2003
DOI: 10.1016/s0168-8227(02)00202-4
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A comparison of insulin lispro Mix25™ and human insulin 30/70 in the treatment of type 2 diabetes during Ramadan

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Cited by 78 publications
(53 citation statements)
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“…Moreover, many will need an additional dose of short-acting insulin at predawn. There is some evidence suggesting that use of insulin lispro instead of regular insulin before meals in patients with type 2 diabetes who fast during Ramadan is associated with less hypoglycemia and smaller postprandial glucose excursions (26,27). Again, as emphasized earlier, the overall dosage of medications, especially that of insulin, must be adjusted in conjunction with the weight loss or gain that may occur during Ramadan.…”
Section: Management Of Patients With Type 2 Diabetesmentioning
confidence: 98%
“…Moreover, many will need an additional dose of short-acting insulin at predawn. There is some evidence suggesting that use of insulin lispro instead of regular insulin before meals in patients with type 2 diabetes who fast during Ramadan is associated with less hypoglycemia and smaller postprandial glucose excursions (26,27). Again, as emphasized earlier, the overall dosage of medications, especially that of insulin, must be adjusted in conjunction with the weight loss or gain that may occur during Ramadan.…”
Section: Management Of Patients With Type 2 Diabetesmentioning
confidence: 98%
“…A comparison of insulin lispro Mix25 (25% short-acting lispro/75% intermediate-acting lispro protamine) with human insulin 30/70 (30% short-acting soluble human insulin/70% intermediate-acting neutral protamine Hagedorn [NPH]) during Ramadan found that overall glycaemia was significantly lower for patients on insulin lispro Mix25 (p = 0.004), with the greatest between-treatment difference evident before and after iftar [54]. Similarly, in another study insulin lispro Mix50 (50% lispro/50% lispro protamine) in the evening and regular human insulin with NPH (30:70) in the morning improved glycaemic control without increasing the incidence of hypoglycaemic events compared with regular human insulin with NPH (30:70) given twice daily [55].…”
Section: Insulin Treatment For T2dmmentioning
confidence: 99%
“…• Insulin aspart 70/30 versus NPH/regular 70/30-3 parallel-arm trials 31,33,34 and 3 crossover trials [35][36][37] • Insulin lispro 75/25 versus NPH/regular 70/30 or NPH/regular 50/50-9 randomized crossover studies [37][38][39][40][41][42][43][44][45] and 1 retrospective observational study 28 • Insulin lispro 50/50 versus NPH/regular 70/30 or NPH/ regular 50/50-3 randomized crossover studies 38,41,46 and 1 parallel-arm study 47 The studies varied considerably in therapy administration methods, dosing schedules, and duration.…”
Section: Premixed Insulin Analogues Versus Premixed Human Insulinmentioning
confidence: 99%