A Comparison of hs-CRP Levels in New Diabetes Groups Diagnosed Based on FPG, 2-hPG, or HbA1c Criteria

Tütüncü, Yıldız; Satman, İlhan; Çelik, Selda; Dınççağ, Nevin; Karşıdağ, Kubilay; Telci, Ayşegül; Genç, Sema Yılmaz; İşsever, Halim; Tuomilehto, Jaakko; Ömer, Beyhan

doi:10.1155/2016/5827041

Cited by 32 publications

(29 citation statements)

References 34 publications

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“…This is because higher systemic subinflammation and central obesity is highly associated with body mass index and waist circumference which is found mostly at the age of forty years and concise with the likely age of onset of type 2 diabetes. This study is in agreement with the work of Svensson et al, [26] and Tutuncu et al, [27] that reported higher C-reactive protein among people at age of onset due to obesity and accumulation of free fatty acids. Also, Cardoso et al, [28] showed higher CRP which was significantly associated with younger age less than eighty years.…”

Section: Discussionsupporting

confidence: 94%

Studies on Acute Phase Inflamatory Proteins of Type 2 Diabetics in Owerri

C¹,

U²,

C³

2019

SJBR

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Type 2 diabetes mellitus is a chronic metabolic disorder which has emerged as a health challenge globally due to its insidious on set, late recognition and complications. The present study was aimed at evaluation of acute phase inflammatory proteins in Owerri. Cross Sectional Studies was conducted at Federal Medical Center and Imo State specialist Hospital, Owerri. A total of three hundred subjects which include each one hundred and fifty type 2 diabetics and apparently control subjects between the ages forty and sixty nine years were recruited. Ten millimeters of venous blood was aseptically collected from the subjects. Spectrophotometric, nephlometric, enzyme immunoassay were used for determination of these parameters. The data was analyzed using statistical package for social science 20.0. Test with a probability value of P<0.05 was considered statistically significant. Result from acute phase inflammatory proteins showed that the mean value of c-reactive protein alpha 1-acid glycoprotein, alpha1-antitrypsin, haptoglobin and ceruloplasmin in type 2 diabetics (5.21± 0.91mg/l, 99.34±17.84mg/dl, 152.32 ± 26.69, 154.03±7.75mg/dl, 47.83 ± 6.20mg/dl) were higher which was statistically significant (P=0.001) when compared with the control subjects (3.14± 0.80mg/l,76.86 ± 12.41mg/dl, 114.94±16.11mg/dl, 132.80 ± 79mg/dl, 34.47 ± 3.75mg/dl). There was statistically significant progressive decrease (P=0.04) in c-reactive protein (5.50 ± 0.98, 5.08 ± 0.84, 5.0 4± 0.83mg/l );significant increase (P =0.001) in haptoglobin (149.40 ± 7.78, 155.96 ± 7.93, 157.84 ± 6.12mg/dl) and ceruloplasmin (45.54 ± 6.84, 46.92 ± 5.79, 51.44 ± 6.12mg/dl).The mean value alpha1-acid glycoprotein in female type 2 diabetics was statistically significantly higher (P=0.001) when compared to male (10.912± 17.29 v 89.55± 0.19mg/dl) .

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Section: Discussionsupporting

confidence: 94%

Studies on Acute Phase Inflamatory Proteins of Type 2 Diabetics in Owerri

C¹,

U²,

C³

2019

SJBR

View full text Add to dashboard Cite

show abstract

“…Finally, the present study found a high reliability for hs-CRP in diagnosis of diabetic patients. This finding is supported by the study of Tutuncu et al [38] who concluded that hs-CRP has good discriminative power in detection of newly diagnosed diabetes. Use of IL-18 in distinguishing DM is a novel finding by the present study.…”

Section: Discussionsupporting

confidence: 68%

Study of interleukin-18 ( IL18 ) and high sensitive C - reactive protein ( CRP ) in type 2 diabetes ( T2D ) with or without obesity

Kamel*

El-Baz

Emam

et al. 2020

Arab Journal of Nuclear Sciences and Applications

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Both diabetes and obesity are associated with chronic low-grade inflammation. IL-18 is a cytokine that stimulates various cell types and has pleiotropic functions. It is elevated in obesity, metabolic syndrome and type 2 diabetes (T2D).The hypothesis that serum level of IL-18 and high sensitive C-reactive protein can be used as markers for presence of chronic low-grade inflammation in type 2 diabetes more than in obesity per se was tested. The study recruited 80 subjects. They comprised 20 diabetic obese cases (DM-OB group), 20 diabetic non-obese cases (DM-NOB group), : 20 non-diabetic obese cases (NDM-OB group) and 20 non-diabetic non-obese subjects (NDM-NOB group). All participants were submitted to careful history taking, through clinical investigations and laboratory assessment. It was found that hs-CRP was significantly high in DMOB group (3.4±0.5 mg/dl) followed by NDM-OB group (2.9±0.4 mg/dl) then DM-NOB group (2.3±0.3 mg/dl) and least in NDM-NOB (0.8±0.3 mg/dl). It was also found that serum IL-18 was significantly highest in DMOB group (397.8±33.9 pg/mL) followed by NDM-OB (368.8±26.7 pg/mL) group followed by DM-NOB group (335.9±18.4 pg/mL) and least in NDM-NOB group (281.1±22.9 pg/mL). Serum IL-18 levels are directly correlated with BMI, waist circumference, hip circumference and waist/hip ratio in all the studied groups and with HbA1c in the diabetic groups. It could be concluded that Serum IL-18 and hs-CRP are related to diabetes and obesity. They are associated with dyslipidemia, poor glycemic control, insulin resistance and impaired liver and renal functions

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“…Sarinnapakorn et al showed that high HbA1c was associated with high HSCRP in obese diabetic women. (13). In our study , people with BMI more than 25 have different HSCRP pattern in compare to groups with BMI less than 25.In this group, along with higher HSCRP in high HbA1c level, people with low HbA1c has also high HSCRP which leads to U shape curve that is not demonstrated yet in latter studies.…”

Section: Discussioncontrasting

confidence: 48%

Relationship of serum VITD3, HSCRP and HbA1c level in non diabetic patients referring to tertiary hospital

Zare-Mirzaie¹,

Mehdizadeh²,

Babaheidarian³

2020

Preprint

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Background: In diabetic patients high HbA1c is associated with high level of HSCRP and VITD3 deficiency could result in diabetes and high HbA1c level. The aim of this study was to determine the relation of HbA1c, HSCRP and vitamin D3 in healthy individuals who referred to Rasool Akram Hospital. Methods: In this cross sectional study, individuals who referred to our center between 2018 and 2019 for the measurement of HbA1c were classified to three groups based on the level of the HbA1c: <5, 5-5.6 and 5.7≤. Then the Serum level of HSCRP and vitamin D3 were measured and compared between these three groups.Results: In this study, 90 healthy individuals were studied. In subjects with BMI below 25, no significant difference in HSCRP level was seen in group with low and normal HbA1c, but group with high HbA1c has non-significant higher level of HSCRP rather than group with normal HbA1c. In subject with BMI higher than 25, group with high HbA1c and low HbA1c had non-significant higher level of HSCRP than group with normal HbA1c and in the subjects, no significance difference at serum level of vitamin D3 level has been identified between HbA1c groups. Conclusion: As immunomedulatory role of VitD3 is shown in many studies and low VitD3 could predispose people to diabetes independent of obesity, Conflicting results in various studies emerge an idea to mind that considering relation of other factors responsible in glucose metabolism such as insulin level, IGF-1, C-Peptide and VitD3 could be a better overview on vitD3 effect on glucose metabolism

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A Comparison of hs-CRP Levels in New Diabetes Groups Diagnosed Based on FPG, 2-hPG, or HbA1c Criteria

Cited by 32 publications

References 34 publications

Studies on Acute Phase Inflamatory Proteins of Type 2 Diabetics in Owerri

Studies on Acute Phase Inflamatory Proteins of Type 2 Diabetics in Owerri

Study of interleukin-18 ( IL18 ) and high sensitive C - reactive protein ( CRP ) in type 2 diabetes ( T2D ) with or without obesity

Relationship of serum VITD3, HSCRP and HbA1c level in non diabetic patients referring to tertiary hospital

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