Comparison of choroidal thickness and lens thickness among subtypes of angle closure disease

Abstract

Purpose: To evaluate choroidal thickness and lens thickness among various subtypes of angle closure disease and compare it with healthy controls Methods: This observational comparative study was conducted between June 2022 and February 2023 at our eye hospital, including eyes with subtypes of angle closure disease and healthy controls. Lens thickness was measured using an automated optical biometer, and choroidal thickness was measured using enhanced depth imaging spectral-domain optical coherence tomography in the subtypes of angle closure disease and healthy control subjects. Results: One hundred and twenty-four eyes were enrolled, including 93 angle closure disease eyes and 31 healthy eyes. The mean choroidal thickness was significantly higher in angle closure subtypes than healthy controls (247.19 ± 40.97 µm, 318.81 ± 24.81 µm, 383.81 ± 53.06 µm, 173.65 ± 28.19 µm in primary angle closure suspect, primary angle closure, primary angle closure glaucoma, and healthy controls, respectively (P < 0.001)). The mean lens thickness was higher in angle closure disease compared to the control group (P < 0.01). Conclusion: Increased choroidal thickness might be another anatomic characteristic of primary angle closure eyes along with increased lens thickness. This finding may support the hypothesis that choroidal enlargement plays a part in the development of primary angle closure disease. Trial registration number: CTRI/2022/08/044903