A comparison of hemolysis and red cell mechanical fragility in blood collected with different cell salvage suction devices

Yazer, Mark H.; Waters, Jonathan H.; Elkin, Kyle R.; Rohrbaugh, Max E.; Kameneva, Marina V.

doi:10.1111/j.1537-2995.2008.01670.x

Cited by 38 publications

(32 citation statements)

References 18 publications

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“…This seems not to be the case if blood is suctioned from containers (Waters et al, 2007). If suctioned from a flat surface the vacuum pressure does make a difference though it is very small (Yazer et al, 2008). 'Although the variable-pressure device produced a significant reduction in hemolysis during one-pass blood collection, the clinical significance of this reduction is not clear.…”

Section: Vacuum Type and Pressurementioning

confidence: 84%

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Transfusion Reduction in Orthopedic Surgery

Erve¹,

Wiekenkamp²

2012

Blood Transfusion in Clinical Practice

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Section: Vacuum Type and Pressurementioning

confidence: 84%

“…In another study Yazer et al also conclude that a higher level of airblood contact increases the level of hemolysis. They also found that hemolysis was decreased by using a vacuum suction device with variable pressure (Yazer et al, 2008).…”

Section: Washed Autologous Transfusionmentioning

confidence: 99%

Transfusion Reduction in Orthopedic Surgery

Erve¹,

Wiekenkamp²

2012

Blood Transfusion in Clinical Practice

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“…Hemolysis during cardiac surgery has previously been reported and is considered to be caused by cardiopulmonary bypass circuits, transfusion of stored red blood cells, and cell salvage devices. 8,[19][20][21] Interestingly, we found that the total release of plasma fHb was independently correlated with urine NAG, which in turn was independently associated with the postoperative increase in serum creatinine. This clinical observation is supported by rodent experiments in which intravenous infusion of fHb increased urine NAG concentrations 10-fold, while decreasing GFR by 30%.…”

Section: Discussionmentioning

confidence: 98%

Hemolysis is associated with acute kidney injury during major aortic surgery

Windsant

Snoeijs

Hanssen

et al. 2010

Kidney International

144

125

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Hemolysis is an inevitable side effect of cardiopulmonary bypass resulting in increased plasma free hemoglobin that may impair tissue perfusion by scavenging nitric oxide. Acute kidney injury after on-pump cardiovascular surgery arises from a number of causes and severely affects patient morbidity and mortality. Here, we studied the effect of acute hemolysis on renal injury in 35 patients undergoing on-pump surgical repair of thoracic and thoracoabdominal aortic aneurysms of whom 19 experienced acute kidney injury. During surgery, plasma free hemoglobin increased, as did urinary excretion of the tubular injury marker N-acetyl-beta-D-glucosaminidase, in patients with and without acute kidney injury, reaching peak levels at 2 h and 15 min, respectively, after reperfusion. Furthermore, plasma free hemoglobin was independently and significantly correlated with the urine biomarker, which, in turn, was independently and significantly associated with the later postoperative increase in serum creatinine. Importantly, peak plasma free hemoglobin and urine N-acetyl-beta-D-glucosaminidase concentrations had significant predictive value for postoperative acute kidney injury. Thus, we found an association between increased plasma free hemoglobin and renal injury casting new light on the pathophysiology of acute kidney injury. Therefore, free hemoglobin is a new therapeutic target to improve clinical outcome after on-pump cardiovascular surgery.

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“…For assessment of MF, we used the procedure described by Kameneva's group [33,34,35] with slight changes. 3 ml of RBC suspension (control, stored, and stored-rejuvenated) were rocked in glass test tubes (13 × 100 mm, Fisher Scientific), containing 5 steel beads (1/8-inch stainless-steel beads, Nationskander California Corp., Anaheim, CA, USA).…”

Section: Methodsmentioning

confidence: 99%

Storage-Induced Damage to Red Blood Cell Mechanical Properties Can Be Only Partially Reversed by Rejuvenation

Barshtein

Gural²,

Manny³

et al. 2014

Transfus Med Hemother

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Background: The storage of red blood cells (RBC) is associated with impairment of their properties that can induce a circulatory risk to recipients. In a preceding study (2009), we reported that post-storage rejuvenation (RJ) of stored RBC (St-RBC) efficiently reduced the storage-induced RBC/endothelial cell interaction, while only partially reversing the level of intracellular Ca²⁺, reactive oxygen species, and surface phosphatidylserine. In the present study, we examined the RJ effectiveness in repairing St-RBC mechanical properties. Methods: RBC, stored in CPDA-1 without pre-storage leukoreduction, were subjected to post-storage RJ, and the deformability, osmotic fragility (OF), and mechanical fragility (MF) of the rejuvenated St-RBC (St-RBC_Rj) were compared to those of untreated St-RBC and of freshly-collected RBC (F-RBC). Results: 5-week storage considerably increased OF and MF, and reduced the deformability of St-RBC. All alterations were only partially (40-70%) reversed by RJ, depending on the extent of the damage: the greater the damage, the lesser the relative effect of RJ. Conclusion: The findings of the present and preceding studies suggest that different St-RBC properties are differentially reversed by RJ, implying that some of the changes occur during storage and are irreversible.

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A comparison of hemolysis and red cell mechanical fragility in blood collected with different cell salvage suction devices

Cited by 38 publications

References 18 publications

Transfusion Reduction in Orthopedic Surgery

Transfusion Reduction in Orthopedic Surgery

Hemolysis is associated with acute kidney injury during major aortic surgery

Storage-Induced Damage to Red Blood Cell Mechanical Properties Can Be Only Partially Reversed by Rejuvenation

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