1997
DOI: 10.1002/(sici)1099-1557(199707)6:4<235::aid-pds293>3.3.co;2-v
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A comparison of fluvoxamine, fluoxetine, sertraline and paroxetine examined by observational cohort studies

Abstract: SUMMARYObjective Ð To compare the safety and side-eect pro®les of the four selective serotonin reuptake inhibitor antidepressants (SSRIs),¯uvoxamine,¯uoxetine, sertraline and paroxetine.Methods Ð The results from four observational cohort studies of the four SSRIs were compared. Each of these studies was conducted by Prescription-Event Monitoring (PEM). The exposure data were derived from general practitioner (GP) prescriptions con®dentially supplied by the Prescription Pricing Authority (PPA) in England. Outc… Show more

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Cited by 18 publications
(25 citation statements)
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“…[19][20][21][22] We excluded 18 studies because the comparison group was not individuals who had not ben exposed to antidepressant treatment. 21,[23][24][25][26][27][28][29][30][31][32][33][34][35][36][37][38][39] Two additional studies were excluded because a diagnosis of major depression or a proxy measure to identify patients suffering from depression was not used, 40 Group; study…”
Section: Resultsmentioning
confidence: 99%
“…[19][20][21][22] We excluded 18 studies because the comparison group was not individuals who had not ben exposed to antidepressant treatment. 21,[23][24][25][26][27][28][29][30][31][32][33][34][35][36][37][38][39] Two additional studies were excluded because a diagnosis of major depression or a proxy measure to identify patients suffering from depression was not used, 40 Group; study…”
Section: Resultsmentioning
confidence: 99%
“…When pre-existing risk factors are considered, the risk of suicide is comparable between¯uoxetine and many other commonly prescribed antidepressants, such as dothiepin, amitriptyiline, clomipramine, imipramine,¯upenthixol, lofepramine, mianserin, doxepin and trazodone (59). In an observational cohort study on the four SSRIs¯uoxetine (®nal cohort 12692),¯uvoxamine (®nal cohort 10983), sertraline (®nal cohort 12734) and paroxetine (®nal cohort 13741), there was no statistical difference between the four drugs in the number of suicides (60). The overall rate of suicide in patients taking SSRIs is similar to that in patients taking TCAs (61).…”
Section: Selective Serotonin Reuptake Inhibitors and Suicidementioning
confidence: 96%
“…Overall, more events were recorded during treatment with fluvoxamine than the other three SSRIs (Edwards et al, 1997;Mackay et al, 1997Mackay et al, , 1999. A PEM study of citalopram had not been carried out when these comparisons were published.…”
Section: Prescription Event Monitoringmentioning
confidence: 99%
“…For instance, it was reported that sexual dysfunction occurred more frequently during treatment with sertraline than fluvoxamine (Nemeroff et al, 1995), while one PEM publication suggested that impotence and ejaculatory failure occurred more often during treatment with paroxetine than fluoxetine, fluvoxamine and sertraline (Mackay et al, 1997). A prospective descriptive study of 344 male and female out-patients found that paroxetine was associated with significantly more impotence and delayed orgasm than fluoxetine, fluvoxamine and sertraline.…”
Section: Sexual Dysfunctionmentioning
confidence: 99%
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