relationship between the two potentially blinding diseases, with a high prevalence worldwide, may aid in understanding the mechanisms better and refining diagnosis and treatment. Thus, our theory has been named the Mirror Theory of Primary Glaucomas.

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A comparison of lens parameters in patients with various subtypes of primary angle-closure disease and the normal population: A prospective study

Cited by 3 publications

References 33 publications

Comparison of choroidal thickness and lens thickness among subtypes of angle closure disease

Comparison of choroidal thickness and lens thickness among subtypes of angle closure disease

Publication trends of primary angle-closure disease during 1991-2022: a bibliometric analysis

The Mirror Theory: Parallels between Open Angle and Angle Closure Glaucoma

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